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Bartholin gland squamous cell carcinoma

MedGen UID:
307249
•Concept ID:
C1511052
•
Neoplastic Process
Synonyms: Bartholin Gland Squamous Cell Carcinoma; bartholin gland squamous cell carcinoma; Bartholin's Gland Squamous Cell Carcinoma; Bartholin's gland squamous cell carcinoma; major vestibular gland squamous cell carcinoma
 
Monarch Initiative: MONDO:0004053

Definition

A carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant squamous epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBartholin gland squamous cell carcinoma

Professional guidelines

PubMed

Case series on the management and outcomes of Bartholin gland carcinoma.
Abdul-Aziz S, Jayraj AS, Adusumalli M, Rajan Babu A
Eur J Obstet Gynecol Reprod Biol 2024 Aug;299:26-31. Epub 2024 May 23 doi: 10.1016/j.ejogrb.2024.05.028. PMID: 38824810
Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Management of primary and recurrent Bartholin's gland carcinoma: A systematic review on behalf of MITO Rare Cancer Group.
Turetta C, Mazzeo R, Capalbo G, Miano S, Fruscio R, Di Donato V, Falcone F, Mangili G, Pignata S, Palaia I
Tumori 2024 Apr;110(2):96-108. Epub 2023 Nov 13 doi: 10.1177/03008916231208308. PMID: 37953636

Recent clinical studies

Etiology

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Management of primary and recurrent Bartholin's gland carcinoma: A systematic review on behalf of MITO Rare Cancer Group.
Turetta C, Mazzeo R, Capalbo G, Miano S, Fruscio R, Di Donato V, Falcone F, Mangili G, Pignata S, Palaia I
Tumori 2024 Apr;110(2):96-108. Epub 2023 Nov 13 doi: 10.1177/03008916231208308. PMID: 37953636
Bartholin Gland Carcinoma: Clinicopathologic Features, Including p16 Expression and Clinical Outcome.
Nazeran T, Cheng AS, Karnezis AN, Tinker AV, Gilks CB
Int J Gynecol Pathol 2019 Mar;38(2):189-195. doi: 10.1097/PGP.0000000000000489. PMID: 29406447
Carcinoma of the Bartholin Gland: A Review of 33 Cases.
Bhalwal AB, Nick AM, Dos Reis R, Chen CL, Munsell MF, Ramalingam P, Salcedo MP, Ramirez PT, Sood AK, Schmeler KM
Int J Gynecol Cancer 2016 May;26(4):785-9. doi: 10.1097/IGC.0000000000000656. PMID: 26844611Free PMC Article
Bartholin's gland carcinoma, malignant melanoma and other rare tumours of the vulva.
Finan MA, Barre G
Best Pract Res Clin Obstet Gynaecol 2003 Aug;17(4):609-33. doi: 10.1016/s1521-6934(03)00039-7. PMID: 12965135

Diagnosis

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Carcinoma of the Bartholin Gland: A Review of 33 Cases.
Bhalwal AB, Nick AM, Dos Reis R, Chen CL, Munsell MF, Ramalingam P, Salcedo MP, Ramirez PT, Sood AK, Schmeler KM
Int J Gynecol Cancer 2016 May;26(4):785-9. doi: 10.1097/IGC.0000000000000656. PMID: 26844611Free PMC Article
Carcinomas and sarcomas of Bartholin gland. A report of nine cases and review of the literature.
Kozakiewicz B, Dmoch-Gajzlerska E, Roszkowska-Purska K
Eur J Gynaecol Oncol 2014;35(3):243-9. PMID: 24984535
Bartholin gland carcinoma.
Copeland LJ, Sneige N, Gershenson DM, McGuffee VB, Abdul-Karim F, Rutledge FN
Obstet Gynecol 1986 Jun;67(6):794-801. doi: 10.1097/00006250-198606000-00009. PMID: 3010205
The vestibule.
Woodruff JD, Friedrich EG Jr
Clin Obstet Gynecol 1985 Mar;28(1):134-41. doi: 10.1097/00003081-198528010-00016. PMID: 3987127

