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Multilocular Thymic Cyst

MedGen UID:
353946
•Concept ID:
C1709089
•
Finding

Definition

A multicystic lesion that arises from the epithelial component of the thymus gland. It is usually associated with the presence of lymphoid follicles and degenerative changes. Although its etiology is unknown, it has been described in patients with HIV infection and in patients with nodular sclerosis Hodgkin lymphoma affecting the thymus gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultilocular Thymic Cyst

Recent clinical studies

Therapy

Thoracic diseases associated with HIV infection in the era of antiretroviral therapy: clinical and imaging findings.
Chou SH, Prabhu SJ, Crothers K, Stern EJ, Godwin JD, Pipavath SN
Radiographics 2014 Jul-Aug;34(4):895-911. doi: 10.1148/rg.344130115. PMID: 25019430Free PMC Article
Regression of thymoma associated with a multilocular thymic cyst: report of a case.
Toyokawa G, Taguchi K, Ohba T, Hirai F, Yamaguchi M, Hamatake M, Seto T, Nishiyama K, Shida Y, Sugio K, Ichinose Y
Surg Today 2014 Mar;44(3):577-80. Epub 2012 Nov 25 doi: 10.1007/s00595-012-0436-x. PMID: 23184327
Multilocular thymic cysts: imaging features in children with human immunodeficiency virus infection.
Avila NA, Mueller BU, Carrasquillo JA, Kontny HU, Jaffe ES, Pizzo PA
Radiology 1996 Oct;201(1):130-4. doi: 10.1148/radiology.201.1.8816533. PMID: 8816533

Prognosis

Micronodular Thymoma With Lymphoid Stroma: A Trio of Cases, With Diverse-associated Histological Features.
Bakshi N, Dhawan S, Rao S, Singh Rawat K
Int J Surg Pathol 2021 Sep;29(6):693-697. Epub 2021 Mar 8 doi: 10.1177/10668969211001110. PMID: 33683925
Micronodular Thymomas With Prominent Cystic Changes: A Clinicopathological and Immunohistochemical Study of 25 Cases.
Oramas DM, Moran CA
Int J Surg Pathol 2021 Jun;29(4):352-357. Epub 2020 Oct 7 doi: 10.1177/1066896920963803. PMID: 33026263
Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases.
Shen X, Jin Y, Shen L, Sun Y, Chen H, Li Y
Diagn Pathol 2018 Jun 26;13(1):41. doi: 10.1186/s13000-018-0719-7. PMID: 29945642Free PMC Article
Micronodular thymoma with lymphoid stroma: Two cases, one in a multilocular thymic cyst, and literature review.
Qu L, Xiong Y, Yao Q, Zhang B, Li T
Thorac Cancer 2017 Nov;8(6):734-740. Epub 2017 Sep 20 doi: 10.1111/1759-7714.12517. PMID: 28941195Free PMC Article
Multilocular thymic cyst associated with thymoma: a clinicopathologic study of 20 cases with an emphasis on the pathogenesis of cyst formation.
Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Mizuno T, Ishiguro F, Yokoi K
Am J Surg Pathol 2012 Dec;36(12):1857-64. doi: 10.1097/PAS.0b013e31826320c4. PMID: 23026930

Clinical prediction guides

A case of a shrunken multilocular mediastinal cyst that developed into thymic carcinoma with lung metastases 13 years later.
Sugai K, Nakaoka K, Tobita R, Kikuchi S, Inoue K, Enokido M, Kiyoshima M
Thorac Cancer 2024 Jan;15(1):94-97. Epub 2023 Nov 28 doi: 10.1111/1759-7714.15174. PMID: 38018322Free PMC Article
Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4-related disease.
Oda R, Okuda K, Murase T, Watanabe T, Sakane T, Tatematsu T, Yokota K, Haneda H, Nakanishi R
Thorac Cancer 2019 Jan;10(1):116-119. Epub 2018 Nov 23 doi: 10.1111/1759-7714.12914. PMID: 30467988Free PMC Article
Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases.
Shen X, Jin Y, Shen L, Sun Y, Chen H, Li Y
Diagn Pathol 2018 Jun 26;13(1):41. doi: 10.1186/s13000-018-0719-7. PMID: 29945642Free PMC Article
Multilocular thymic cyst associated with thymoma: a clinicopathologic study of 20 cases with an emphasis on the pathogenesis of cyst formation.
Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Mizuno T, Ishiguro F, Yokoi K
Am J Surg Pathol 2012 Dec;36(12):1857-64. doi: 10.1097/PAS.0b013e31826320c4. PMID: 23026930
Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases.
Weissferdt A, Moran CA
Am J Surg Pathol 2011 Jul;35(7):1074-9. doi: 10.1097/PAS.0b013e31821c7402. PMID: 21677542

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