U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lymphoma, Extranodal NK-T-Cell

MedGen UID:
364981
•Concept ID:
C1955906
•
Neoplastic Process
Synonyms: Extranodal NK T Cell Lymphoma; Extranodal NK-T-Cell Lymphoma; Extranodal NK-T-Cell Lymphomas; Lymphoma, Extranodal NK T Cell; Lymphomas, Extranodal NK-T-Cell; NK-T-Cell Lymphoma, Extranodal; NK-T-Cell Lymphomas, Extranodal

Definition

An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoma, Extranodal NK-T-Cell

Professional guidelines

PubMed

Diagnosis and management of rare paediatric Non-Hodgkin lymphoma.
Xavier AC, Suzuki R, Attarbaschi A
Best Pract Res Clin Haematol 2023 Mar;36(1):101440. Epub 2023 Jan 15 doi: 10.1016/j.beha.2023.101440. PMID: 36907633
Treatment of extranodal NK/T-cell lymphoma: From past to future.
Yan Z, Yao S, Wang Z, Zhou W, Yao Z, Liu Y
Front Immunol 2023;14:1088685. Epub 2023 Feb 7 doi: 10.3389/fimmu.2023.1088685. PMID: 36825002Free PMC Article
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Recent clinical studies

Etiology

Treatment of extranodal NK/T-cell lymphoma: From past to future.
Yan Z, Yao S, Wang Z, Zhou W, Yao Z, Liu Y
Front Immunol 2023;14:1088685. Epub 2023 Feb 7 doi: 10.3389/fimmu.2023.1088685. PMID: 36825002Free PMC Article
Extranodal T- and NK-cell lymphomas.
de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765Free PMC Article
EBV-associated NK and T-cell lymphoid neoplasms.
Kimura H, de Leval L, Cai Q, Kim WS
Curr Opin Oncol 2022 Sep 1;34(5):422-431. Epub 2022 Jul 27 doi: 10.1097/CCO.0000000000000889. PMID: 35900729Free PMC Article
Efficacy and Safety of a Pegasparaginase-Based Chemotherapy Regimen vs an L-asparaginase-Based Chemotherapy Regimen for Newly Diagnosed Advanced Extranodal Natural Killer/T-Cell Lymphoma: A Randomized Clinical Trial.
Wang X, Zhang L, Liu X, Li X, Li L, Fu X, Sun Z, Wu J, Zhang X, Yan J, Chang Y, Nan F, Zhou Z, Wu X, Tian L, Ma M, Li Z, Yu H, Zhu L, Wang Y, Shi C, Feng X, Li J, Ding M, Zhang J, Dong M, Xue H, Wang J, Zou L, Su L, Wu J, Liu L, Bao H, Zhang L, Guo Y, Guo S, Lu Y, Young KH, Li W, Zhang M
JAMA Oncol 2022 Jul 1;8(7):1035-1041. doi: 10.1001/jamaoncol.2022.1968. PMID: 35708709Free PMC Article
Modern Radiation Therapy for Extranodal Nasal-Type NK/T-cell Lymphoma: Risk-Adapted Therapy, Target Volume, and Dose Guidelines from the International Lymphoma Radiation Oncology Group.
Qi SN, Li YX, Specht L, Oguchi M, Tsang R, Ng A, Suh CO, Ricardi U, Mac Manus M, Dabaja B, Yahalom J
Int J Radiat Oncol Biol Phys 2021 Jul 15;110(4):1064-1081. Epub 2021 Feb 11 doi: 10.1016/j.ijrobp.2021.02.011. PMID: 33581262

Diagnosis

Extranodal T- and NK-cell lymphomas.
de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765Free PMC Article
Review on natural killer/T-cell lymphoma.
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Extranodal NK/T cell lymphoma, nasal type: An updated overview.
Sánchez-Romero C, Bologna-Molina R, Paes de Almeida O, Santos-Silva AR, Prado-Ribeiro AC, Brandão TB, Carlos R
Crit Rev Oncol Hematol 2021 Mar;159:103237. Epub 2021 Jan 22 doi: 10.1016/j.critrevonc.2021.103237. PMID: 33493634

