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Increased Drug AUC

MedGen UID:
313305
•Concept ID:
C1708492
•
Finding
Synonyms: Increased Area Under Curve; Increased AUC; Increased Drug Area Under Curve

Definition

Increased area under the plot of plasma concentration of a drug against time after drug administration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased Drug AUC

Professional guidelines

PubMed

Systematic review of drug-drug interactions between rifamycins and anticoagulant and antiplatelet agents and considerations for management.
MacDougall C, Canonica T, Keh C, P Phan BA, Louie J
Pharmacotherapy 2022 Apr;42(4):343-361. Epub 2022 Feb 28 doi: 10.1002/phar.2672. PMID: 35152432
The Treatment of Tuberculosis.
Peloquin CA, Davies GR
Clin Pharmacol Ther 2021 Dec;110(6):1455-1466. Epub 2021 Jun 5 doi: 10.1002/cpt.2261. PMID: 33837535
Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin-Resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists.
Rybak MJ, Le J, Lodise TP, Levine DP, Bradley JS, Liu C, Mueller BA, Pai MP, Wong-Beringer A, Rotschafer JC, Rodvold KA, Maples HD, Lomaestro BM
Pharmacotherapy 2020 Apr;40(4):363-367. Epub 2020 Mar 29 doi: 10.1002/phar.2376. PMID: 32227354

Recent clinical studies

Etiology

The effect of anti-tuberculosis drug pharmacokinetics on QTc prolongation.
Jin Y, Benkeser D, Kipiani M, Maranchick NF, Mikiashvili L, Barbakadze K, Avaliani Z, Alghamdi WA, Alshaer MH, Peloquin CA, Blumberg HM, Kempker RR
Int J Antimicrob Agents 2023 Oct;62(4):106939. Epub 2023 Jul 29 doi: 10.1016/j.ijantimicag.2023.106939. PMID: 37517627Free PMC Article
Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants.
Bansal S, Zamarripa CA, Spindle TR, Weerts EM, Thummel KE, Vandrey R, Paine MF, Unadkat JD
Clin Pharmacol Ther 2023 Sep;114(3):693-703. Epub 2023 Jun 30 doi: 10.1002/cpt.2973. PMID: 37313955Free PMC Article
Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial.
Atila C, Holze F, Murugesu R, Rommers N, Hutter N, Varghese N, Sailer CO, Eckert A, Heinrichs M, Liechti ME, Christ-Crain M
Lancet Diabetes Endocrinol 2023 Jul;11(7):454-464. Epub 2023 May 13 doi: 10.1016/S2213-8587(23)00120-1. PMID: 37192642
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects.
Taylor L, Gidal B, Blakey G, Tayo B, Morrison G
CNS Drugs 2018 Nov;32(11):1053-1067. doi: 10.1007/s40263-018-0578-5. PMID: 30374683Free PMC Article
Clinical Pharmacokinetics and Pharmacodynamics of Lenalidomide.
Chen N, Zhou S, Palmisano M
Clin Pharmacokinet 2017 Feb;56(2):139-152. doi: 10.1007/s40262-016-0432-1. PMID: 27351179Free PMC Article

Diagnosis

Clinical pharmacokinetics of nebivolol: a systematic review.
Hanif N, Zamir A, Imran I, Saeed H, Majeed A, Rehman AU, Ashraf W, Alqahtani F, Rasool MF
Drug Metab Rev 2023 Nov;55(4):428-440. Epub 2023 Oct 28 doi: 10.1080/03602532.2023.2271195. PMID: 37849071
Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy.
Amaeze OU, Isoherranen N
Clin Transl Sci 2023 Nov;16(11):2163-2176. Epub 2023 Sep 15 doi: 10.1111/cts.13614. PMID: 37712488Free PMC Article
The Treatment of Tuberculosis.
Peloquin CA, Davies GR
Clin Pharmacol Ther 2021 Dec;110(6):1455-1466. Epub 2021 Jun 5 doi: 10.1002/cpt.2261. PMID: 33837535
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy JP, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P, Blennow K
Lancet Neurol 2020 May;19(5):422-433. doi: 10.1016/S1474-4422(20)30071-5. PMID: 32333900
A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations.
Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, Purnell JQ
Am J Clin Nutr 2005 Jul;82(1):41-8. doi: 10.1093/ajcn.82.1.41. PMID: 16002798

Therapy

Gepirone hydrochloride: a novel antidepressant with 5-HT1A agonistic properties.
Kaur Gill A, Bansal Y, Bhandari R, Kaur S, Kaur J, Singh R, Kuhad A, Kuhad A
Drugs Today (Barc) 2019 Jul;55(7):423-437. doi: 10.1358/dot.2019.55.7.2958474. PMID: 31347611
Capecitabine: a review.
Walko CM, Lindley C
Clin Ther 2005 Jan;27(1):23-44. doi: 10.1016/j.clinthera.2005.01.005. PMID: 15763604
Clinical pharmacokinetics of everolimus.
Kirchner GI, Meier-Wiedenbach I, Manns MP
Clin Pharmacokinet 2004;43(2):83-95. doi: 10.2165/00003088-200443020-00002. PMID: 14748618
Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies.
Gabizon A, Shmeeda H, Barenholz Y
Clin Pharmacokinet 2003;42(5):419-36. doi: 10.2165/00003088-200342050-00002. PMID: 12739982
Clinical pharmacokinetics of naproxen.
Davies NM, Anderson KE
Clin Pharmacokinet 1997 Apr;32(4):268-93. doi: 10.2165/00003088-199732040-00002. PMID: 9113437

