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False Positive Result

MedGen UID:
361422
•Concept ID:
C1880724
•
Finding

Definition

Problem associated with the device incorrectly reporting that something has been detected and may mislead the operator to take certain actions. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFalse Positive Result

Professional guidelines

PubMed

Newborn Hearing Screening: Early Ear Examination Improves the Pass Rate.
Schwarz Y, Mauthner R, Kraus O, Gluk O, Globus O, Kariv L, Tamir SO
J Int Adv Otol 2023 Oct;19(5):402-406. doi: 10.5152/iao.2023.22987. PMID: 37789627Free PMC Article
Psychosocial consequences of receiving false-positive colorectal cancer screening results: a qualitative study.
Toft EL, Kaae SE, Malmqvist J, Brodersen J
Scand J Prim Health Care 2019 Jun;37(2):145-154. Epub 2019 May 11 doi: 10.1080/02813432.2019.1608040. PMID: 31079520Free PMC Article
Screening for postnatal depression in primary care: cost effectiveness analysis.
Paulden M, Palmer S, Hewitt C, Gilbody S
BMJ 2009 Dec 22;339:b5203. doi: 10.1136/bmj.b5203. PMID: 20028779Free PMC Article

Recent clinical studies

Etiology

Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.
Schrag D, Beer TM, McDonnell CH 3rd, Nadauld L, Dilaveri CA, Reid R, Marinac CR, Chung KC, Lopatin M, Fung ET, Klein EA
Lancet 2023 Oct 7;402(10409):1251-1260. doi: 10.1016/S0140-6736(23)01700-2. PMID: 37805216Free PMC Article
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.
Glechner A, Wagner G, Mitus JW, Teufer B, Klerings I, Böck N, Grillich L, Berzaczy D, Helbich TH, Gartlehner G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD009632. doi: 10.1002/14651858.CD009632.pub3. PMID: 36999589Free PMC Article
Evaluating Expanded Noninvasive Prenatal Screening.
Bayefsky MJ, Caplan AL, Hoskins IA
Obstet Gynecol 2022 Jun 1;139(6):1009-1011. Epub 2022 May 2 doi: 10.1097/AOG.0000000000004809. PMID: 35675597
Pneumocystis jirovecii Disease: Basis for the Revised EORTC/MSGERC Invasive Fungal Disease Definitions in Individuals Without Human Immunodeficiency Virus.
Lagrou K, Chen S, Masur H, Viscoli C, Decker CF, Pagano L, Groll AH
Clin Infect Dis 2021 Mar 12;72(Suppl 2):S114-S120. doi: 10.1093/cid/ciaa1805. PMID: 33709126Free PMC Article
How to prevent overdiagnosis.
Chiolero A, Paccaud F, Aujesky D, Santschi V, Rodondi N
Swiss Med Wkly 2015;145:w14060. Epub 2015 Jan 22 doi: 10.4414/smw.2015.14060. PMID: 25612105

Diagnosis

False-positive incidental lesions detected on contrast-enhanced breast MRI: clinical and imaging features.
Alikhassi A, Li X, Au F, Kulkarni S, Ghai S, Allison G, Freitas V
Breast Cancer Res Treat 2023 Apr;198(2):321-334. Epub 2023 Feb 6 doi: 10.1007/s10549-023-06861-y. PMID: 36740611
Evaluating Expanded Noninvasive Prenatal Screening.
Bayefsky MJ, Caplan AL, Hoskins IA
Obstet Gynecol 2022 Jun 1;139(6):1009-1011. Epub 2022 May 2 doi: 10.1097/AOG.0000000000004809. PMID: 35675597
How to prevent overdiagnosis.
Chiolero A, Paccaud F, Aujesky D, Santschi V, Rodondi N
Swiss Med Wkly 2015;145:w14060. Epub 2015 Jan 22 doi: 10.4414/smw.2015.14060. PMID: 25612105
Penetrating cardiac injuries.
Aksöyek A, Tütün U, Babaroğlu S, Parlar AI, Ulus AT, Katircioğlu SF
Ulus Travma Acil Cerrahi Derg 2007 Apr;13(2):135-41. PMID: 17682956
Exercise echocardiography.
Ryan T, Feigenbaum H
Am J Cardiol 1992 Jun 18;69(20):82H-89H. doi: 10.1016/0002-9149(92)90650-n. PMID: 1605124

Therapy

Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.
Schrag D, Beer TM, McDonnell CH 3rd, Nadauld L, Dilaveri CA, Reid R, Marinac CR, Chung KC, Lopatin M, Fung ET, Klein EA
Lancet 2023 Oct 7;402(10409):1251-1260. doi: 10.1016/S0140-6736(23)01700-2. PMID: 37805216Free PMC Article
Novel biomarkers for drug-induced liver injury.
Humphries C, Dear JW
Clin Toxicol (Phila) 2023 Aug;61(8):567-572. Epub 2023 Oct 10 doi: 10.1080/15563650.2023.2259089. PMID: 37767912
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.
Glechner A, Wagner G, Mitus JW, Teufer B, Klerings I, Böck N, Grillich L, Berzaczy D, Helbich TH, Gartlehner G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD009632. doi: 10.1002/14651858.CD009632.pub3. PMID: 36999589Free PMC Article
How to prevent overdiagnosis.
Chiolero A, Paccaud F, Aujesky D, Santschi V, Rodondi N
Swiss Med Wkly 2015;145:w14060. Epub 2015 Jan 22 doi: 10.4414/smw.2015.14060. PMID: 25612105
Ectopic pregnancy.
Cowan BD
Curr Opin Obstet Gynecol 1993 Jun;5(3):328-32. PMID: 8329648

