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Familial focal alopecia(ALPF)

MedGen UID:
350835
•Concept ID:
C1863092
•
Disease or Syndrome
Synonym: Alopecia, Familial Focal
 
Monarch Initiative: MONDO:0007084
OMIM®: 104110

Clinical features

From HPO
Patchy alopecia
MedGen UID:
350774
•Concept ID:
C1862862
•
Finding
Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options.
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Childhood Alopecia Areata: An Overview of Treatment and Recent Patents.
Hon KL, Luk DCK, Leung AKC, Ng C, Loo SKF
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):117-132. doi: 10.2174/1872213X14999200728145822. PMID: 32723274
PUVA treatment for alopecia areata.
Lassus A, Kianto U, Johansson E, Juvakoski T
Dermatologica 1980;161(5):298-304. doi: 10.1159/000250381. PMID: 7439478

Recent clinical studies

Etiology

Focal Dermal Hypoplasia with Osteopathia Striata.
Almashaqbeh SS, Aljammal DS, Alharahsheh HM, Alqudah SF, Alkrimeen RA
Med Arch 2022 Aug;76(4):301-304. doi: 10.5455/medarh.2022.76.301-304. PMID: 36313953Free PMC Article
Cutaneous Cryosurgery for Common Skin Conditions.
Clebak KT, Mendez-Miller M, Croad J
Am Fam Physician 2020 Apr 1;101(7):399-406. PMID: 32227823
Variant PADI3 in Central Centrifugal Cicatricial Alopecia.
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E
N Engl J Med 2019 Feb 28;380(9):833-841. Epub 2019 Feb 13 doi: 10.1056/NEJMoa1816614. PMID: 30763140
ORAL-FACIAL-DIGITAL SYNDROME TYPE I (CLINICAL CASE).
Horlenko O, Lenchenko A, Kossey G, Tomey A, Debretseni O
Georgian Med News 2018 Dec;(285):47-51. PMID: 30702069
Alopecia areata and auto-immunity.
Friedmann PS
Br J Dermatol 1981 Aug;105(2):153-7. doi: 10.1111/j.1365-2133.1981.tb01200.x. PMID: 7284245

Diagnosis

Erythroderma with total scarring alopecia.
Karrakchou B, Fliti A, Meziane M, Senouci K
BMJ Case Rep 2023 Jan 31;16(1) doi: 10.1136/bcr-2022-250782. PMID: 36720517Free PMC Article
Focal Dermal Hypoplasia with Osteopathia Striata.
Almashaqbeh SS, Aljammal DS, Alharahsheh HM, Alqudah SF, Alkrimeen RA
Med Arch 2022 Aug;76(4):301-304. doi: 10.5455/medarh.2022.76.301-304. PMID: 36313953Free PMC Article
Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options.
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Incontinentia pigmenti (Bloch-Sulzberger syndrome).
Narayanan MJ, Rangasamy S, Narayanan V
Handb Clin Neurol 2015;132:271-80. doi: 10.1016/B978-0-444-62702-5.00020-2. PMID: 26564087
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Therapy

First-in-Human, Phase I Dose-Escalation and Dose-Expansion Study of Trophoblast Cell-Surface Antigen 2-Directed Antibody-Drug Conjugate Datopotamab Deruxtecan in Non-Small-Cell Lung Cancer: TROPION-PanTumor01.
Shimizu T, Sands J, Yoh K, Spira A, Garon EB, Kitazono S, Johnson ML, Meric-Bernstam F, Tolcher AW, Yamamoto N, Greenberg J, Kawasaki Y, Zebger-Gong H, Kobayashi F, Phillips P, Lisberg AE, Heist RS
J Clin Oncol 2023 Oct 10;41(29):4678-4687. Epub 2023 Jun 16 doi: 10.1200/JCO.23.00059. PMID: 37327461Free PMC Article
Enfortumab Vedotin Plus Pembrolizumab in Previously Untreated Advanced Urothelial Cancer.
Hoimes CJ, Flaig TW, Milowsky MI, Friedlander TW, Bilen MA, Gupta S, Srinivas S, Merchan JR, McKay RR, Petrylak DP, Sasse C, Moreno BH, Yu Y, Carret AS, Rosenberg JE
J Clin Oncol 2023 Jan 1;41(1):22-31. Epub 2022 Aug 30 doi: 10.1200/JCO.22.01643. PMID: 36041086Free PMC Article
Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options.
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Targeting the Janus Kinase Family in Autoimmune Skin Diseases.
Howell MD, Kuo FI, Smith PA
Front Immunol 2019;10:2342. Epub 2019 Oct 9 doi: 10.3389/fimmu.2019.02342. PMID: 31649667Free PMC Article
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Prognosis

Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options.
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Childhood Alopecia Areata: An Overview of Treatment and Recent Patents.
Hon KL, Luk DCK, Leung AKC, Ng C, Loo SKF
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):117-132. doi: 10.2174/1872213X14999200728145822. PMID: 32723274
Variant PADI3 in Central Centrifugal Cicatricial Alopecia.
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E
N Engl J Med 2019 Feb 28;380(9):833-841. Epub 2019 Feb 13 doi: 10.1056/NEJMoa1816614. PMID: 30763140
An Excellent Response to Tofacitinib in a Pediatric Alopecia Patient: A Case Report and Review.
Brown L, Skopit S
J Drugs Dermatol 2018 Aug 1;17(8):914-917. PMID: 30124734
Childhood vitiligo: clinicoepidemiologic profile of 268 children from the Kumaun region of Uttarakhand, India.
Agarwal S, Gupta S, Ojha A, Sinha R
Pediatr Dermatol 2013 May-Jun;30(3):348-53. Epub 2012 Dec 26 doi: 10.1111/pde.12032. PMID: 23278409

Clinical prediction guides

Expanding the phenotypic spectrum and clinical severity associated with WLS gene.
Abdel-Salam GMH, Afifi HH, Abdel-Hamid MS, Ahmed NEB, Taher MB, El-Kamah G, Thiele H, Nürnberg PN, Bolz HJ
J Hum Genet 2023 Sep;68(9):607-613. Epub 2023 Apr 28 doi: 10.1038/s10038-023-01152-2. PMID: 37106064
The level of stress and the assessment of selected clinical parameters in patients with androgenetic alopecia.
Kozicka K, Łukasik A, Jaworek A, Pastuszczak M, Spałkowska M, Kłosowicz A, Dyduch G, Wojas-Pelc A
Pol Merkur Lekarski 2020 Dec 22;48(288):427-430. PMID: 33387431
Variant PADI3 in Central Centrifugal Cicatricial Alopecia.
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E
N Engl J Med 2019 Feb 28;380(9):833-841. Epub 2019 Feb 13 doi: 10.1056/NEJMoa1816614. PMID: 30763140
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984
Clinical profile and impact on quality of life: seven years experience with patients of alopecia areata.
Al-Mutairi N, Eldin ON
Indian J Dermatol Venereol Leprol 2011 Jul-Aug;77(4):489-93. doi: 10.4103/0378-6323.82411. PMID: 21727697

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