From HPO
Type IV atherosclerotic lesion- MedGen UID:
- 1632011
- •Concept ID:
- C4703375
- •
- Disease or Syndrome
In type IV atherosclerotic lesions a dense accumulation of extracellular lipid occupies an extensive but well-defined region of the intima. This type of extracellular lipid accumulation is known as the lipid core. A fibrous tissue increase is not a feature, and complications such as defects of the lesion surface and thrombosis are not present. The type IV lesion is also known as atheroma. Type IV is the first lesion considered advanced in this classification because of the severe intimal disorganization caused by the lipid core. The characteristic core appears to develop from an increase and the consequent confluence of the small isolated pools of extracellular lipid that characterize type III lesions. The increase in lipid is believed to result from continued insudation from the plasma. Type IV lesions, when they first appear in younger people, are found in the same locations as adaptive intimal thickenings of the eccentric type. Thus, atheroma is, at least initially, an eccentric lesion.
Hearing impairment- MedGen UID:
- 235586
- •Concept ID:
- C1384666
- •
- Disease or Syndrome
A decreased magnitude of the sensory perception of sound.
Hypercholesterolemia- MedGen UID:
- 5687
- •Concept ID:
- C0020443
- •
- Disease or Syndrome
An increased concentration of cholesterol in the blood.
Increased LDL cholesterol concentration- MedGen UID:
- 154289
- •Concept ID:
- C0549399
- •
- Finding
An elevated concentration of low-density lipoprotein cholesterol in the blood.
Hypertriglyceridemia- MedGen UID:
- 167238
- •Concept ID:
- C0813230
- •
- Finding
An abnormal increase in the level of triglycerides in the blood.
Abnormality of the skin- MedGen UID:
- 1845238
- •Concept ID:
- C5848159
- •
- Anatomical Abnormality
An abnormality of the skin.
Corneal arcus- MedGen UID:
- 8179
- •Concept ID:
- C0003742
- •
- Finding
A hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years.
- Abnormality of metabolism/homeostasis
- Abnormality of the cardiovascular system
- Abnormality of the ear
- Abnormality of the eye
- Abnormality of the integument