Therapy

How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Modified SMILE (mSMILE) and intensity-modulated radiotherapy (IMRT) for extranodal NK-T lymphoma nasal type in a single-center population.
Ghione P, Qi S, Imber BS, Seshan V, Moskowitz A, Galasso N, Lunning M, Straus D, Sauter C, Dahi P, Dogan A, Yahalom J, Horwitz S
Leuk Lymphoma 2020 Dec;61(14):3331-3341. Epub 2020 Aug 26 doi: 10.1080/10428194.2020.1811864. PMID: 32844695Free PMC Article
NK/T-cell lymphomas.
Tse E, Kwong YL
Best Pract Res Clin Haematol 2019 Sep;32(3):253-261. Epub 2019 Jun 12 doi: 10.1016/j.beha.2019.06.005. PMID: 31585625

Prognosis

Treatment of extranodal NK/T-cell lymphoma: From past to future.
Yan Z, Yao S, Wang Z, Zhou W, Yao Z, Liu Y
Front Immunol 2023;14:1088685. Epub 2023 Feb 7 doi: 10.3389/fimmu.2023.1088685. PMID: 36825002Free PMC Article
Review on natural killer/T-cell lymphoma.
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Extranodal NK/T cell lymphoma, nasal type: An updated overview.
Sánchez-Romero C, Bologna-Molina R, Paes de Almeida O, Santos-Silva AR, Prado-Ribeiro AC, Brandão TB, Carlos R
Crit Rev Oncol Hematol 2021 Mar;159:103237. Epub 2021 Jan 22 doi: 10.1016/j.critrevonc.2021.103237. PMID: 33493634

Clinical prediction guides

How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
What we should know about natural killer/T-cell lymphomas.
Xiong J, Zhao W
Hematol Oncol 2019 Jun;37 Suppl 1:75-81. doi: 10.1002/hon.2588. PMID: 31187536
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

Recent systematic reviews

Allogeneic Hematopoietic Stem Cell Transplantation in Extranodal Natural Killer/T-cell Lymphoma.
Peng YY, Xiong YY, Zhang LX, Wang J, Zhang HB, Xiao Q, Guo SL
Turk J Haematol 2021 Jun 1;38(2):126-137. Epub 2021 Feb 4 doi: 10.4274/tjh.galenos.2021.2020.0438. PMID: 33535731Free PMC Article
Defining the toxicity of current regimens for extranodal NK/T cell lymphoma: a systematic review and metaproportion.
Pokrovsky VS, Vinnikov D
Expert Rev Anticancer Ther 2019 Jan;19(1):93-104. Epub 2018 Nov 23 doi: 10.1080/14737140.2019.1549992. PMID: 30449214
Treatment of localized extranodal NK/T cell lymphoma, nasal type: a systematic review.
Kim SJ, Yoon SE, Kim WS
J Hematol Oncol 2018 Dec 20;11(1):140. doi: 10.1186/s13045-018-0687-0. PMID: 30567593Free PMC Article
The optimal timing of radiotherapy in the combined modality therapy for limited-stage extranodal NK/T cell lymphoma (ENKTL): a systematic review and meta-analysis.
Hu S, Zhou D, Zhang W
Ann Hematol 2018 Dec;97(12):2279-2287. Epub 2018 Aug 20 doi: 10.1007/s00277-018-3479-2. PMID: 30128904
L-Asparaginase for newly diagnosed extra-nodal NK/T-cell lymphoma: systematic review and meta-analysis.
Pokrovsky VS, Vinnikov D
Expert Rev Anticancer Ther 2017 Aug;17(8):759-768. Epub 2017 Jun 21 doi: 10.1080/14737140.2017.1344100. PMID: 28621166

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...