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Pulmonary type ovarian small cell carcinoma

MedGen UID:
309517
•Concept ID:
C1518737
•
Neoplastic Process
Synonyms: ovarian small cell carcinoma, pulmonary type; Ovarian Small Cell Carcinoma, Pulmonary-Type; Ovarian Small Cell NEC; Ovarian Small Cell Neuroendocrine Carcinoma; pulmonary type ovarian small cell carcinoma
 
Monarch Initiative: MONDO:0004318

Definition

An aggressive small cell neuroendocrine carcinoma that arises from the ovary. Morphologically, it resembles the small cell carcinoma that arises from the lung. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary type ovarian small cell carcinoma

Professional guidelines

PubMed

ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers.
Roskoski R Jr
Pharmacol Res 2017 Jul;121:202-212. Epub 2017 Apr 30 doi: 10.1016/j.phrs.2017.04.022. PMID: 28465216
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Recent clinical studies

Etiology

Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.
Chen X, Liu HL, Wang JS, Zhao FH
Chin Med Sci J 2023 Jun 30;38(2):130-137. doi: 10.24920/004183. PMID: 37286512
A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors.
Bauer TM, Moore KN, Rader JS, Simpkins F, Mita AC, Beck JT, Hart L, Chu Q, Oza A, Tinker AV, Imedio ER, Kumar S, Mugundu G, Jenkins S, Chmielecki J, Jones S, Spigel D, Fu S
Target Oncol 2023 Jul;18(4):517-530. Epub 2023 Jun 6 doi: 10.1007/s11523-023-00965-7. PMID: 37278879Free PMC Article
Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Diagnosis

Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.
Chen X, Liu HL, Wang JS, Zhao FH
Chin Med Sci J 2023 Jun 30;38(2):130-137. doi: 10.24920/004183. PMID: 37286512
The important role of miR-770 as a novel potential diagnostic and therapeutic target for human cancer and other diseases.
Khalilian S, Hosseini Imani SZ, Hosseini SA, Ghafouri-Fard S
Pathol Res Pract 2023 Aug;248:154586. Epub 2023 May 29 doi: 10.1016/j.prp.2023.154586. PMID: 37267769
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

Therapy

Efficacy and safety of autologous tumor-infiltrating lymphocytes in recurrent or refractory ovarian cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Amaria R, Knisely A, Vining D, Kopetz S, Overman MJ, Javle M, Antonoff MB, Tzeng CD, Wolff RA, Pant S, Lito K, Rangel K, Fellman B, Yuan Y, Lu KH, Sakellariou-Thompson D, Haymaker CL, Forget MA, Hwu P, Bernatchez C, Jazaeri AA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-006822. PMID: 38309721Free PMC Article
A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors.
Bauer TM, Moore KN, Rader JS, Simpkins F, Mita AC, Beck JT, Hart L, Chu Q, Oza A, Tinker AV, Imedio ER, Kumar S, Mugundu G, Jenkins S, Chmielecki J, Jones S, Spigel D, Fu S
Target Oncol 2023 Jul;18(4):517-530. Epub 2023 Jun 6 doi: 10.1007/s11523-023-00965-7. PMID: 37278879Free PMC Article
Collagen XI alpha 1 chain, a potential therapeutic target for cancer.
Liu Z, Lai J, Jiang H, Ma C, Huang H
FASEB J 2021 Jun;35(6):e21603. doi: 10.1096/fj.202100054RR. PMID: 33999448
Ovarian pulmonary-type small cell carcinoma: case report and review of the literature.
Kurasaki A, Sakurai N, Yamamoto Y, Taoka H, Takahashi K, Kubushiro K
Int J Gynecol Pathol 2013 Sep;32(5):464-70. doi: 10.1097/PGP.0b013e31826d7ea8. PMID: 23896708
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Prognosis

Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.
Chen X, Liu HL, Wang JS, Zhao FH
Chin Med Sci J 2023 Jun 30;38(2):130-137. doi: 10.24920/004183. PMID: 37286512
Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

Clinical prediction guides

Efficacy and safety of autologous tumor-infiltrating lymphocytes in recurrent or refractory ovarian cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Amaria R, Knisely A, Vining D, Kopetz S, Overman MJ, Javle M, Antonoff MB, Tzeng CD, Wolff RA, Pant S, Lito K, Rangel K, Fellman B, Yuan Y, Lu KH, Sakellariou-Thompson D, Haymaker CL, Forget MA, Hwu P, Bernatchez C, Jazaeri AA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-006822. PMID: 38309721Free PMC Article
Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Spatial Mapping and Immunomodulatory Role of the OX40/OX40L Pathway in Human Non-Small Cell Lung Cancer.
Porciuncula A, Morgado M, Gupta R, Syrigos K, Meehan R, Zacharek SJ, Frederick JP, Schalper KA
Clin Cancer Res 2021 Nov 15;27(22):6174-6183. Epub 2021 Sep 13 doi: 10.1158/1078-0432.CCR-21-0987. PMID: 34518312Free PMC Article
Collagen XI alpha 1 chain, a potential therapeutic target for cancer.
Liu Z, Lai J, Jiang H, Ma C, Huang H
FASEB J 2021 Jun;35(6):e21603. doi: 10.1096/fj.202100054RR. PMID: 33999448
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

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