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del(17p13)

MedGen UID:
308331
•Concept ID:
C1515588
•
Cell or Molecular Dysfunction
Synonyms: -17p13; 17p13 Deletion; del(17)(p13)

Definition

A deletion of chromosomal material at 17p13. This chromosomal aberration includes deletion of the TP53 gene and is associated with multiple myeloma, chronic lymphocytic leukemia, acute myeloid leukemia and myelodysplastic syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVdel(17p13)

Professional guidelines

PubMed

Chronic lymphocytic leukemia with del(17p13.1): a distinct clinical subtype requiring novel treatment approaches.
Stephens DM, Byrd JC
Oncology (Williston Park) 2012 Nov;26(11):1044-54. PMID: 23330344
Update in the management of chronic lymphocytic leukemia.
Maddocks KJ, Lin TS
J Hematol Oncol 2009 Jul 20;2:29. doi: 10.1186/1756-8722-2-29. PMID: 19619273Free PMC Article
Flavopiridol in the treatment of chronic lymphocytic leukemia.
Christian BA, Grever MR, Byrd JC, Lin TS
Curr Opin Oncol 2007 Nov;19(6):573-8. doi: 10.1097/CCO.0b013e3282efb9da. PMID: 17906454

Recent clinical studies

Etiology

The histopathology of myeloma in the bone marrow.
Fujino M
J Clin Exp Hematop 2018;58(2):61-67. doi: 10.3960/jslrt.18014. PMID: 29998977Free PMC Article
Bruton tyrosine kinase inhibition in chronic lymphocytic leukemia.
Maddocks K, Jones JA
Semin Oncol 2016 Apr;43(2):251-9. Epub 2016 Feb 9 doi: 10.1053/j.seminoncol.2016.02.008. PMID: 27040703
New agents in chronic lymphocytic leukemia.
Lin TS
Curr Hematol Malig Rep 2010 Jan;5(1):29-34. doi: 10.1007/s11899-009-0039-9. PMID: 20425394
Flavopiridol in the treatment of chronic lymphocytic leukemia.
Christian BA, Grever MR, Byrd JC, Lin TS
Curr Opin Oncol 2007 Nov;19(6):573-8. doi: 10.1097/CCO.0b013e3282efb9da. PMID: 17906454
Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia.
Alinari L, Lapalombella R, Andritsos L, Baiocchi RA, Lin TS, Byrd JC
Oncogene 2007 May 28;26(25):3644-53. doi: 10.1038/sj.onc.1210380. PMID: 17530018

Diagnosis

Long intergenic non-coding RNA-p21 is associated with poor prognosis in chronic lymphocytic leukemia.
Abo Elwafa R, Abd Elrahman A, Ghallab O
Clin Transl Oncol 2021 Jan;23(1):92-99. Epub 2020 May 28 doi: 10.1007/s12094-020-02398-4. PMID: 32468342
The histopathology of myeloma in the bone marrow.
Fujino M
J Clin Exp Hematop 2018;58(2):61-67. doi: 10.3960/jslrt.18014. PMID: 29998977Free PMC Article
Chronic lymphocytic leukemia with del(17p13.1): a distinct clinical subtype requiring novel treatment approaches.
Stephens DM, Byrd JC
Oncology (Williston Park) 2012 Nov;26(11):1044-54. PMID: 23330344
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
The link between cytogenetics and mendelism.
Dallapiccola B, Mingarelli R, Novelli G
Biomed Pharmacother 1995;49(2):83-93. doi: 10.1016/0753-3322(96)82592-3. PMID: 7605907

Therapy

Venetoclax: Targeting BCL2 in Hematological Cancers.
Scheffold A, Jebaraj BMC, Stilgenbauer S
Recent Results Cancer Res 2018;212:215-242. doi: 10.1007/978-3-319-91439-8_11. PMID: 30069633
Bruton tyrosine kinase inhibition in chronic lymphocytic leukemia.
Maddocks K, Jones JA
Semin Oncol 2016 Apr;43(2):251-9. Epub 2016 Feb 9 doi: 10.1053/j.seminoncol.2016.02.008. PMID: 27040703
New agents in chronic lymphocytic leukemia.
Lin TS
Curr Hematol Malig Rep 2010 Jan;5(1):29-34. doi: 10.1007/s11899-009-0039-9. PMID: 20425394
Flavopiridol in the treatment of chronic lymphocytic leukemia.
Christian BA, Grever MR, Byrd JC, Lin TS
Curr Opin Oncol 2007 Nov;19(6):573-8. doi: 10.1097/CCO.0b013e3282efb9da. PMID: 17906454
Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia.
Alinari L, Lapalombella R, Andritsos L, Baiocchi RA, Lin TS, Byrd JC
Oncogene 2007 May 28;26(25):3644-53. doi: 10.1038/sj.onc.1210380. PMID: 17530018

Prognosis

Long intergenic non-coding RNA-p21 is associated with poor prognosis in chronic lymphocytic leukemia.
Abo Elwafa R, Abd Elrahman A, Ghallab O
Clin Transl Oncol 2021 Jan;23(1):92-99. Epub 2020 May 28 doi: 10.1007/s12094-020-02398-4. PMID: 32468342
Chronic lymphocytic leukemia with del(17p13.1): a distinct clinical subtype requiring novel treatment approaches.
Stephens DM, Byrd JC
Oncology (Williston Park) 2012 Nov;26(11):1044-54. PMID: 23330344
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone.
Klein U, Jauch A, Hielscher T, Hillengass J, Raab MS, Seckinger A, Hose D, Ho AD, Goldschmidt H, Neben K
Cancer 2011 May 15;117(10):2136-44. Epub 2010 Dec 4 doi: 10.1002/cncr.25775. PMID: 21523726
Intermediate prognosis of 6q deletion in chronic lymphocytic leukemia.
Wang DM, Miao KR, Fan L, Qiu HR, Fang C, Zhu DX, Qiu HX, Xu W, Li JY
Leuk Lymphoma 2011 Feb;52(2):230-7. doi: 10.3109/10428194.2010.542599. PMID: 21281237

Clinical prediction guides

Long intergenic non-coding RNA-p21 is associated with poor prognosis in chronic lymphocytic leukemia.
Abo Elwafa R, Abd Elrahman A, Ghallab O
Clin Transl Oncol 2021 Jan;23(1):92-99. Epub 2020 May 28 doi: 10.1007/s12094-020-02398-4. PMID: 32468342
Externally validated predictive clinical model for untreated del(17p13.1) chronic lymphocytic leukemia patients.
Stephens DM, Ruppert AS, Weirda WG, Jones JA, Woyach JA, Maddocks K, Jaglowski SM, Andritsos LA, Flynn JM, Grever MR, Lozanski G, Tam C, O'Brien S, Keating MJ, Muthusamy N, Abruzzo LV, Heerema NA, Byrd JC
Am J Hematol 2015 Nov;90(11):967-9. Epub 2015 Oct 12 doi: 10.1002/ajh.24125. PMID: 26202978Free PMC Article
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone.
Klein U, Jauch A, Hielscher T, Hillengass J, Raab MS, Seckinger A, Hose D, Ho AD, Goldschmidt H, Neben K
Cancer 2011 May 15;117(10):2136-44. Epub 2010 Dec 4 doi: 10.1002/cncr.25775. PMID: 21523726
Flavopiridol in chronic lymphocytic leukemia: a concise review.
Christian BA, Grever MR, Byrd JC, Lin TS
Clin Lymphoma Myeloma 2009;9 Suppl 3:S179-85. doi: 10.3816/CLM.2009.s.009. PMID: 19778838

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