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Pharyngeal Anastomotic Leakage

MedGen UID:
305588
•Concept ID:
C1696702
•
Pathologic Function

Definition

Leakage due to breakdown of a pharyngeal anastomosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPharyngeal Anastomotic Leakage

Recent clinical studies

Etiology

Factors Associated with Complications after Total Pharyngo-Laryngo-Esophagectomy and Free Jejunal Flap Reconstruction.
Ikuta K, Suyama Y, Fukuoka K, Morita M, Kimura Y, Umeda R, Kanayama H, Ohga M, Nakagaki M, Fukuhara T, Fujiwara K, Yagi S
ORL J Otorhinolaryngol Relat Spec 2023;85(5):275-283. Epub 2023 Jun 7 doi: 10.1159/000530920. PMID: 37285823
Surgical Management of Post-Esophagectomy Tracheo-Bronchial-Esophageal Fistula.
Balakrishnan A, Tapias L, Wright CD, Lanuti MX, Gaissert HA, Mathisen DJ, Muniappan A
Ann Thorac Surg 2018 Dec;106(6):1640-1646. Epub 2018 Aug 29 doi: 10.1016/j.athoracsur.2018.06.076. PMID: 30171850
Early prediction of anastomotic leakage after free jejunal flap reconstruction of circumferential pharyngeal defects.
Chan JY, Liu LH, Wei WI
J Plast Reconstr Aesthet Surg 2013 Mar;66(3):376-81. Epub 2012 Oct 25 doi: 10.1016/j.bjps.2012.09.035. PMID: 23102872
Should oesophagectomy be performed with cervical or intrathoracic anastomosis?
Kayani B, Jarral OA, Athanasiou T, Zacharakis E
Interact Cardiovasc Thorac Surg 2012 Jun;14(6):821-6. Epub 2012 Feb 24 doi: 10.1093/icvts/ivs036. PMID: 22368108Free PMC Article
Reducing hospital morbidity and mortality following esophagectomy.
Atkins BZ, Shah AS, Hutcheson KA, Mangum JH, Pappas TN, Harpole DH Jr, D'Amico TA
Ann Thorac Surg 2004 Oct;78(4):1170-6; discussion 1170-6. doi: 10.1016/j.athoracsur.2004.02.034. PMID: 15464465

Diagnosis

Outcome Analysis Of Total Laryngopharyngeal Oesophagectomy In Carcinoma Hypo-Pharynx And Cervical Esophagus, With Stomach Reconstruction.
Majeed FA, Aslam S, Farooq S, Ali A, Raza A, Zafar U
J Ayub Med Coll Abbottabad 2020 Jan-Mar;32(1):13-17. PMID: 32468747
The evaluation of deglutition with videofluoroscopy after repair of esophageal atresia and/or tracheoesophageal fistula.
Yalcin S, Demir N, Serel S, Soyer T, Tanyel FC
J Pediatr Surg 2015 Nov;50(11):1823-7. Epub 2015 Jul 3 doi: 10.1016/j.jpedsurg.2015.07.002. PMID: 26210818
Early prediction of anastomotic leakage after free jejunal flap reconstruction of circumferential pharyngeal defects.
Chan JY, Liu LH, Wei WI
J Plast Reconstr Aesthet Surg 2013 Mar;66(3):376-81. Epub 2012 Oct 25 doi: 10.1016/j.bjps.2012.09.035. PMID: 23102872
Free jejunal graft for esophageal reconstruction using end-to-side vascular anastomosis and extended pharyngo-jejunostomy.
Lee HS, Park SY, Jang HJ, Kim MS, Lee JM, Zo JI
Ann Thorac Surg 2012 Jun;93(6):1850-4. Epub 2012 Mar 20 doi: 10.1016/j.athoracsur.2012.01.068. PMID: 22440367
The prognostic value of abnormal findings on radiographic swallowing studies after total laryngectomy.
van la Parra RF, Kon M, Schellekens PP, Braunius WW, Pameijer FA
Cancer Imaging 2007 Jun 11;7(1):119-25. doi: 10.1102/1470-7330.2007.0015. PMID: 17562591Free PMC Article

