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Ovarian yolk sac tumor, polyvesicular vitelline pattern

MedGen UID:
309521
•Concept ID:
C1518749
•
Neoplastic Process
Synonyms: Ovarian Yolk Sac Tumor, Polyvesicular Vitelline Pattern; ovarian yolk sac tumor, polyvesicular vitelline pattern; polyvesicular vitelline pattern ovarian yolk sac tumor; polyvesicular vitelline pattern ovarian yolk sac tumour
 
Monarch Initiative: MONDO:0003907

Definition

A yolk sac tumor that arises from the ovary and is characterized by the presence of multiple dilated spaces lined by cells that resemble mesothelial cells. The dilated spaces coexist with columnar epithelial tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian yolk sac tumor, polyvesicular vitelline pattern

Recent clinical studies

Etiology

Yolk sac tumors with pure and mixed polyvesicular vitelline patterns.
Nogales FF Jr, Matilla A, Nogales-Ortiz, galera-Davidson HL
Hum Pathol 1978 Sep;9(5):553-66. doi: 10.1016/s0046-8177(78)80136-1. PMID: 711231

Diagnosis

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type.
Ricci C, Ambrosi F, Franceschini T, Giunchi F, Di Filippo G, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Histopathology 2023 Sep;83(3):465-476. Epub 2023 Jun 14 doi: 10.1111/his.14968. PMID: 37317674
Glypican 3 has a higher sensitivity than alpha-fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns.
Zynger DL, McCallum JC, Luan C, Chou PM, Yang XJ
Histopathology 2010 May;56(6):750-7. doi: 10.1111/j.1365-2559.2010.03553.x. PMID: 20546340
Pure yolk sac tumors in genital and extragenital sites: study on three pedriatic cases, with cytological findings on two.
Sironi M, Assi A, Quaglia G, Tonnarelli G, Cozzi L
Adv Clin Path 1999 Jul;3(3):55-62. PMID: 10655574
Morphological analysis of yolk sac tumor.
Ito K
Tohoku J Exp Med 1993 Sep;171(1):53-63. doi: 10.1620/tjem.171.53. PMID: 7510076
Yolk sac tumors with pure and mixed polyvesicular vitelline patterns.
Nogales FF Jr, Matilla A, Nogales-Ortiz, galera-Davidson HL
Hum Pathol 1978 Sep;9(5):553-66. doi: 10.1016/s0046-8177(78)80136-1. PMID: 711231

Therapy

Yolk sac tumors with pure and mixed polyvesicular vitelline patterns.
Nogales FF Jr, Matilla A, Nogales-Ortiz, galera-Davidson HL
Hum Pathol 1978 Sep;9(5):553-66. doi: 10.1016/s0046-8177(78)80136-1. PMID: 711231

Prognosis

Pure yolk sac tumors in genital and extragenital sites: study on three pedriatic cases, with cytological findings on two.
Sironi M, Assi A, Quaglia G, Tonnarelli G, Cozzi L
Adv Clin Path 1999 Jul;3(3):55-62. PMID: 10655574
The endodermal sinus tumor: special features.
Azoury RS, Nasr MF, Muawwad RF
Int J Gynaecol Obstet 1979 Sep-Oct;17(2):164-71. doi: 10.1002/j.1879-3479.1979.tb00142.x. PMID: 41764
Yolk sac tumors with pure and mixed polyvesicular vitelline patterns.
Nogales FF Jr, Matilla A, Nogales-Ortiz, galera-Davidson HL
Hum Pathol 1978 Sep;9(5):553-66. doi: 10.1016/s0046-8177(78)80136-1. PMID: 711231

Clinical prediction guides

Morphological analysis of yolk sac tumor.
Ito K
Tohoku J Exp Med 1993 Sep;171(1):53-63. doi: 10.1620/tjem.171.53. PMID: 7510076
Immunohistochemical characterization of extracellular matrix components of yolk sac tumors.
Nakashima N, Sobue M, Fukata S, Fukatsu T, Nagasaka T, Ohiwa N, Nara Y, Lai S, Takeuchi J
Virchows Arch B Cell Pathol Incl Mol Pathol 1990;58(4):309-15. doi: 10.1007/BF02890086. PMID: 1970695

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