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Common cold

MedGen UID:
3179
•Concept ID:
C0009443
•
Disease or Syndrome
Synonyms: Cold, Common; Colds, Common; Common Cold; Common Colds
SNOMED CT: Common cold (82272006); Acute coryza (82272006); Acute nasal catarrh (82272006); Acute rhinitis (82272006); Infective rhinitis (82272006); Acute nasopharyngitis (82272006); Infective nasopharyngitis (82272006); Head cold (82272006); Acute infective rhinitis (82272006); Cold (82272006)
 
Monarch Initiative: MONDO:0005709

Definition

An acute inflammatory process that affects the nasopharynx. It is caused by viruses. Signs and symptoms include fever, coughing, sneezing, and sore throat. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCommon cold

Professional guidelines

PubMed

The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19.
Cerullo G, Negro M, Parimbelli M, Pecoraro M, Perna S, Liguori G, Rondanelli M, Cena H, D'Antona G
Front Immunol 2020;11:574029. Epub 2020 Oct 28 doi: 10.3389/fimmu.2020.574029. PMID: 33193359Free PMC Article
Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020.
Jaume F, Valls-Mateus M, Mullol J
Curr Allergy Asthma Rep 2020 Jun 3;20(7):28. doi: 10.1007/s11882-020-00917-5. PMID: 32495003Free PMC Article
Treatment of the Common Cold.
DeGeorge KC, Ring DJ, Dalrymple SN
Am Fam Physician 2019 Sep 1;100(5):281-289. PMID: 31478634

Recent clinical studies

Etiology

Zinc for prevention and treatment of the common cold.
Nault D, Machingo TA, Shipper AG, Antiporta DA, Hamel C, Nourouzpour S, Konstantinidis M, Phillips E, Lipski EA, Wieland LS
Cochrane Database Syst Rev 2024 May 9;5(5):CD014914. doi: 10.1002/14651858.CD014914.pub2. PMID: 38719213Free PMC Article
Behaviorally Assessed Sleep and Susceptibility to the Common Cold.
Prather AA, Janicki-Deverts D, Hall MH, Cohen S
Sleep 2015 Sep 1;38(9):1353-9. doi: 10.5665/sleep.4968. PMID: 26118561Free PMC Article
Echinacea for preventing and treating the common cold.
Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K
Cochrane Database Syst Rev 2014 Feb 20;2014(2):CD000530. doi: 10.1002/14651858.CD000530.pub3. PMID: 24554461Free PMC Article
Vitamin C for preventing and treating the common cold.
Hemilä H, Chalker E
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD000980. doi: 10.1002/14651858.CD000980.pub4. PMID: 23440782Free PMC Article
Upper respiratory tract infections.
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article

Diagnosis

Comparison of the clinical differences between COVID-19, SARS, influenza, and the common cold: A systematic literature review.
Czubak J, Stolarczyk K, Orzeł A, Frączek M, Zatoński T
Adv Clin Exp Med 2021 Jan;30(1):109-114. doi: 10.17219/acem/129573. PMID: 33529514
Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020.
Jaume F, Valls-Mateus M, Mullol J
Curr Allergy Asthma Rep 2020 Jun 3;20(7):28. doi: 10.1007/s11882-020-00917-5. PMID: 32495003Free PMC Article
Common cold.
Worrall G
Can Fam Physician 2011 Nov;57(11):1289-90. PMID: 22084460Free PMC Article
Understanding the symptoms of the common cold and influenza.
Eccles R
Lancet Infect Dis 2005 Nov;5(11):718-25. doi: 10.1016/S1473-3099(05)70270-X. PMID: 16253889Free PMC Article
Upper respiratory tract infections.
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article

Therapy

Zinc for prevention and treatment of the common cold.
Nault D, Machingo TA, Shipper AG, Antiporta DA, Hamel C, Nourouzpour S, Konstantinidis M, Phillips E, Lipski EA, Wieland LS
Cochrane Database Syst Rev 2024 May 9;5(5):CD014914. doi: 10.1002/14651858.CD014914.pub2. PMID: 38719213Free PMC Article
Vitamin C reduces the severity of common colds: a meta-analysis.
Hemilä H, Chalker E
BMC Public Health 2023 Dec 11;23(1):2468. doi: 10.1186/s12889-023-17229-8. PMID: 38082300Free PMC Article
Echinacea for preventing and treating the common cold.
Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K
Cochrane Database Syst Rev 2014 Feb 20;2014(2):CD000530. doi: 10.1002/14651858.CD000530.pub3. PMID: 24554461Free PMC Article
Vitamin C for preventing and treating the common cold.
Hemilä H, Chalker E
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD000980. doi: 10.1002/14651858.CD000980.pub4. PMID: 23440782Free PMC Article
Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis.
Shah SA, Sander S, White CM, Rinaldi M, Coleman CI
Lancet Infect Dis 2007 Jul;7(7):473-80. doi: 10.1016/S1473-3099(07)70160-3. PMID: 17597571Free PMC Article

