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Carbuncle

MedGen UID:
2866
•Concept ID:
C0007078
•
Disease or Syndrome
Synonym: Carbuncles
SNOMED CT: Carbuncle (416893007); Carbuncle (41570003)
 
HPO: HP:0020084
Monarch Initiative: MONDO:0002237

Definition

A pustular lesion of the skin emerging from group of infected hair follicles, characterized by a deep location and dissecting through tissue planes. A carbuncle is larger and deeper than a furuncle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarbuncle

Professional guidelines

PubMed

Mapping the evidence about the natural history of acute infections commonly seen in primary care and managed with antibiotics: a scoping review.
Boaitey KP, Bakhit M, Hoffmann TC
BMC Infect Dis 2024 Jul 23;24(1):721. doi: 10.1186/s12879-024-09526-3. PMID: 39044144Free PMC Article
Etiology, clinical features, management, and outcomes of skin and soft tissue infections in hospitalized children: A 10-year review.
Yueh CM, Chi H, Chiu NC, Huang FY, Tsung-Ning Huang D, Chang L, Kung YH, Huang CY
J Microbiol Immunol Infect 2022 Aug;55(4):728-739. Epub 2022 Mar 3 doi: 10.1016/j.jmii.2022.01.007. PMID: 35283045
Right siting of complex acute wound management---preliminary study of teleconsultation wound services between acute and primary care in Singapore.
Chang YY, Ang SY, Ong CE, Peng SS, Zulkifli H, Hashim N, Yeo GH, Goh WT, Liew AYJ, Tan WX, Lee JH, Aloweni F
J Tissue Viability 2022 May;31(2):353-357. Epub 2021 Oct 1 doi: 10.1016/j.jtv.2021.09.006. PMID: 34711417

Recent clinical studies

Etiology

Dahuang Mudan decoction repairs intestinal barrier in chronic colitic mice by regulating the function of ILC3.
Huang S, Wang X, Xie X, Su Y, Pan Z, Li Y, Liang J, Zhang M, Pan S, Xu B, Li L, Chen J, Luo X, Zhou L
J Ethnopharmacol 2022 Dec 5;299:115652. Epub 2022 Aug 28 doi: 10.1016/j.jep.2022.115652. PMID: 36038092
Etiology, clinical features, management, and outcomes of skin and soft tissue infections in hospitalized children: A 10-year review.
Yueh CM, Chi H, Chiu NC, Huang FY, Tsung-Ning Huang D, Chang L, Kung YH, Huang CY
J Microbiol Immunol Infect 2022 Aug;55(4):728-739. Epub 2022 Mar 3 doi: 10.1016/j.jmii.2022.01.007. PMID: 35283045
Interventions for bacterial folliculitis and boils (furuncles and carbuncles).
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Skin and soft tissue infection.
Sharma S, Verma KK
Indian J Pediatr 2001 Jul;68 Suppl 3:S46-50. PMID: 11980459
Dermatological problems in the athlete.
Eiland G, Ridley D
J Orthop Sports Phys Ther 1996 Jun;23(6):388-402. doi: 10.2519/jospt.1996.23.6.388. PMID: 8727020

Diagnosis

Common Skin Conditions in Children and Adolescents: Bacterial Infections.
Zha M, Usatine R
FP Essent 2024 Jun;541:14-19. PMID: 38896826
Interventions for bacterial folliculitis and boils (furuncles and carbuncles).
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Severe bacterial skin infections.
Marques SA, Abbade LPF
An Bras Dermatol 2020 Jul-Aug;95(4):407-417. Epub 2020 May 16 doi: 10.1016/j.abd.2020.04.003. PMID: 32507327Free PMC Article
Common bacterial skin infections.
Trent JT, Federman D, Kirsner RS
Ostomy Wound Manage 2001 Aug;47(8):30-4. PMID: 11890001
Renal carbuncles.
Br Med J 1978 May 6;1(6121):1166-7. PMID: 638674Free PMC Article

