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DNA Interstrand Crosslinking

MedGen UID:
307395
•Concept ID:
C1511674
•
Cell or Molecular Dysfunction

Definition

DNA Interstrand Crosslinking involves the formation of a covalent bond between two bases on different DNA strand. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Interstrand Crosslinking

Professional guidelines

PubMed

Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.
Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DE, Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MA
Transl Res 2013 Mar;161(3):156-64. Epub 2012 Oct 11 doi: 10.1016/j.trsl.2012.09.003. PMID: 23063585Free PMC Article
Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy.
Wynne P, Newton C, Ledermann JA, Olaitan A, Mould TA, Hartley JA
Br J Cancer 2007 Oct 8;97(7):927-33. Epub 2007 Sep 11 doi: 10.1038/sj.bjc.6603973. PMID: 17848946Free PMC Article

Recent clinical studies

Etiology

A clickable psoralen to directly quantify DNA interstrand crosslinking and repair.
Evison BJ, Actis ML, Fujii N
Bioorg Med Chem 2016 Mar 1;24(5):1071-8. Epub 2016 Jan 18 doi: 10.1016/j.bmc.2016.01.032. PMID: 26833244Free PMC Article
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder.
Walden H, Deans AJ
Annu Rev Biophys 2014;43:257-78. doi: 10.1146/annurev-biophys-051013-022737. PMID: 24773018
XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids.
Feuerhahn S, Giraudon C, Martínez-Díez M, Bueren-Calabuig JA, Galmarini CM, Gago F, Egly JM
Chem Biol 2011 Aug 26;18(8):988-99. doi: 10.1016/j.chembiol.2011.06.007. PMID: 21867914
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA.
Ali AM, Singh TR, Meetei AR
Mutat Res 2009 Jul 31;668(1-2):20-6. Epub 2009 Apr 18 doi: 10.1016/j.mrfmmm.2009.04.002. PMID: 19379763Free PMC Article
The Fanconi anemia pathway limits the severity of mutagenesis.
Hinz JM, Nham PB, Salazar EP, Thompson LH
DNA Repair (Amst) 2006 Aug 13;5(8):875-84. Epub 2006 Jul 11 doi: 10.1016/j.dnarep.2006.05.039. PMID: 16815103

Diagnosis

BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents.
Zhu Z, Kitano T, Morimatsu M, Tanaka A, Morioka R, Lin X, Orino K, Yoshikawa Y
Int J Mol Sci 2022 Apr 6;23(7) doi: 10.3390/ijms23074060. PMID: 35409418Free PMC Article
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder.
Walden H, Deans AJ
Annu Rev Biophys 2014;43:257-78. doi: 10.1146/annurev-biophys-051013-022737. PMID: 24773018
DNA polymerase POLQ and cellular defense against DNA damage.
Yousefzadeh MJ, Wood RD
DNA Repair (Amst) 2013 Jan 1;12(1):1-9. Epub 2012 Dec 4 doi: 10.1016/j.dnarep.2012.10.004. PMID: 23219161Free PMC Article
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA.
Ali AM, Singh TR, Meetei AR
Mutat Res 2009 Jul 31;668(1-2):20-6. Epub 2009 Apr 18 doi: 10.1016/j.mrfmmm.2009.04.002. PMID: 19379763Free PMC Article
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
Richie CT, Peterson C, Lu T, Hittelman WN, Carpenter PB, Legerski RJ
Mol Cell Biol 2002 Dec;22(24):8635-47. doi: 10.1128/MCB.22.24.8635-8647.2002. PMID: 12446782Free PMC Article

