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Dyslexia, susceptibility to, 2(DYX2)

MedGen UID:
325025
Concept ID:
C1838436
Finding
Synonyms: Dyslexia 2; READING DISABILITY, SPECIFIC, 2
 
Monarch Initiative: MONDO:0010843
OMIM®: 600202

Clinical features

From HPO
Dyslexia
MedGen UID:
96906
Concept ID:
C0476254
Mental or Behavioral Dysfunction
A learning disorder characterized primarily by difficulties in learning to read and spell. Dyslectic children also exhibit a tendency to read words from right to left and to confuse letters such as b and d whose orientation is important for their identification. Children with dyslexia appear to be impaired in phonemic skills (the ability to associate visual symbols with the sounds they represent).
  • Abnormality of the nervous system

Professional guidelines

PubMed

Morin G, Biancalana V, Echaniz-Laguna A, Noury JB, Lornage X, Moggio M, Ripolone M, Violano R, Marcorelles P, Maréchal D, Renaud F, Maurage CA, Tard C, Cuisset JM, Laporte J, Böhm J
Hum Mutat 2020 Jan;41(1):17-37. Epub 2019 Sep 15 doi: 10.1002/humu.23899. PMID: 31448844
Trezzi V, Forni D, Giorda R, Villa M, Molteni M, Marino C, Mascheretti S
J Hum Genet 2017 Nov;62(11):949-955. Epub 2017 Aug 3 doi: 10.1038/jhg.2017.80. PMID: 29066855

Recent clinical studies

Etiology

Zhu K, Liu Q, Xie X, Jiang Q, Feng Y, Xiao P, Wu X, Zhu B, Song R
Neurotoxicology 2022 Sep;92:102-109. Epub 2022 Aug 5 doi: 10.1016/j.neuro.2022.08.004. PMID: 35940320
Cardoso C, Afonso C, Bandarra NM
Nutr Res Rev 2016 Dec;29(2):281-294. Epub 2016 Nov 21 doi: 10.1017/S0954422416000184. PMID: 27866493
Ozernov-Palchik O, Gaab N
Wiley Interdiscip Rev Cogn Sci 2016 Mar-Apr;7(2):156-76. Epub 2016 Feb 2 doi: 10.1002/wcs.1383. PMID: 26836227Free PMC Article
Mather DS, Milford TM, Mcrae LM
Percept Mot Skills 2015 Oct;121(2):569-601. Epub 2015 Oct 16 doi: 10.2466/15.10.PMS.121c21x5. PMID: 26474440
Rodenas-Cuadrado P, Ho J, Vernes SC
Eur J Hum Genet 2014 Feb;22(2):171-8. Epub 2013 May 29 doi: 10.1038/ejhg.2013.100. PMID: 23714751Free PMC Article

Diagnosis

Morin G, Biancalana V, Echaniz-Laguna A, Noury JB, Lornage X, Moggio M, Ripolone M, Violano R, Marcorelles P, Maréchal D, Renaud F, Maurage CA, Tard C, Cuisset JM, Laporte J, Böhm J
Hum Mutat 2020 Jan;41(1):17-37. Epub 2019 Sep 15 doi: 10.1002/humu.23899. PMID: 31448844
Ozernov-Palchik O, Gaab N
Wiley Interdiscip Rev Cogn Sci 2016 Mar-Apr;7(2):156-76. Epub 2016 Feb 2 doi: 10.1002/wcs.1383. PMID: 26836227Free PMC Article
Mather DS, Milford TM, Mcrae LM
Percept Mot Skills 2015 Oct;121(2):569-601. Epub 2015 Oct 16 doi: 10.2466/15.10.PMS.121c21x5. PMID: 26474440
Torppa M, Eklund K, van Bergen E, Lyytinen H
J Abnorm Child Psychol 2015 Oct;43(7):1389-401. doi: 10.1007/s10802-015-0003-1. PMID: 25772426
McGrath LM, Smith SD, Pennington BF
Trends Mol Med 2006 Jul;12(7):333-41. Epub 2006 Jun 16 doi: 10.1016/j.molmed.2006.05.007. PMID: 16781891

