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Nasopharyngeal Basaloid Carcinoma

MedGen UID:
328304
•Concept ID:
C1711232
•
Neoplastic Process
Synonym: Nasopharyngeal Basaloid Squamous Cell Carcinoma

Definition

An aggressive variant of squamous cell carcinoma that arises from the nasopharynx. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Basaloid Carcinoma

Professional guidelines

PubMed

The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database.
Gootee J, Patel M, Aurit S, Silberstein P
Clin Transl Oncol 2020 Dec;22(12):2264-2274. Epub 2020 May 21 doi: 10.1007/s12094-020-02370-2. PMID: 32440914
Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article

Recent clinical studies

Etiology

Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study.
Ogun GO, Olusanya AA, Akinmoladun VI, Adeyemo AA, Ogunkeyede SA, Daniel A, Awosusi BL, Fatunla EO, Fasunla AJ, Onakoya PA, Adeosun AA, Nwaorgu OG
Pan Afr Med J 2020;36:82. Epub 2020 Jun 9 doi: 10.11604/pamj.2020.36.82.19657. PMID: 32774641Free PMC Article
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
Basaloid nasopharyngeal carcinoma: A population-based analysis of a rare tumor.
Unsal AA, Booth JR, Rossi NA, Byrd JK, Kountakis SE
Laryngoscope 2019 Dec;129(12):2727-2732. Epub 2019 Jan 10 doi: 10.1002/lary.27788. PMID: 30632158
Epstein-Barr virus association is rare in esophageal squamous cell carcinoma.
Yanai H, Hirano A, Matsusaki K, Kawano T, Miura O, Yoshida T, Okita K, Shimizu N
Int J Gastrointest Cancer 2003;33(2-3):165-70. doi: 10.1385/IJGC:33:2-3:165. PMID: 14716066
The basaloid squamous cell carcinoma of the nasopharynx.
Müller E, Beleites E
Rhinology 2000 Dec;38(4):208-11. PMID: 11190760

Diagnosis

Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study.
Ogun GO, Olusanya AA, Akinmoladun VI, Adeyemo AA, Ogunkeyede SA, Daniel A, Awosusi BL, Fatunla EO, Fasunla AJ, Onakoya PA, Adeosun AA, Nwaorgu OG
Pan Afr Med J 2020;36:82. Epub 2020 Jun 9 doi: 10.11604/pamj.2020.36.82.19657. PMID: 32774641Free PMC Article
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
Basaloid nasopharyngeal carcinoma: A population-based analysis of a rare tumor.
Unsal AA, Booth JR, Rossi NA, Byrd JK, Kountakis SE
Laryngoscope 2019 Dec;129(12):2727-2732. Epub 2019 Jan 10 doi: 10.1002/lary.27788. PMID: 30632158
Poorly differentiated sinonasal tract malignancies: A review focusing on recently described entities.
Agaimy A
Cesk Patol 2016;52(3):146-53. PMID: 27526015
The basaloid squamous cell carcinoma of the nasopharynx.
Müller E, Beleites E
Rhinology 2000 Dec;38(4):208-11. PMID: 11190760

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
Basaloid nasopharyngeal carcinoma: A population-based analysis of a rare tumor.
Unsal AA, Booth JR, Rossi NA, Byrd JK, Kountakis SE
Laryngoscope 2019 Dec;129(12):2727-2732. Epub 2019 Jan 10 doi: 10.1002/lary.27788. PMID: 30632158
Poorly differentiated sinonasal tract malignancies: A review focusing on recently described entities.
Agaimy A
Cesk Patol 2016;52(3):146-53. PMID: 27526015
The basaloid squamous cell carcinoma of the nasopharynx.
Müller E, Beleites E
Rhinology 2000 Dec;38(4):208-11. PMID: 11190760

Clinical prediction guides

The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients.
Pan XX, Liu YJ, Yang W, Chen YF, Tang WB, Li CR
Laryngoscope 2020 Mar;130(3):E83-E88. Epub 2019 Jun 12 doi: 10.1002/lary.28099. PMID: 31188486
Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article
Atypical squamous cell carcinoma of the larynx and hypopharynx: radiologic features and pathologic correlation.
Becker M, Moulin G, Kurt AM, Zbären P, Dulgerov P, Marchal F, Zanaret P, Lehmann W, Rüfenacht DA, Terrier F
Eur Radiol 1998;8(9):1541-51. doi: 10.1007/s003300050584. PMID: 9866759

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