U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Enlargement of the distal femoral epiphysis

MedGen UID:
334682
•Concept ID:
C1843105
•
Finding
Synonym: Large distal femoral epiphyses
 
HPO: HP:0006438

Definition

An abnormal enlargement of the distal epiphysis of the femur. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnlargement of the distal femoral epiphysis

Conditions with this feature

Acrocapitofemoral dysplasia
MedGen UID:
334681
•Concept ID:
C1843096
•
Disease or Syndrome
Acrocapitofemoral dysplasia (ACFD) is an autosomal recessive skeletal dysplasia characterized by postnatal-onset disproportionate short stature, relatively large head, narrow thorax, lumbar lordosis, short limbs, and brachydactyly with small broad nails (Ozyavuz Cubuk and Duz, 2021).
See: Condition Record
Acrocapitofemoral dysplasia

Recent clinical studies

Etiology

Postoperative radiographic observations following transphyseal anterior cruciate ligament reconstruction in skeletally immature patients.
Smoak JB, Macfarlane A, Kluczynski MA, Ferrick MR, Doak JP, Bisson LJ, Marzo JM
Skeletal Radiol 2020 Jun;49(6):861-868. Epub 2019 Dec 17 doi: 10.1007/s00256-019-03361-3. PMID: 31848655
Growth plate abnormalities in pediatric cancer patients undergoing phase 1 anti-angiogenic therapy: a report from the Children's Oncology Group Phase I Consortium.
Voss SD, Glade-Bender J, Spunt SL, DuBois SG, Widemann BC, Park JR, Leary SE, Nelson MD, Adamson PC, Blaney SM, Weigel B
Pediatr Blood Cancer 2015 Jan;62(1):45-51. Epub 2014 Sep 24 doi: 10.1002/pbc.25229. PMID: 25257751Free PMC Article
The influence of relative body breadth on the diaphyseal morphology of the human lower limb.
Davies TG, Stock JT
Am J Hum Biol 2014 Nov-Dec;26(6):822-35. Epub 2014 Aug 28 doi: 10.1002/ajhb.22606. PMID: 25163696
MRI evaluation of the knee in children with infantile Blount disease: tibial and extra-tibial findings.
Ho-Fung V, Jaimes C, Delgado J, Davidson RS, Jaramillo D
Pediatr Radiol 2013 Oct;43(10):1316-26. Epub 2013 Apr 25 doi: 10.1007/s00247-013-2686-1. PMID: 23615630
Epiphyseal ossification centers in the assessment of fetal maturity: sonographic correlation with the amniocentesis lung profile.
Mahony BS, Bowie JD, Killam AP, Kay HH, Cooper C
Radiology 1986 May;159(2):521-4. doi: 10.1148/radiology.159.2.3515425. PMID: 3515425

Diagnosis

MRI evaluation of the knee in children with infantile Blount disease: tibial and extra-tibial findings.
Ho-Fung V, Jaimes C, Delgado J, Davidson RS, Jaramillo D
Pediatr Radiol 2013 Oct;43(10):1316-26. Epub 2013 Apr 25 doi: 10.1007/s00247-013-2686-1. PMID: 23615630
MRI findings in Dyggve-Melchior-Clausen syndrome, a rare spondyloepiphyseal dysplasia.
Carbonell PG, Fernández PD, Vicente-Franqueira JR
J Magn Reson Imaging 2005 Oct;22(4):572-6. doi: 10.1002/jmri.20414. PMID: 16161079
Desbuquois dysplasia, a reevaluation with abnormal and "normal" hands: radiographic manifestations.
Faivre L, Cormier-Daire V, Eliott AM, Field F, Munnich A, Maroteaux P, Le Merrer M, Lachman R
Am J Med Genet A 2004 Jan 1;124A(1):48-53. doi: 10.1002/ajmg.a.20440. PMID: 14679586
Metaphyseal chondrodysplasia, Schmid type. Clinical and radiographic delineation with a review of the literature.
Lachman RS, Rimoin DL, Spranger J
Pediatr Radiol 1988;18(2):93-102. doi: 10.1007/BF02387549. PMID: 3281118