Therapy

Carcinoma of the Bartholin Gland: A Review of 33 Cases.
Bhalwal AB, Nick AM, Dos Reis R, Chen CL, Munsell MF, Ramalingam P, Salcedo MP, Ramirez PT, Sood AK, Schmeler KM
Int J Gynecol Cancer 2016 May;26(4):785-9. doi: 10.1097/IGC.0000000000000656. PMID: 26844611Free PMC Article
Primary vulvar Ewing's sarcoma/primitive neuroectodermal tumor in a post-menopausal woman: a case report.
Boldorini R, Riboni F, Cristina S, Allegrini S, Valentini S, Muscarà M, Ruspa G
Pathol Res Pract 2010 Jul 15;206(7):476-9. Epub 2009 Aug 4 doi: 10.1016/j.prp.2009.07.006. PMID: 19656640
Advanced primary carcinoma of the Bartholin gland: report of 18 patients.
Balat O, Edwards CL, Delclos L
Eur J Gynaecol Oncol 2001;22(1):46-9. PMID: 11321493
Hyperbaric oxygen therapy following radical vulvectomy: an adjunctive therapy to improve wound healing.
Reedy MB, Capen CV, Baker DP, Petersen WG, Kuehl TJ
Gynecol Oncol 1994 Apr;53(1):13-6. doi: 10.1006/gyno.1994.1079. PMID: 8175014
Role of radiation therapy in the treatment of advanced vulvar carcinoma.
Miyazawa K, Nori D, Hilaris BS, Lewis JL Jr
J Reprod Med 1983 Aug;28(8):539-41. PMID: 6415281

Prognosis

Vulvar Adenoid Cystic Carcinoma with Squamous Cell Carcinoma Component.
Han A, Kato S, Morinaga K, Izumi M, Kiyokawa K
Kurume Med J 2024 May 14;69(3.4):251-254. Epub 2024 Jan 16 doi: 10.2739/kurumemedj.MS6934004. PMID: 38233185
Bartholin gland cancer.
Di Donato V, Casorelli A, Bardhi E, Vena F, Marchetti C, Muzii L, Benedetti Panici P
Crit Rev Oncol Hematol 2017 Sep;117:1-11. Epub 2017 Jun 13 doi: 10.1016/j.critrevonc.2017.06.005. PMID: 28807231
Carcinoma of the Bartholin Gland: A Review of 33 Cases.
Bhalwal AB, Nick AM, Dos Reis R, Chen CL, Munsell MF, Ramalingam P, Salcedo MP, Ramirez PT, Sood AK, Schmeler KM
Int J Gynecol Cancer 2016 May;26(4):785-9. doi: 10.1097/IGC.0000000000000656. PMID: 26844611Free PMC Article
Carcinomas and sarcomas of Bartholin gland. A report of nine cases and review of the literature.
Kozakiewicz B, Dmoch-Gajzlerska E, Roszkowska-Purska K
Eur J Gynaecol Oncol 2014;35(3):243-9. PMID: 24984535
Bartholin's gland carcinoma, malignant melanoma and other rare tumours of the vulva.
Finan MA, Barre G
Best Pract Res Clin Obstet Gynaecol 2003 Aug;17(4):609-33. doi: 10.1016/s1521-6934(03)00039-7. PMID: 12965135

Clinical prediction guides

Bartholin Gland Carcinoma: Clinicopathologic Features, Including p16 Expression and Clinical Outcome.
Nazeran T, Cheng AS, Karnezis AN, Tinker AV, Gilks CB
Int J Gynecol Pathol 2019 Mar;38(2):189-195. doi: 10.1097/PGP.0000000000000489. PMID: 29406447
Carcinomas and sarcomas of Bartholin gland. A report of nine cases and review of the literature.
Kozakiewicz B, Dmoch-Gajzlerska E, Roszkowska-Purska K
Eur J Gynaecol Oncol 2014;35(3):243-9. PMID: 24984535
Contralateral groin recurrence in patients with stage I Bartholin's gland squamous cell carcinoma and negative ipsilateral nodes: report on two cases and implications for lymphadenectomy.
Mazouni C, Morice P, Duvillard P, Bonnier P, Castaigne D
Gynecol Oncol 2004 Sep;94(3):843-5. doi: 10.1016/j.ygyno.2004.05.051. PMID: 15350386
Advanced primary carcinoma of the Bartholin gland: report of 18 patients.
Balat O, Edwards CL, Delclos L
Eur J Gynaecol Oncol 2001;22(1):46-9. PMID: 11321493
Hyperbaric oxygen therapy following radical vulvectomy: an adjunctive therapy to improve wound healing.
Reedy MB, Capen CV, Baker DP, Petersen WG, Kuehl TJ
Gynecol Oncol 1994 Apr;53(1):13-6. doi: 10.1006/gyno.1994.1079. PMID: 8175014

Recent systematic reviews

Management of primary and recurrent Bartholin's gland carcinoma: A systematic review on behalf of MITO Rare Cancer Group.
Turetta C, Mazzeo R, Capalbo G, Miano S, Fruscio R, Di Donato V, Falcone F, Mangili G, Pignata S, Palaia I
Tumori 2024 Apr;110(2):96-108. Epub 2023 Nov 13 doi: 10.1177/03008916231208308. PMID: 37953636

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