Therapy

Zhu K, Liu Q, Xie X, Jiang Q, Feng Y, Xiao P, Wu X, Zhu B, Song R
Neurotoxicology 2022 Sep;92:102-109. Epub 2022 Aug 5 doi: 10.1016/j.neuro.2022.08.004. PMID: 35940320
Yeung SS, Savage R
J Learn Disabil 2020 Mar/Apr;53(2):131-144. Epub 2019 Dec 21 doi: 10.1177/0022219419894563. PMID: 31868074
Cardoso C, Afonso C, Bandarra NM
Nutr Res Rev 2016 Dec;29(2):281-294. Epub 2016 Nov 21 doi: 10.1017/S0954422416000184. PMID: 27866493
Dahdouh F, Anthoni H, Tapia-Páez I, Peyrard-Janvid M, Schulte-Körne G, Warnke A, Remschmidt H, Ziegler A, Kere J, Müller-Myhsok B, Nöthen MM, Schumacher J, Zucchelli M
Psychiatr Genet 2009 Apr;19(2):59-63. doi: 10.1097/YPG.0b013e32832080e1. PMID: 19240663
Harold D, Paracchini S, Scerri T, Dennis M, Cope N, Hill G, Moskvina V, Walter J, Richardson AJ, Owen MJ, Stein JF, Green ED, O'Donovan MC, Williams J, Monaco AP
Mol Psychiatry 2006 Dec;11(12):1085-91, 1061. Epub 2006 Oct 10 doi: 10.1038/sj.mp.4001904. PMID: 17033633

Prognosis

Torppa M, Vasalampi K, Eklund K, Niemi P
J Exp Child Psychol 2022 Mar;215:105314. Epub 2021 Nov 16 doi: 10.1016/j.jecp.2021.105314. PMID: 34798592
Torppa M, Eklund K, van Bergen E, Lyytinen H
J Abnorm Child Psychol 2015 Oct;43(7):1389-401. doi: 10.1007/s10802-015-0003-1. PMID: 25772426
Veerappa AM, Saldanha M, Padakannaya P, Ramachandra NB
Am J Med Genet B Neuropsychiatr Genet 2014 Oct;165B(7):572-80. Epub 2014 Aug 19 doi: 10.1002/ajmg.b.32260. PMID: 25139666
Boets B, De Smedt B, Cleuren L, Vandewalle E, Wouters J, Ghesquière P
Br J Dev Psychol 2010 Mar;28(Pt 1):5-31. doi: 10.1348/026151010x485223. PMID: 20306623
McGrath LM, Smith SD, Pennington BF
Trends Mol Med 2006 Jul;12(7):333-41. Epub 2006 Jun 16 doi: 10.1016/j.molmed.2006.05.007. PMID: 16781891

Clinical prediction guides

Mioli A, Diolaiuti F, Zangrandi A, Orsini P, Sebastiani L, Santarcangelo EL
Int J Clin Exp Hypn 2021 Apr-Jun;69(2):215-224. Epub 2021 Feb 9 doi: 10.1080/00207144.2021.1877089. PMID: 33560171
Liu Q, Zhu B, Xue Q, Xie X, Zhou Y, Zhu K, Wan Z, Wu H, Zhang J, Song R
Environ Res 2020 Dec;191:110207. Epub 2020 Sep 13 doi: 10.1016/j.envres.2020.110207. PMID: 32937172
Gabel LA, Manglani M, Escalona N, Cysner J, Hamilton R, Pfaffmann J, Johnson E
Ann Dyslexia 2016 Oct;66(3):319-336. Epub 2016 Mar 24 doi: 10.1007/s11881-016-0125-3. PMID: 27013331
Torppa M, Eklund K, van Bergen E, Lyytinen H
J Abnorm Child Psychol 2015 Oct;43(7):1389-401. doi: 10.1007/s10802-015-0003-1. PMID: 25772426
McGrath LM, Smith SD, Pennington BF
Trends Mol Med 2006 Jul;12(7):333-41. Epub 2006 Jun 16 doi: 10.1016/j.molmed.2006.05.007. PMID: 16781891

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