Prognosis

Breast Cancer Incidence After a False-Positive Mammography Result.
Mao X, He W, Humphreys K, Eriksson M, Holowko N, Yang H, Tapia J, Hall P, Czene K
JAMA Oncol 2024 Jan 1;10(1):63-70. doi: 10.1001/jamaoncol.2023.4519. PMID: 37917078Free PMC Article
Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.
Schrag D, Beer TM, McDonnell CH 3rd, Nadauld L, Dilaveri CA, Reid R, Marinac CR, Chung KC, Lopatin M, Fung ET, Klein EA
Lancet 2023 Oct 7;402(10409):1251-1260. doi: 10.1016/S0140-6736(23)01700-2. PMID: 37805216Free PMC Article
Novel biomarkers for drug-induced liver injury.
Humphries C, Dear JW
Clin Toxicol (Phila) 2023 Aug;61(8):567-572. Epub 2023 Oct 10 doi: 10.1080/15563650.2023.2259089. PMID: 37767912
Evaluating Expanded Noninvasive Prenatal Screening.
Bayefsky MJ, Caplan AL, Hoskins IA
Obstet Gynecol 2022 Jun 1;139(6):1009-1011. Epub 2022 May 2 doi: 10.1097/AOG.0000000000004809. PMID: 35675597
False-positive interferences of common urine drug screen immunoassays: a review.
Saitman A, Park HD, Fitzgerald RL
J Anal Toxicol 2014 Sep;38(7):387-96. Epub 2014 Jul 1 doi: 10.1093/jat/bku075. PMID: 24986836

Clinical prediction guides

Breast Cancer Incidence After a False-Positive Mammography Result.
Mao X, He W, Humphreys K, Eriksson M, Holowko N, Yang H, Tapia J, Hall P, Czene K
JAMA Oncol 2024 Jan 1;10(1):63-70. doi: 10.1001/jamaoncol.2023.4519. PMID: 37917078Free PMC Article
Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.
Schrag D, Beer TM, McDonnell CH 3rd, Nadauld L, Dilaveri CA, Reid R, Marinac CR, Chung KC, Lopatin M, Fung ET, Klein EA
Lancet 2023 Oct 7;402(10409):1251-1260. doi: 10.1016/S0140-6736(23)01700-2. PMID: 37805216Free PMC Article
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.
Glechner A, Wagner G, Mitus JW, Teufer B, Klerings I, Böck N, Grillich L, Berzaczy D, Helbich TH, Gartlehner G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD009632. doi: 10.1002/14651858.CD009632.pub3. PMID: 36999589Free PMC Article
Evaluating Expanded Noninvasive Prenatal Screening.
Bayefsky MJ, Caplan AL, Hoskins IA
Obstet Gynecol 2022 Jun 1;139(6):1009-1011. Epub 2022 May 2 doi: 10.1097/AOG.0000000000004809. PMID: 35675597
Exercise echocardiography.
Ryan T, Feigenbaum H
Am J Cardiol 1992 Jun 18;69(20):82H-89H. doi: 10.1016/0002-9149(92)90650-n. PMID: 1605124

Recent systematic reviews

Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.
Glechner A, Wagner G, Mitus JW, Teufer B, Klerings I, Böck N, Grillich L, Berzaczy D, Helbich TH, Gartlehner G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD009632. doi: 10.1002/14651858.CD009632.pub3. PMID: 36999589Free PMC Article
Effect and safety of mesenchymal stem cells for patients with COVID-19: Systematic review and meta-analysis with trial sequential analysis.
Zhang Z, Shao S, Liu X, Tong Z
J Med Virol 2023 Apr;95(4):e28702. doi: 10.1002/jmv.28702. PMID: 36964933
Systematic review on women's values and preferences concerning breast cancer screening and diagnostic services.
Mathioudakis AG, Salakari M, Pylkkanen L, Saz-Parkinson Z, Bramesfeld A, Deandrea S, Lerda D, Neamtiu L, Pardo-Hernandez H, Solà I, Alonso-Coello P
Psychooncology 2019 May;28(5):939-947. Epub 2019 Mar 24 doi: 10.1002/pon.5041. PMID: 30812068Free PMC Article
Psychological Burden Associated With Lung Cancer Screening: A Systematic Review.
Wu GX, Raz DJ, Brown L, Sun V
Clin Lung Cancer 2016 Sep;17(5):315-324. Epub 2016 Mar 30 doi: 10.1016/j.cllc.2016.03.007. PMID: 27130469Free PMC Article
A systematic review of stroke recognition instruments in hospital and prehospital settings.
Rudd M, Buck D, Ford GA, Price CI
Emerg Med J 2016 Nov;33(11):818-822. Epub 2015 Nov 16 doi: 10.1136/emermed-2015-205197. PMID: 26574548

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