Therapy

Dahuang Mudan decoction repairs intestinal barrier in chronic colitic mice by regulating the function of ILC3.
Huang S, Wang X, Xie X, Su Y, Pan Z, Li Y, Liang J, Zhang M, Pan S, Xu B, Li L, Chen J, Luo X, Zhou L
J Ethnopharmacol 2022 Dec 5;299:115652. Epub 2022 Aug 28 doi: 10.1016/j.jep.2022.115652. PMID: 36038092
Interventions for bacterial folliculitis and boils (furuncles and carbuncles).
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents.
Jiang M, Sheng F, Zhang Z, Ma X, Gao T, Fu C, Li P
J Ethnopharmacol 2021 May 23;272:113954. Epub 2021 Feb 18 doi: 10.1016/j.jep.2021.113954. PMID: 33610706
The chemistry and pharmacology of Ligularia przewalskii: A review.
Liu SJ, Tang ZS, Liao ZX, Cui CL, Liu HB, Liang YN, Zhang Y, Xu HB, Zhang DB, Zheng YT, Shi HX, Li SY
J Ethnopharmacol 2018 Jun 12;219:32-49. Epub 2018 Mar 8 doi: 10.1016/j.jep.2018.03.002. PMID: 29526703
Gleditsia species: An ethnomedical, phytochemical and pharmacological review.
Zhang JP, Tian XH, Yang YX, Liu QX, Wang Q, Chen LP, Li HL, Zhang WD
J Ethnopharmacol 2016 Feb 3;178:155-71. Epub 2015 Nov 28 doi: 10.1016/j.jep.2015.11.044. PMID: 26643065

Prognosis

Mapping the evidence about the natural history of acute infections commonly seen in primary care and managed with antibiotics: a scoping review.
Boaitey KP, Bakhit M, Hoffmann TC
BMC Infect Dis 2024 Jul 23;24(1):721. doi: 10.1186/s12879-024-09526-3. PMID: 39044144Free PMC Article
Etiology, clinical features, management, and outcomes of skin and soft tissue infections in hospitalized children: A 10-year review.
Yueh CM, Chi H, Chiu NC, Huang FY, Tsung-Ning Huang D, Chang L, Kung YH, Huang CY
J Microbiol Immunol Infect 2022 Aug;55(4):728-739. Epub 2022 Mar 3 doi: 10.1016/j.jmii.2022.01.007. PMID: 35283045
Skin and soft tissue infections, active component, U.S. Armed Forces, January 2016-September 2020.
Stahlman S, Williams VF, Oh GT, Tribble DR, Millar EV
MSMR 2021 Apr;28(4):27-38. PMID: 33975438
Integrated strategy of LC-MS and network pharmacology for predicting active constituents and pharmacological mechanisms of Ranunculus japonicus Thunb. for treating rheumatoid arthritis.
Wang ZY, Chu FH, Gu NN, Wang Y, Feng D, Zhao X, Meng XD, Zhang WT, Li CF, Chen Y, Wei SS, Ma ZQ, Lin RC, Zhao CJ, Zou DX
J Ethnopharmacol 2021 May 10;271:113818. Epub 2021 Jan 16 doi: 10.1016/j.jep.2021.113818. PMID: 33465444
Skin and soft tissue infections, active component, U.S. Armed Forces, 2013-2016.
Stahlman S, Williams VF, Oh GT, Millar EV, Bennett JW
MSMR 2017 Jul;24(7):2-11. PMID: 28731725

Clinical prediction guides

Efficacy and Adverse Reactions of Dahuang Mudan decoction Combined with Laparoscopy in the Treatment of Appendicitis: A Meta-Analysis.
Cong S, Wu G, Jin Y, Zhu L
Altern Ther Health Med 2023 Nov;29(8):822-829. PMID: 37773648
The causal relationship between obesity and skin and soft tissue infections: A two-sample Mendelian randomization study.
Hu H, Mei J, Lin M, Wu X, Lin H, Chen G
Front Endocrinol (Lausanne) 2022;13:996863. Epub 2022 Dec 7 doi: 10.3389/fendo.2022.996863. PMID: 36568121Free PMC Article
Dahuang Mudan decoction repairs intestinal barrier in chronic colitic mice by regulating the function of ILC3.
Huang S, Wang X, Xie X, Su Y, Pan Z, Li Y, Liang J, Zhang M, Pan S, Xu B, Li L, Chen J, Luo X, Zhou L
J Ethnopharmacol 2022 Dec 5;299:115652. Epub 2022 Aug 28 doi: 10.1016/j.jep.2022.115652. PMID: 36038092
Study of Infections in Type 2 Diabetes Mellitus.
Nikitha N, Satpathy PK
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443370
Etiology, clinical features, management, and outcomes of skin and soft tissue infections in hospitalized children: A 10-year review.
Yueh CM, Chi H, Chiu NC, Huang FY, Tsung-Ning Huang D, Chang L, Kung YH, Huang CY
J Microbiol Immunol Infect 2022 Aug;55(4):728-739. Epub 2022 Mar 3 doi: 10.1016/j.jmii.2022.01.007. PMID: 35283045

Recent systematic reviews

Recent research progress of Cirsium medicinal plants in China.
Luo W, Wu B, Tang L, Li G, Chen H, Yin X
J Ethnopharmacol 2021 Nov 15;280:114475. Epub 2021 Aug 4 doi: 10.1016/j.jep.2021.114475. PMID: 34363929
Interventions for bacterial folliculitis and boils (furuncles and carbuncles).
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article

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