Therapy

Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
Cho S, Zammarchi F, Williams DG, Havenith CEG, Monks NR, Tyrer P, D'Hooge F, Fleming R, Vashisht K, Dimasi N, Bertelli F, Corbett S, Adams L, Reinert HW, Dissanayake S, Britten CE, King W, Dacosta K, Tammali R, Schifferli K, Strout P, Korade M 3rd, Masson Hinrichs MJ, Chivers S, Corey E, Liu H, Kim S, Bander NH, Howard PW, Hartley JA, Coats S, Tice DA, Herbst R, van Berkel PH
Mol Cancer Ther 2018 Oct;17(10):2176-2186. Epub 2018 Jul 31 doi: 10.1158/1535-7163.MCT-17-0982. PMID: 30065100
Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort.
Chow EJ, Stratton KL, Leisenring WM, Oeffinger KC, Sklar CA, Donaldson SS, Ginsberg JP, Kenney LB, Levine JM, Robison LL, Shnorhavorian M, Stovall M, Armstrong GT, Green DM
Lancet Oncol 2016 May;17(5):567-76. Epub 2016 Mar 22 doi: 10.1016/S1470-2045(16)00086-3. PMID: 27020005Free PMC Article
Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.
Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DE, Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MA
Transl Res 2013 Mar;161(3):156-64. Epub 2012 Oct 11 doi: 10.1016/j.trsl.2012.09.003. PMID: 23063585Free PMC Article
Interstrand crosslink inducing agents in pretransplant conditioning therapy for hematologic malignancies.
Valdez BC, Andersson BS
Environ Mol Mutagen 2010 Jul;51(6):659-68. doi: 10.1002/em.20603. PMID: 20577993Free PMC Article
Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells.
Pepper C, Lowe H, Fegan C, Thurieau C, Thurston DE, Hartley JA, Delavault P
Br J Cancer 2007 Jul 16;97(2):253-9. Epub 2007 Jun 19 doi: 10.1038/sj.bjc.6603853. PMID: 17579621Free PMC Article

Prognosis

Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents.
Palagyi A, Neveling K, Plinninger U, Ziesch A, Targosz BS, Denk GU, Ochs S, Rizzani A, Meier D, Thasler WE, Hanenberg H, De Toni EN, Bassermann F, Schäfer C, Göke B, Schindler D, Gallmeier E
Mol Cancer 2010 May 28;9:127. doi: 10.1186/1476-4598-9-127. PMID: 20509860Free PMC Article
Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy.
Clingen PH, Wu JY, Miller J, Mistry N, Chin F, Wynne P, Prise KM, Hartley JA
Biochem Pharmacol 2008 Jul 1;76(1):19-27. Epub 2008 Apr 16 doi: 10.1016/j.bcp.2008.03.025. PMID: 18508035
The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino] benzoic acid.
Sunters A, Springer CJ, Bagshawe KD, Souhami RL, Hartley JA
Biochem Pharmacol 1992 Jul 7;44(1):59-64. doi: 10.1016/0006-2952(92)90038-k. PMID: 1632839
Effects of alkylating metabolites of ifosfamide and its bromo analogues on DNA of HeLa cells.
Studzian K, Kinas R, Ciesielska E, Szmigiero L
Biochem Pharmacol 1992 Mar 3;43(5):937-43. doi: 10.1016/0006-2952(92)90596-b. PMID: 1554391

Clinical prediction guides

The hSNM1B/Apollo variant rs11552449 is associated with cellular sensitivity towards mitomycin C and ionizing radiation.
Herwest S, Albers C, Schmiester M, Salewsky B, Hopfenmüller W, Meyer A, Bertram L, Demuth I
DNA Repair (Amst) 2018 Dec;72:93-98. Epub 2018 Sep 12 doi: 10.1016/j.dnarep.2018.09.004. PMID: 30262195
Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair.
Aoki Y, Sato A, Mizutani S, Takagi M
Int J Hematol 2014 Sep;100(3):260-5. Epub 2014 Jul 16 doi: 10.1007/s12185-014-1625-8. PMID: 25027282
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.
Thompson LH, Hinz JM
Mutat Res 2009 Jul 31;668(1-2):54-72. Epub 2009 Feb 21 doi: 10.1016/j.mrfmmm.2009.02.003. PMID: 19622404Free PMC Article
Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy.
Wynne P, Newton C, Ledermann JA, Olaitan A, Mould TA, Hartley JA
Br J Cancer 2007 Oct 8;97(7):927-33. Epub 2007 Sep 11 doi: 10.1038/sj.bjc.6603973. PMID: 17848946Free PMC Article
The Fanconi anemia pathway limits the severity of mutagenesis.
Hinz JM, Nham PB, Salazar EP, Thompson LH
DNA Repair (Amst) 2006 Aug 13;5(8):875-84. Epub 2006 Jul 11 doi: 10.1016/j.dnarep.2006.05.039. PMID: 16815103

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