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Acidophil Stem Cell Pituitary Neuroendocrine Tumor

MedGen UID:
310446
•Concept ID:
C1706698
•
Neoplastic Process
Synonyms: Acidophil Stem Cell Adenoma; Acidophil Stem Cell PitNET/Adenoma; Acidophil Stem Cell Pituitary Neuroendocrine Tumor/Adenoma

Definition

An infrequent pituitary neuroendocrine tumor composed of cells showing immunoreactivity for prolactin and less often growth hormone. Electron microscopic studies reveal giant mitochondria, a finding not present in any other type of pituitary gland adenomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcidophil Stem Cell Pituitary Neuroendocrine Tumor

Recent clinical studies

Etiology

Pituitary tumours without distinct lineage differentiation express stem cell marker SOX2.
Lenders NF, Thompson TJ, Chui J, Low J, Inder WJ, Earls PE, McCormack AI
Pituitary 2024 Jun;27(3):248-258. Epub 2024 Mar 14 doi: 10.1007/s11102-024-01385-0. PMID: 38483762Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Follicular cells in pituitary neuroendocrine tumors.
Delfin L, Mete O, Asa SL
Hum Pathol 2021 Aug;114:1-8. Epub 2021 May 12 doi: 10.1016/j.humpath.2021.05.002. PMID: 33991528
Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician.
Gomez-Hernandez K, Ezzat S, Asa SL, Mete Ö
Turk Patoloji Derg 2015;31 Suppl 1:4-17. doi: 10.5146/tjpath.2015.01311. PMID: 26177314
A clinicomorphological study of pituitary tumors associated with the clinical syndrome of acromegaly.
Andreeva M, Georgiev T, Bosadjieva E, Karagiosov L, Karagiosov K, Tomova A, Matrosov P, Kirilov G, Diankov L, Christova T
Exp Clin Endocrinol 1991;98(3):223-7. doi: 10.1055/s-0029-1211121. PMID: 1778242

Diagnosis

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Acidophil stem cell pituitary adenoma: a case report and literature review.
Annapurni A, Rathi M
Hormones (Athens) 2019 Dec;18(4):507-512. Epub 2019 Nov 13 doi: 10.1007/s42000-019-00154-0. PMID: 31721135
Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician.
Gomez-Hernandez K, Ezzat S, Asa SL, Mete Ö
Turk Patoloji Derg 2015;31 Suppl 1:4-17. doi: 10.5146/tjpath.2015.01311. PMID: 26177314
Hormone secretion in vitro by plurihormonal pituitary adenomas of the acidophil cell line.
Asa SL, Kovacs K, Horvath E, Singer W, Smyth HS
J Clin Endocrinol Metab 1992 Jul;75(1):68-75. doi: 10.1210/jcem.75.1.1352308. PMID: 1352308
Acidophil stem cell adenoma of the human pituitary: clinicopathologic analysis of 15 cases.
Horvath E, Kovacs K, Singer W, Smyth HS, Killinger DW, Erzin C, Weiss MH
Cancer 1981 Feb 15;47(4):761-71. doi: 10.1002/1097-0142(19810215)47:4<761::aid-cncr2820470422>3.0.co;2-l. PMID: 6261917

Therapy

A case of fugitive acromegaly, initially presented as invasive prolactinoma.
Lim JS, Ku CR, Lee MK, Kim TS, Kim SH, Lee EJ
Endocrine 2010 Aug;38(1):1-5. Epub 2010 Apr 24 doi: 10.1007/s12020-010-9341-5. PMID: 20960094
Long-acting peptidomimergic control of gigantism caused by pituitary acidophilic stem cell adenoma.
Maheshwari HG, Prezant TR, Herman-Bonert V, Shahinian H, Kovacs K, Melmed S
J Clin Endocrinol Metab 2000 Sep;85(9):3409-16. doi: 10.1210/jcem.85.9.6824. PMID: 10999842
Clinical and morphological features of undifferentiated monomorphous GH/TSH-secreting pituitary adenoma.
Skorić T, Korsić M, Zarković K, Plavsić V, Besenski N, Breskovac L, Giljević Z, Paladino J
Eur J Endocrinol 1999 Jun;140(6):528-37. doi: 10.1530/eje.0.1400528. PMID: 10366409
Development of acromegaly during treatment of hyperprolactinemia with bromocriptine: an unusual acidophil stem cell adenoma.
Page MD, Bridges LR, Barth JH, McNichol AM, Belchetz PE
J Clin Endocrinol Metab 1996 Dec;81(12):4484-7. doi: 10.1210/jcem.81.12.8954064. PMID: 8954064

Prognosis

Follicular cells in pituitary neuroendocrine tumors.
Delfin L, Mete O, Asa SL
Hum Pathol 2021 Aug;114:1-8. Epub 2021 May 12 doi: 10.1016/j.humpath.2021.05.002. PMID: 33991528
Epidemiology and biomarker profile of pituitary adenohypophysial tumors.
Mete O, Cintosun A, Pressman I, Asa SL
Mod Pathol 2018 Jun;31(6):900-909. Epub 2018 Feb 12 doi: 10.1038/s41379-018-0016-8. PMID: 29434339
Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician.
Gomez-Hernandez K, Ezzat S, Asa SL, Mete Ö
Turk Patoloji Derg 2015;31 Suppl 1:4-17. doi: 10.5146/tjpath.2015.01311. PMID: 26177314
Cervical lymph nodes metastases from a pituitary carcinoma.
Jamjoom A, Moss T, Coakham H, Jamjoom ZA, Anthony P
Br J Neurosurg 1994;8(1):87-92. doi: 10.3109/02688699409002399. PMID: 8011201
Morphogenesis and significance of fibrous bodies in human pituitary adenomas.
Horvath E, Kovacs K
Virchows Arch B Cell Pathol 1978 Mar 2;27(1):69-78. doi: 10.1007/BF02888984. PMID: 417457

Clinical prediction guides

Epidemiology and biomarker profile of pituitary adenohypophysial tumors.
Mete O, Cintosun A, Pressman I, Asa SL
Mod Pathol 2018 Jun;31(6):900-909. Epub 2018 Feb 12 doi: 10.1038/s41379-018-0016-8. PMID: 29434339
Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician.
Gomez-Hernandez K, Ezzat S, Asa SL, Mete Ö
Turk Patoloji Derg 2015;31 Suppl 1:4-17. doi: 10.5146/tjpath.2015.01311. PMID: 26177314
Pituitary carcinoma: an ultrastructural study of eleven cases.
Scheithauer BW, Fereidooni F, Horvath E, Kovacs K, Robbins P, Tews D, Henry K, Pernicone P, Gaffrey TA Jr, Meyer FB, Young WF Jr, Fahlbusch R, Buchfelder M, Lloyd RV
Ultrastruct Pathol 2001 May-Jun;25(3):227-42. doi: 10.1080/019131201300343865. PMID: 11465479

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