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Tune deafness

MedGen UID:
349862
Concept ID:
C1860646
Disease or Syndrome
Synonyms: AMUSIA, CONGENITAL; DYSMELODIA; TONE DEAFNESS
 
Monarch Initiative: MONDO:0008615
OMIM®: 191200

Definition

Tune deafness, or congenital amusia, is a lifelong deficient in music perception that cannot be explained by hearing loss, brain damage, intellectual deficiencies, or lack of exposure. The disorder affects predominantly the melodic pitch dimension (summary by Peretz et al., 2009). See 159300 for an opposite situation, that of musical perfect pitch. [from OMIM]

Clinical features

From HPO
Hearing impairment
MedGen UID:
235586
Concept ID:
C1384666
Disease or Syndrome
A decreased magnitude of the sensory perception of sound.

Recent clinical studies

Etiology

Sihvonen AJ, Ferguson MA, Chen V, Soinila S, Särkämö T, Joutsa J
J Neurosci 2024 Apr 10;44(15) doi: 10.1523/JNEUROSCI.1922-23.2024. PMID: 38423761Free PMC Article
Zhu J, Chen X, Chen F, Zhang C, Shao J, Wiener S
J Acoust Soc Am 2023 May 1;153(5):3117. doi: 10.1121/10.0019472. PMID: 37232583
Tao W, Huang H, Haponenko H, Sun HJ
PLoS One 2019;14(12):e0225519. Epub 2019 Dec 2 doi: 10.1371/journal.pone.0225519. PMID: 31790454Free PMC Article
Vuvan DT, Paquette S, Mignault Goulet G, Royal I, Felezeu M, Peretz I
Behav Res Methods 2018 Apr;50(2):662-672. doi: 10.3758/s13428-017-0892-8. PMID: 28455794
Williamson VJ, Stewart L
Handb Clin Neurol 2013;111:237-9. doi: 10.1016/B978-0-444-52891-9.00024-5. PMID: 23622169

Diagnosis

Tao W, Huang H, Haponenko H, Sun HJ
PLoS One 2019;14(12):e0225519. Epub 2019 Dec 2 doi: 10.1371/journal.pone.0225519. PMID: 31790454Free PMC Article
Kawamura M, Miller MW
Front Neurol Neurosci 2019;44:83-88. Epub 2019 Apr 30 doi: 10.1159/000494955. PMID: 31220839
Couvignou M, Peretz I, Ramus F
Cogn Neuropsychol 2019 Feb-Mar;36(1-2):1-17. Epub 2019 Feb 20 doi: 10.1080/02643294.2019.1578205. PMID: 30785364
Vuvan DT, Paquette S, Mignault Goulet G, Royal I, Felezeu M, Peretz I
Behav Res Methods 2018 Apr;50(2):662-672. doi: 10.3758/s13428-017-0892-8. PMID: 28455794
Peretz I, Vuvan DT
Eur J Hum Genet 2017 May;25(5):625-630. Epub 2017 Feb 22 doi: 10.1038/ejhg.2017.15. PMID: 28224991Free PMC Article

Therapy

Vuvan DT, Zendel BR, Peretz I
Sci Rep 2018 May 8;8(1):7283. doi: 10.1038/s41598-018-25518-1. PMID: 29740029Free PMC Article
Tang W, Wang XJ, Li JQ, Liu C, Dong Q, Nan Y
Hear Res 2018 Jun;363:62-69. Epub 2018 Mar 6 doi: 10.1016/j.heares.2018.03.004. PMID: 29534831
Lu X, Sun Y, Ho HT, Thompson WF
PLoS One 2017;12(6):e0179252. Epub 2017 Jun 15 doi: 10.1371/journal.pone.0179252. PMID: 28617864Free PMC Article
Jones JL, Lucker J, Zalewski C, Brewer C, Drayna D
J Commun Disord 2009 May-Jun;42(3):226-34. Epub 2009 Jan 19 doi: 10.1016/j.jcomdis.2009.01.001. PMID: 19233383Free PMC Article
Jones JL, Zalewski C, Brewer C, Lucker J, Drayna D
Ear Hear 2009 Feb;30(1):63-72. doi: 10.1097/AUD.0b013e31818ff95e. PMID: 19125028Free PMC Article

Prognosis

Peretz I, Ross J, Bourassa CV, Perreault LL, Dion PA, Weiss MW, Felezeu M, Rouleau GA, Dubé MP
Ann N Y Acad Sci 2022 Nov;1517(1):279-285. Epub 2022 Aug 18 doi: 10.1111/nyas.14883. PMID: 35980667
Samiee S, Vuvan D, Florin E, Albouy P, Peretz I, Baillet S
J Neurosci 2022 May 4;42(18):3823-3835. Epub 2022 Mar 29 doi: 10.1523/JNEUROSCI.0630-21.2022. PMID: 35351829Free PMC Article
Sun Y, Lu X, Ho HT, Thompson WF
Sci Rep 2017 Mar 13;7:44285. doi: 10.1038/srep44285. PMID: 28287166Free PMC Article
Hutchins S, Peretz I
Brain Lang 2013 Apr;125(1):106-17. Epub 2013 Mar 5 doi: 10.1016/j.bandl.2013.01.011. PMID: 23467261
Thompson WF, Marin MM, Stewart L
Proc Natl Acad Sci U S A 2012 Nov 13;109(46):19027-32. Epub 2012 Oct 29 doi: 10.1073/pnas.1210344109. PMID: 23112175Free PMC Article

Clinical prediction guides

Graves JE, Pralus A, Fornoni L, Oxenham AJ, Tillmann B, Caclin A
J Cogn Neurosci 2023 May 1;35(5):765-780. doi: 10.1162/jocn_a_01973. PMID: 36802367Free PMC Article
Tao W, Huang H, Haponenko H, Sun HJ
PLoS One 2019;14(12):e0225519. Epub 2019 Dec 2 doi: 10.1371/journal.pone.0225519. PMID: 31790454Free PMC Article
Albouy P, Lévêque Y, Hyde KL, Bouchet P, Tillmann B, Caclin A
Neuropsychologia 2015 Jan;67:111-20. Epub 2014 Dec 11 doi: 10.1016/j.neuropsychologia.2014.12.006. PMID: 25499145
Albouy P, Schulze K, Caclin A, Tillmann B
Brain Res 2013 Nov 6;1537:224-32. Epub 2013 Sep 13 doi: 10.1016/j.brainres.2013.09.003. PMID: 24041778
Hutchins S, Peretz I
Brain Lang 2013 Apr;125(1):106-17. Epub 2013 Mar 5 doi: 10.1016/j.bandl.2013.01.011. PMID: 23467261

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