Therapy

Factors Associated with Complications after Total Pharyngo-Laryngo-Esophagectomy and Free Jejunal Flap Reconstruction.
Ikuta K, Suyama Y, Fukuoka K, Morita M, Kimura Y, Umeda R, Kanayama H, Ohga M, Nakagaki M, Fukuhara T, Fujiwara K, Yagi S
ORL J Otorhinolaryngol Relat Spec 2023;85(5):275-283. Epub 2023 Jun 7 doi: 10.1159/000530920. PMID: 37285823
Systematic Review and Meta-analysis of SurgicalTreatment of Non-Zenker's Oesophageal Diverticula.
Chan DSY, Foliaki A, Lewis WG, Clark GWB, Blackshaw GRJC
J Gastrointest Surg 2017 Jun;21(6):1067-1075. Epub 2017 Jan 20 doi: 10.1007/s11605-017-3368-3. PMID: 28108931Free PMC Article
Early prediction of anastomotic leakage after free jejunal flap reconstruction of circumferential pharyngeal defects.
Chan JY, Liu LH, Wei WI
J Plast Reconstr Aesthet Surg 2013 Mar;66(3):376-81. Epub 2012 Oct 25 doi: 10.1016/j.bjps.2012.09.035. PMID: 23102872
Should oesophagectomy be performed with cervical or intrathoracic anastomosis?
Kayani B, Jarral OA, Athanasiou T, Zacharakis E
Interact Cardiovasc Thorac Surg 2012 Jun;14(6):821-6. Epub 2012 Feb 24 doi: 10.1093/icvts/ivs036. PMID: 22368108Free PMC Article
Intestinal bypass of the esophagus.
Raffensperger JG, Luck SR, Reynolds M, Schwartz D
J Pediatr Surg 1996 Jan;31(1):38-46; discussion 46-7. doi: 10.1016/s0022-3468(96)90316-4. PMID: 8632284

Prognosis

Early prediction of anastomotic leakage after free jejunal flap reconstruction of circumferential pharyngeal defects.
Chan JY, Liu LH, Wei WI
J Plast Reconstr Aesthet Surg 2013 Mar;66(3):376-81. Epub 2012 Oct 25 doi: 10.1016/j.bjps.2012.09.035. PMID: 23102872
Should oesophagectomy be performed with cervical or intrathoracic anastomosis?
Kayani B, Jarral OA, Athanasiou T, Zacharakis E
Interact Cardiovasc Thorac Surg 2012 Jun;14(6):821-6. Epub 2012 Feb 24 doi: 10.1093/icvts/ivs036. PMID: 22368108Free PMC Article
Reducing hospital morbidity and mortality following esophagectomy.
Atkins BZ, Shah AS, Hutcheson KA, Mangum JH, Pappas TN, Harpole DH Jr, D'Amico TA
Ann Thorac Surg 2004 Oct;78(4):1170-6; discussion 1170-6. doi: 10.1016/j.athoracsur.2004.02.034. PMID: 15464465
Intestinal bypass of the esophagus.
Raffensperger JG, Luck SR, Reynolds M, Schwartz D
J Pediatr Surg 1996 Jan;31(1):38-46; discussion 46-7. doi: 10.1016/s0022-3468(96)90316-4. PMID: 8632284
Esophagectomy without thoracotomy.
Orringer MB, Sloan H
J Thorac Cardiovasc Surg 1978 Nov;76(5):643-54. PMID: 703369

Clinical prediction guides

Factors Associated with Complications after Total Pharyngo-Laryngo-Esophagectomy and Free Jejunal Flap Reconstruction.
Ikuta K, Suyama Y, Fukuoka K, Morita M, Kimura Y, Umeda R, Kanayama H, Ohga M, Nakagaki M, Fukuhara T, Fujiwara K, Yagi S
ORL J Otorhinolaryngol Relat Spec 2023;85(5):275-283. Epub 2023 Jun 7 doi: 10.1159/000530920. PMID: 37285823
Systematic Review and Meta-analysis of SurgicalTreatment of Non-Zenker's Oesophageal Diverticula.
Chan DSY, Foliaki A, Lewis WG, Clark GWB, Blackshaw GRJC
J Gastrointest Surg 2017 Jun;21(6):1067-1075. Epub 2017 Jan 20 doi: 10.1007/s11605-017-3368-3. PMID: 28108931Free PMC Article
The use of low-osmolar water-soluble contrast in videofluoroscopic swallowing exams.
Harris JA, Bartelt D, Campion M, Gayler BW, Jones B, Hayes A, Haynos J, Herbick S, Kling T, Lingaraj A, Singer M, Starmer H, Smith C, Webster K
Dysphagia 2013 Dec;28(4):520-7. Epub 2013 Mar 26 doi: 10.1007/s00455-013-9462-0. PMID: 23529533
Early prediction of anastomotic leakage after free jejunal flap reconstruction of circumferential pharyngeal defects.
Chan JY, Liu LH, Wei WI
J Plast Reconstr Aesthet Surg 2013 Mar;66(3):376-81. Epub 2012 Oct 25 doi: 10.1016/j.bjps.2012.09.035. PMID: 23102872
Reducing hospital morbidity and mortality following esophagectomy.
Atkins BZ, Shah AS, Hutcheson KA, Mangum JH, Pappas TN, Harpole DH Jr, D'Amico TA
Ann Thorac Surg 2004 Oct;78(4):1170-6; discussion 1170-6. doi: 10.1016/j.athoracsur.2004.02.034. PMID: 15464465

Recent systematic reviews

Systematic Review and Meta-analysis of SurgicalTreatment of Non-Zenker's Oesophageal Diverticula.
Chan DSY, Foliaki A, Lewis WG, Clark GWB, Blackshaw GRJC
J Gastrointest Surg 2017 Jun;21(6):1067-1075. Epub 2017 Jan 20 doi: 10.1007/s11605-017-3368-3. PMID: 28108931Free PMC Article

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