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Ovarian Sertoli Cell Tumor

MedGen UID:
311375
•Concept ID:
C1519663
•
Neoplastic Process

Definition

A rare, typically benign ovarian neoplasm composed of Sertoli cells. Patients may present with pseudoprecocity, menometrorrhagia, amenorrhea, hirsutism, and hoarseness. Rarely it may invade the ovarian stroma and extend beyond the ovary. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Sertoli Cell Tumor

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor.
Zhao C, Barner R, Vinh TN, McManus K, Dabbs D, Vang R
Int J Gynecol Pathol 2008 Oct;27(4):507-14. doi: 10.1097/PGP.0b013e31817c1b0a. PMID: 18753972
Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis.
Zhao C, Bratthauer GL, Barner R, Vang R
Int J Gynecol Pathol 2007 Jan;26(1):1-9. doi: 10.1097/01.pgp.0000232026.22861.b5. PMID: 17197889

Recent clinical studies

Etiology

SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor.
Zhao C, Barner R, Vinh TN, McManus K, Dabbs D, Vang R
Int J Gynecol Pathol 2008 Oct;27(4):507-14. doi: 10.1097/PGP.0b013e31817c1b0a. PMID: 18753972
Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis.
Zhao C, Bratthauer GL, Barner R, Vang R
Int J Gynecol Pathol 2007 Jan;26(1):1-9. doi: 10.1097/01.pgp.0000232026.22861.b5. PMID: 17197889
Uterine tumor resembling ovarian sex cord tumors: report of a case with ultrastructural study.
Kantelip B, Cloup N, Dechelotte P
Hum Pathol 1986 Jan;17(1):91-4. doi: 10.1016/s0046-8177(86)80161-7. PMID: 3943854

Diagnosis

Ovarian Sertoli Cell Tumor with Immature Prepubertal-like Sertoli Cell Component: A Case Report and Literature Review.
Bužinskienė D, Šidlovska E, Vilutytė G
Medicina (Kaunas) 2022 Nov 13;58(11) doi: 10.3390/medicina58111638. PMID: 36422177Free PMC Article
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review.
Ning Y, Kong F, Cragun JM, Zheng W
Int J Clin Exp Pathol 2013;6(3):516-20. Epub 2013 Feb 15 PMID: 23412916Free PMC Article
SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor.
Zhao C, Barner R, Vinh TN, McManus K, Dabbs D, Vang R
Int J Gynecol Pathol 2008 Oct;27(4):507-14. doi: 10.1097/PGP.0b013e31817c1b0a. PMID: 18753972
Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.
Zhao C, Bratthauer GL, Barner R, Vang R
Am J Surg Pathol 2007 Sep;31(9):1378-86. doi: 10.1097/PAS.0b013e3180339961. PMID: 17721194
Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis.
Zhao C, Bratthauer GL, Barner R, Vang R
Int J Gynecol Pathol 2007 Jan;26(1):1-9. doi: 10.1097/01.pgp.0000232026.22861.b5. PMID: 17197889

Prognosis

Ovarian Sertoli Cell Tumor with Immature Prepubertal-like Sertoli Cell Component: A Case Report and Literature Review.
Bužinskienė D, Šidlovska E, Vilutytė G
Medicina (Kaunas) 2022 Nov 13;58(11) doi: 10.3390/medicina58111638. PMID: 36422177Free PMC Article
Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.
Zhao C, Bratthauer GL, Barner R, Vang R
Am J Surg Pathol 2007 Sep;31(9):1378-86. doi: 10.1097/PAS.0b013e3180339961. PMID: 17721194

Clinical prediction guides

SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor.
Zhao C, Barner R, Vinh TN, McManus K, Dabbs D, Vang R
Int J Gynecol Pathol 2008 Oct;27(4):507-14. doi: 10.1097/PGP.0b013e31817c1b0a. PMID: 18753972
Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.
Zhao C, Bratthauer GL, Barner R, Vang R
Am J Surg Pathol 2007 Sep;31(9):1378-86. doi: 10.1097/PAS.0b013e3180339961. PMID: 17721194
Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases.
Zhao C, Bratthauer GL, Barner R, Vang R
Am J Surg Pathol 2007 Feb;31(2):255-66. doi: 10.1097/01.pas.0000213355.72638.f4. PMID: 17255771
Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis.
Zhao C, Bratthauer GL, Barner R, Vang R
Int J Gynecol Pathol 2007 Jan;26(1):1-9. doi: 10.1097/01.pgp.0000232026.22861.b5. PMID: 17197889
Isochromosome 1q as the sole karyotypic abnormality in a Sertoli cell tumor of the ovary.
Pejovic T, Heim S, Alm P, Iosif S, Himmelmann A, Skjaerris J, Mitelman F
Cancer Genet Cytogenet 1993 Jan;65(1):79-80. doi: 10.1016/0165-4608(93)90065-t. PMID: 8431922

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