Therapy

Growth plate abnormalities in pediatric cancer patients undergoing phase 1 anti-angiogenic therapy: a report from the Children's Oncology Group Phase I Consortium.
Voss SD, Glade-Bender J, Spunt SL, DuBois SG, Widemann BC, Park JR, Leary SE, Nelson MD, Adamson PC, Blaney SM, Weigel B
Pediatr Blood Cancer 2015 Jan;62(1):45-51. Epub 2014 Sep 24 doi: 10.1002/pbc.25229. PMID: 25257751Free PMC Article

Prognosis

Hypertrophy Associated With Vascular Malformations: Analysis of Growth and Results of Epiphysiodesis.
Borowski A, Bajelidze G, Bowen JR
Orthopedics 2018 Jul 1;41(4):e574-e579. Epub 2017 Dec 19 doi: 10.3928/01477447-20171213-07. PMID: 29257190
Rapidly growing giant cell tumor of bone in a skeletally immature girl.
Akaike G, Ueno T, Matsumoto S, Motoi N, Matsueda K
Skeletal Radiol 2016 Apr;45(4):567-73. Epub 2015 Nov 20 doi: 10.1007/s00256-015-2276-4. PMID: 26585568
Growth plate abnormalities in pediatric cancer patients undergoing phase 1 anti-angiogenic therapy: a report from the Children's Oncology Group Phase I Consortium.
Voss SD, Glade-Bender J, Spunt SL, DuBois SG, Widemann BC, Park JR, Leary SE, Nelson MD, Adamson PC, Blaney SM, Weigel B
Pediatr Blood Cancer 2015 Jan;62(1):45-51. Epub 2014 Sep 24 doi: 10.1002/pbc.25229. PMID: 25257751Free PMC Article
Biomechanical reasons for the divergent morphology of the knee joint and the distal epiphyseal suture in hominoids.
Preuschoft H, Tardieu C
Folia Primatol (Basel) 1996;66(1-4):82-92. doi: 10.1159/000157187. PMID: 8953752
Epiphyseal ossification centers in the assessment of fetal maturity: sonographic correlation with the amniocentesis lung profile.
Mahony BS, Bowie JD, Killam AP, Kay HH, Cooper C
Radiology 1986 May;159(2):521-4. doi: 10.1148/radiology.159.2.3515425. PMID: 3515425

Clinical prediction guides

Postoperative radiographic observations following transphyseal anterior cruciate ligament reconstruction in skeletally immature patients.
Smoak JB, Macfarlane A, Kluczynski MA, Ferrick MR, Doak JP, Bisson LJ, Marzo JM
Skeletal Radiol 2020 Jun;49(6):861-868. Epub 2019 Dec 17 doi: 10.1007/s00256-019-03361-3. PMID: 31848655
Hypertrophy Associated With Vascular Malformations: Analysis of Growth and Results of Epiphysiodesis.
Borowski A, Bajelidze G, Bowen JR
Orthopedics 2018 Jul 1;41(4):e574-e579. Epub 2017 Dec 19 doi: 10.3928/01477447-20171213-07. PMID: 29257190
The influence of relative body breadth on the diaphyseal morphology of the human lower limb.
Davies TG, Stock JT
Am J Hum Biol 2014 Nov-Dec;26(6):822-35. Epub 2014 Aug 28 doi: 10.1002/ajhb.22606. PMID: 25163696
Effects of estrogen on growth plate senescence and epiphyseal fusion.
Weise M, De-Levi S, Barnes KM, Gafni RI, Abad V, Baron J
Proc Natl Acad Sci U S A 2001 Jun 5;98(12):6871-6. Epub 2001 May 29 doi: 10.1073/pnas.121180498. PMID: 11381135Free PMC Article
Epiphyseal ossification centers in the assessment of fetal maturity: sonographic correlation with the amniocentesis lung profile.
Mahony BS, Bowie JD, Killam AP, Kay HH, Cooper C
Radiology 1986 May;159(2):521-4. doi: 10.1148/radiology.159.2.3515425. PMID: 3515425

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...