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Postradiation Breast Angiosarcoma

MedGen UID:
307996
•Concept ID:
C1514246
•
Neoplastic Process
Synonyms: Post-Radiotherapy Breast Angiosarcoma; Postradiation Angiosarcoma of the Breast

Definition

A malignant vascular neoplasm arising from the skin of the breast secondary to radiation treatment for breast cancer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostradiation Breast Angiosarcoma

Professional guidelines

PubMed

The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast.
Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P, Hutchinson L
Hum Pathol 2015 Jun;46(6):868-75. Epub 2015 Mar 10 doi: 10.1016/j.humpath.2015.02.014. PMID: 25864386

Recent clinical studies

Etiology

Radiation-Associated Angiosarcoma of the Breast: Clinical and Pathologic Features.
Shah S, Rosa M
Arch Pathol Lab Med 2016 May;140(5):477-81. doi: 10.5858/arpa.2014-0581-RS. PMID: 27128306
Bilateral angiosarcoma of the breast after conservative treatment of bilateral invasive carcinoma: genetic predisposition?
de Bree E, van Coevorden F, Peterse JL, Russell NS, Rutgers EJ
Eur J Surg Oncol 2002 Jun;28(4):392-5. doi: 10.1053/ejso.2001.1249. PMID: 12099648

Diagnosis

Clinicopathologic and immunohistochemical study of breast angiosarcoma.
Yan M, Gilmore H, Bomeisl P, Harbhajanka A
Ann Diagn Pathol 2021 Oct;54:151795. Epub 2021 Jul 19 doi: 10.1016/j.anndiagpath.2021.151795. PMID: 34392127
MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast.
Sheu TG, Hunt KK, Middleton LP
Breast J 2021 Mar;27(3):264-267. Epub 2021 Feb 1 doi: 10.1111/tbj.14171. PMID: 33527629
Radiation-Associated Angiosarcoma of the Breast: Clinical and Pathologic Features.
Shah S, Rosa M
Arch Pathol Lab Med 2016 May;140(5):477-81. doi: 10.5858/arpa.2014-0581-RS. PMID: 27128306
Can c-myc amplification reliably discriminate postradiation from primary angiosarcoma of the breast?
Laé M, Lebel A, Hamel-Viard F, Asselain B, Trassard M, Sastre X, Kirova YM
Cancer Radiother 2015 May;19(3):168-74. Epub 2015 Apr 8 doi: 10.1016/j.canrad.2015.01.001. PMID: 25863565
Postradiation cutaneous angiosarcoma of the breast: a diagnosis to keep in mind.
Cabete J, Lencastre A, Fidalgo A, Lobo L, João A, Serrão V
Breast J 2014 Jan-Feb;20(1):89-90. Epub 2013 Nov 18 doi: 10.1111/tbj.12215. PMID: 24237660

Therapy

Early appearance of post-radiation angiosarcoma of the breast.
Mantilla N, Mashbari H, Abbed T, Acosta A, Emmadi R, Warso M
Breast J 2019 Mar;25(2):322-323. Epub 2019 Feb 6 doi: 10.1111/tbj.13217. PMID: 30727036
Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression.
Fraga-Guedes C, André S, Mastropasqua MG, Botteri E, Toesca A, Rocha RM, Peradze N, Rotmensz N, Viale G, Veronesi P, Gobbi H
Breast Cancer Res Treat 2015 May;151(1):131-40. Epub 2015 Apr 19 doi: 10.1007/s10549-015-3379-2. PMID: 25893585
Can c-myc amplification reliably discriminate postradiation from primary angiosarcoma of the breast?
Laé M, Lebel A, Hamel-Viard F, Asselain B, Trassard M, Sastre X, Kirova YM
Cancer Radiother 2015 May;19(3):168-74. Epub 2015 Apr 8 doi: 10.1016/j.canrad.2015.01.001. PMID: 25863565
Postradiation cutaneous angiosarcoma of the breast: a diagnosis to keep in mind.
Cabete J, Lencastre A, Fidalgo A, Lobo L, João A, Serrão V
Breast J 2014 Jan-Feb;20(1):89-90. Epub 2013 Nov 18 doi: 10.1111/tbj.12215. PMID: 24237660
Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 cases.
Billings SD, McKenney JK, Folpe AL, Hardacre MC, Weiss SW
Am J Surg Pathol 2004 Jun;28(6):781-8. doi: 10.1097/01.pas.0000126055.33916.0b. PMID: 15166670

Prognosis

MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast.
Sheu TG, Hunt KK, Middleton LP
Breast J 2021 Mar;27(3):264-267. Epub 2021 Feb 1 doi: 10.1111/tbj.14171. PMID: 33527629
Radiation-Associated Angiosarcoma of the Breast: Clinical and Pathologic Features.
Shah S, Rosa M
Arch Pathol Lab Med 2016 May;140(5):477-81. doi: 10.5858/arpa.2014-0581-RS. PMID: 27128306
Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression.
Fraga-Guedes C, André S, Mastropasqua MG, Botteri E, Toesca A, Rocha RM, Peradze N, Rotmensz N, Viale G, Veronesi P, Gobbi H
Breast Cancer Res Treat 2015 May;151(1):131-40. Epub 2015 Apr 19 doi: 10.1007/s10549-015-3379-2. PMID: 25893585
Bilateral angiosarcoma of the breast after conservative treatment of bilateral invasive carcinoma: genetic predisposition?
de Bree E, van Coevorden F, Peterse JL, Russell NS, Rutgers EJ
Eur J Surg Oncol 2002 Jun;28(4):392-5. doi: 10.1053/ejso.2001.1249. PMID: 12099648

Clinical prediction guides

Clinicopathologic and immunohistochemical study of breast angiosarcoma.
Yan M, Gilmore H, Bomeisl P, Harbhajanka A
Ann Diagn Pathol 2021 Oct;54:151795. Epub 2021 Jul 19 doi: 10.1016/j.anndiagpath.2021.151795. PMID: 34392127
Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer.
Kunkel T, Mylonas I, Mayr D, Friese K, Sommer HL
Arch Gynecol Obstet 2008 Nov;278(5):497-501. Epub 2008 Feb 28 doi: 10.1007/s00404-008-0605-8. PMID: 18305948

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