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Occult Lung Non-Small Cell Carcinoma

MedGen UID:
277444
•Concept ID:
C1335098
•
Neoplastic Process
Synonyms: Occult Non-Small Cell Carcinoma of Lung; Occult Non-Small Cell Carcinoma of the Lung; Occult Non-Small Cell Lung Carcinoma

Definition

A non-small cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOccult Lung Non-Small Cell Carcinoma

Professional guidelines

PubMed

Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720
Intratumoural chemotherapy of lung cancer for diagnosis and treatment of draining lymph node metastasis.
Celikoglu F, Celikoglu SI, Goldberg EP
J Pharm Pharmacol 2010 Mar;62(3):287-95. doi: 10.1211/jpp.62.03.0001. PMID: 20487210
Follow-up and surveillance of the lung cancer patient following curative-intent therapy.
Colice GL, Rubins J, Unger M; American College of Chest Physicians
Chest 2003 Jan;123(1 Suppl):272S-283S. doi: 10.1378/chest.123.1_suppl.272s. PMID: 12527585

Recent clinical studies

Etiology

Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.
Steinfort DP, Kothari G, Wallace N, Hardcastle N, Rangamuwa K, Dieleman EMT, Lee P, Li P, Simpson JA, Yo S, Bashirdazeh F, Nguyen P, Jennings BR, Fielding D, Crombag L, Irving LB, Yasufuku K, Annema JT, Ost DE, Siva S
Lancet Respir Med 2024 Jun;12(6):467-475. Epub 2024 Mar 12 doi: 10.1016/S2213-2600(24)00010-9. PMID: 38490228
PET/CT based cross-modal deep learning signature to predict occult nodal metastasis in lung cancer.
Zhong Y, Cai C, Chen T, Gui H, Deng J, Yang M, Yu B, Song Y, Wang T, Sun X, Shi J, Chen Y, Xie D, Chen C, She Y
Nat Commun 2023 Nov 18;14(1):7513. doi: 10.1038/s41467-023-42811-4. PMID: 37980411Free PMC Article
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Mandatory Nodal Evaluation During Resection of Clinical T1a Non-Small Cell Lung Cancers.
Dezube AR, Mazzola E, Deeb A, Wiener DC, Marshall MB, Rochefort MW, Jaklitsch MT
Ann Thorac Surg 2022 May;113(5):1583-1590. Epub 2021 Aug 3 doi: 10.1016/j.athoracsur.2021.06.078. PMID: 34358520
Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720

Diagnosis

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Oligometastasis: Past, Present, Future.
Gutiontov SI, Pitroda SP, Weichselbaum RR
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):530-538. doi: 10.1016/j.ijrobp.2020.02.019. PMID: 32976785
Mediastinal Staging in Non-Small Cell Lung Cancer.
Gamliel Z
Surg Oncol Clin N Am 2016 Jul;25(3):493-502. doi: 10.1016/j.soc.2016.02.004. PMID: 27261911
The ectopic ACTH syndrome.
Alexandraki KI, Grossman AB
Rev Endocr Metab Disord 2010 Jun;11(2):117-26. doi: 10.1007/s11154-010-9139-z. PMID: 20544290
Therapeutic sentinel lymph node imaging.
Kachala SS, Servais EL, Park BJ, Rusch VW, Adusumilli PS
Semin Thorac Cardiovasc Surg 2009 Winter;21(4):327-38. doi: 10.1053/j.semtcvs.2009.11.002. PMID: 20226346

Therapy

Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.
Steinfort DP, Kothari G, Wallace N, Hardcastle N, Rangamuwa K, Dieleman EMT, Lee P, Li P, Simpson JA, Yo S, Bashirdazeh F, Nguyen P, Jennings BR, Fielding D, Crombag L, Irving LB, Yasufuku K, Annema JT, Ost DE, Siva S
Lancet Respir Med 2024 Jun;12(6):467-475. Epub 2024 Mar 12 doi: 10.1016/S2213-2600(24)00010-9. PMID: 38490228
Oligometastasis: Past, Present, Future.
Gutiontov SI, Pitroda SP, Weichselbaum RR
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):530-538. doi: 10.1016/j.ijrobp.2020.02.019. PMID: 32976785
18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of clinically node-negative non-small cell lung cancer.
Takahashi Y, Suzuki S, Matsutani N, Kawamura M
Thorac Cancer 2019 Mar;10(3):413-420. Epub 2019 Jan 21 doi: 10.1111/1759-7714.12978. PMID: 30666803Free PMC Article
Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720
Tumors of unknown origin.
Greco FA, Hainsworth JD
CA Cancer J Clin 1992 Mar-Apr;42(2):96-115. doi: 10.3322/canjclin.42.2.96. PMID: 1540854