Prognosis

A systematic review of artificial intelligence algorithms for predicting acute kidney injury.
Bacci MR, Minczuk CVB, Fonseca FLA
Eur Rev Med Pharmacol Sci 2023 Oct;27(20):9872-9879. doi: 10.26355/eurrev_202310_34164. PMID: 37916354
Clinical Pharmacokinetics and Pharmacodynamics of Rifampicin in Human Tuberculosis.
Abulfathi AA, Decloedt EH, Svensson EM, Diacon AH, Donald P, Reuter H
Clin Pharmacokinet 2019 Sep;58(9):1103-1129. doi: 10.1007/s40262-019-00764-2. PMID: 31049868
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers.
Trebeschi S, Drago SG, Birkbak NJ, Kurilova I, Cǎlin AM, Delli Pizzi A, Lalezari F, Lambregts DMJ, Rohaan MW, Parmar C, Rozeman EA, Hartemink KJ, Swanton C, Haanen JBAG, Blank CU, Smit EF, Beets-Tan RGH, Aerts HJWL
Ann Oncol 2019 Jun 1;30(6):998-1004. doi: 10.1093/annonc/mdz108. PMID: 30895304Free PMC Article
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.
Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K; GWPCARE1 Part A Study Group
Neurology 2018 Apr 3;90(14):e1204-e1211. Epub 2018 Mar 14 doi: 10.1212/WNL.0000000000005254. PMID: 29540584Free PMC Article
Pharmacokinetic/pharmacodynamic profile of voriconazole.
Theuretzbacher U, Ihle F, Derendorf H
Clin Pharmacokinet 2006;45(7):649-63. doi: 10.2165/00003088-200645070-00002. PMID: 16802848

Clinical prediction guides

A systematic review of artificial intelligence algorithms for predicting acute kidney injury.
Bacci MR, Minczuk CVB, Fonseca FLA
Eur Rev Med Pharmacol Sci 2023 Oct;27(20):9872-9879. doi: 10.26355/eurrev_202310_34164. PMID: 37916354
The effect of anti-tuberculosis drug pharmacokinetics on QTc prolongation.
Jin Y, Benkeser D, Kipiani M, Maranchick NF, Mikiashvili L, Barbakadze K, Avaliani Z, Alghamdi WA, Alshaer MH, Peloquin CA, Blumberg HM, Kempker RR
Int J Antimicrob Agents 2023 Oct;62(4):106939. Epub 2023 Jul 29 doi: 10.1016/j.ijantimicag.2023.106939. PMID: 37517627Free PMC Article
Development and Validation of a Computed Tomography-Based Radiomics Signature to Predict Response to Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer.
Wang W, Peng Y, Feng X, Zhao Y, Seeruttun SR, Zhang J, Cheng Z, Li Y, Liu Z, Zhou Z
JAMA Netw Open 2021 Aug 2;4(8):e2121143. doi: 10.1001/jamanetworkopen.2021.21143. PMID: 34410397Free PMC Article
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers.
Trebeschi S, Drago SG, Birkbak NJ, Kurilova I, Cǎlin AM, Delli Pizzi A, Lalezari F, Lambregts DMJ, Rohaan MW, Parmar C, Rozeman EA, Hartemink KJ, Swanton C, Haanen JBAG, Blank CU, Smit EF, Beets-Tan RGH, Aerts HJWL
Ann Oncol 2019 Jun 1;30(6):998-1004. doi: 10.1093/annonc/mdz108. PMID: 30895304Free PMC Article
Clinical Pharmacokinetics of Paritaprevir.
Menon RM, Polepally AR, Khatri A, Awni WM, Dutta S
Clin Pharmacokinet 2017 Oct;56(10):1125-1137. doi: 10.1007/s40262-017-0520-x. PMID: 28236252

Recent systematic reviews

Clinical pharmacokinetics of nebivolol: a systematic review.
Hanif N, Zamir A, Imran I, Saeed H, Majeed A, Rehman AU, Ashraf W, Alqahtani F, Rasool MF
Drug Metab Rev 2023 Nov;55(4):428-440. Epub 2023 Oct 28 doi: 10.1080/03602532.2023.2271195. PMID: 37849071
Clinical Pharmacokinetics of Metoprolol: A Systematic Review.
Zamir A, Hussain I, Ur Rehman A, Ashraf W, Imran I, Saeed H, Majeed A, Alqahtani F, Rasool MF
Clin Pharmacokinet 2022 Aug;61(8):1095-1114. Epub 2022 Jun 28 doi: 10.1007/s40262-022-01145-y. PMID: 35764772
Systematic review of drug-drug interactions between rifamycins and anticoagulant and antiplatelet agents and considerations for management.
MacDougall C, Canonica T, Keh C, P Phan BA, Louie J
Pharmacotherapy 2022 Apr;42(4):343-361. Epub 2022 Feb 28 doi: 10.1002/phar.2672. PMID: 35152432
The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing.
Tsutsuura M, Moriyama H, Kojima N, Mizukami Y, Tashiro S, Osa S, Enoki Y, Taguchi K, Oda K, Fujii S, Takahashi Y, Hamada Y, Kimura T, Takesue Y, Matsumoto K
BMC Infect Dis 2021 Feb 6;21(1):153. doi: 10.1186/s12879-021-05858-6. PMID: 33549035Free PMC Article
Pharmacokinetics and Target Attainment of Antibiotics in Critically Ill Children: A Systematic Review of Current Literature.
Hartman SJF, Brüggemann RJ, Orriëns L, Dia N, Schreuder MF, de Wildt SN
Clin Pharmacokinet 2020 Feb;59(2):173-205. doi: 10.1007/s40262-019-00813-w. PMID: 31432468Free PMC Article

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