Prognosis

Architecture of the SARS-CoV-2-specific T cell repertoire.
Zornikova KV, Sheetikov SA, Rusinov AY, Iskhakov RN, Bogolyubova AV
Front Immunol 2023;14:1070077. Epub 2023 Mar 20 doi: 10.3389/fimmu.2023.1070077. PMID: 37020560Free PMC Article
Vaccines for the common cold.
Montesinos-Guevara C, Buitrago-Garcia D, Felix ML, Guerra CV, Hidalgo R, Martinez-Zapata MJ, Simancas-Racines D
Cochrane Database Syst Rev 2022 Dec 14;12(12):CD002190. doi: 10.1002/14651858.CD002190.pub6. PMID: 36515550Free PMC Article
Zinc Supplementation Reduces Common Cold Duration among Healthy Adults: A Systematic Review of Randomized Controlled Trials with Micronutrients Supplementation.
Wang MX, Win SS, Pang J
Am J Trop Med Hyg 2020 Jul;103(1):86-99. Epub 2020 Apr 23 doi: 10.4269/ajtmh.19-0718. PMID: 32342851Free PMC Article
Behaviorally Assessed Sleep and Susceptibility to the Common Cold.
Prather AA, Janicki-Deverts D, Hall MH, Cohen S
Sleep 2015 Sep 1;38(9):1353-9. doi: 10.5665/sleep.4968. PMID: 26118561Free PMC Article
The common cold.
Heikkinen T, Järvinen A
Lancet 2003 Jan 4;361(9351):51-9. doi: 10.1016/S0140-6736(03)12162-9. PMID: 12517470Free PMC Article

Clinical prediction guides

Nasal decongestants in monotherapy for the common cold.
Deckx L, De Sutter AI, Guo L, Mir NA, van Driel ML
Cochrane Database Syst Rev 2016 Oct 17;10(10):CD009612. doi: 10.1002/14651858.CD009612.pub2. PMID: 27748955Free PMC Article
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.
Tiralongo E, Wee SS, Lea RA
Nutrients 2016 Mar 24;8(4):182. doi: 10.3390/nu8040182. PMID: 27023596Free PMC Article
Behaviorally Assessed Sleep and Susceptibility to the Common Cold.
Prather AA, Janicki-Deverts D, Hall MH, Cohen S
Sleep 2015 Sep 1;38(9):1353-9. doi: 10.5665/sleep.4968. PMID: 26118561Free PMC Article
Saline nasal irrigation for acute upper respiratory tract infections.
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article
Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis.
Shah SA, Sander S, White CM, Rinaldi M, Coleman CI
Lancet Infect Dis 2007 Jul;7(7):473-80. doi: 10.1016/S1473-3099(07)70160-3. PMID: 17597571Free PMC Article

Recent systematic reviews

Zinc for prevention and treatment of the common cold.
Nault D, Machingo TA, Shipper AG, Antiporta DA, Hamel C, Nourouzpour S, Konstantinidis M, Phillips E, Lipski EA, Wieland LS
Cochrane Database Syst Rev 2024 May 9;5(5):CD014914. doi: 10.1002/14651858.CD014914.pub2. PMID: 38719213Free PMC Article
Oral antihistamine-decongestant-analgesic combinations for the common cold.
De Sutter AI, Eriksson L, van Driel ML
Cochrane Database Syst Rev 2022 Jan 21;1(1):CD004976. doi: 10.1002/14651858.CD004976.pub4. PMID: 35060618Free PMC Article
Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report.
Malesker MA, Callahan-Lyon P, Ireland B, Irwin RS; CHEST Expert Cough Panel
Chest 2017 Nov;152(5):1021-1037. Epub 2017 Aug 22 doi: 10.1016/j.chest.2017.08.009. PMID: 28837801Free PMC Article
Echinacea for preventing and treating the common cold.
Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K
Cochrane Database Syst Rev 2014 Feb 20;2014(2):CD000530. doi: 10.1002/14651858.CD000530.pub3. PMID: 24554461Free PMC Article
Vitamin C for preventing and treating the common cold.
Hemilä H, Chalker E
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD000980. doi: 10.1002/14651858.CD000980.pub4. PMID: 23440782Free PMC Article

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