Prognosis

PET/CT based cross-modal deep learning signature to predict occult nodal metastasis in lung cancer.
Zhong Y, Cai C, Chen T, Gui H, Deng J, Yang M, Yu B, Song Y, Wang T, Sun X, Shi J, Chen Y, Xie D, Chen C, She Y
Nat Commun 2023 Nov 18;14(1):7513. doi: 10.1038/s41467-023-42811-4. PMID: 37980411Free PMC Article
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Oligometastasis: Past, Present, Future.
Gutiontov SI, Pitroda SP, Weichselbaum RR
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):530-538. doi: 10.1016/j.ijrobp.2020.02.019. PMID: 32976785
Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720
The ectopic ACTH syndrome.
Alexandraki KI, Grossman AB
Rev Endocr Metab Disord 2010 Jun;11(2):117-26. doi: 10.1007/s11154-010-9139-z. PMID: 20544290

Clinical prediction guides

Outcomes of Patients Undergoing Segmentectomy for Occult Node-Positive Clinical Stage IA Lung Cancer.
Nobel TB, Tan KS, Adusumilli PS, Bains MS, Downey RJ, Gray K, Huang J, Isbell JM, Molena D, Park BJ, Rocco G, Rusch VW, Sihag S, Jones DR, Bott MJ
Ann Thorac Surg 2024 Sep;118(3):655-663. Epub 2024 Jun 10 doi: 10.1016/j.athoracsur.2024.05.031. PMID: 38866198Free PMC Article
Computed tomography characteristics of cN0 primary non-small cell lung cancer predict occult lymph node metastasis.
Yoon DW, Kang D, Jeon YJ, Lee J, Shin S, Cho JH, Choi YS, Zo JI, Kim J, Shim YM, Cho J, Kim HK, Lee HY
Eur Radiol 2024 Dec;34(12):7817-7828. Epub 2024 Jun 8 doi: 10.1007/s00330-024-10835-z. PMID: 38850308
Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.
Steinfort DP, Kothari G, Wallace N, Hardcastle N, Rangamuwa K, Dieleman EMT, Lee P, Li P, Simpson JA, Yo S, Bashirdazeh F, Nguyen P, Jennings BR, Fielding D, Crombag L, Irving LB, Yasufuku K, Annema JT, Ost DE, Siva S
Lancet Respir Med 2024 Jun;12(6):467-475. Epub 2024 Mar 12 doi: 10.1016/S2213-2600(24)00010-9. PMID: 38490228
PET/CT based cross-modal deep learning signature to predict occult nodal metastasis in lung cancer.
Zhong Y, Cai C, Chen T, Gui H, Deng J, Yang M, Yu B, Song Y, Wang T, Sun X, Shi J, Chen Y, Xie D, Chen C, She Y
Nat Commun 2023 Nov 18;14(1):7513. doi: 10.1038/s41467-023-42811-4. PMID: 37980411Free PMC Article
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567

Recent systematic reviews

Systematic review and meta-analysis of the prognostic impact of lymph node micrometastasis and isolated tumour cells in patients with stage I-IIIA non-small cell lung cancer.
Hüyük M, Fiocco M, Postmus PE, Cohen D, von der Thüsen JH
Histopathology 2023 Apr;82(5):650-663. Epub 2022 Nov 9 doi: 10.1111/his.14831. PMID: 36282087
Predictive Value of 18F-Fluorodeoxyglucose Positron Emission Tomography or Positron Emission Tomography/Computed Tomography for Assessment of Occult Lymph Node Metastasis in Non-Small Cell Lung Cancer.
Seol HY, Kim YS, Kim SJ
Oncology 2021;99(2):96-104. Epub 2020 Sep 25 doi: 10.1159/000509988. PMID: 32980838
Preoperative Staging by EBUS in cN0/N1 Lung Cancer: Systematic Review and Meta-Analysis.
Leong TL, Loveland PM, Gorelik A, Irving L, Steinfort DP
J Bronchology Interv Pulmonol 2019 Jul;26(3):155-165. doi: 10.1097/LBR.0000000000000545. PMID: 30119069
Endobronchial Ultrasound for Nodal Staging of Patients with Non-Small-Cell Lung Cancer with Radiologically Normal Mediastinum. A Meta-Analysis.
El-Osta H, Jani P, Mansour A, Rascoe P, Jafri S
Ann Am Thorac Soc 2018 Jul;15(7):864-874. doi: 10.1513/AnnalsATS.201711-863OC. PMID: 29684288
Nodal recurrence after stereotactic body radiotherapy for early stage non-small cell lung cancer: Incidence and proposed risk factors.
Wink KCJ, van Baardwijk A, Troost EGC, De Ruysscher D
Cancer Treat Rev 2017 May;56:8-15. Epub 2017 Apr 12 doi: 10.1016/j.ctrv.2017.04.001. PMID: 28437679

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