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Stage II Centroblastic Follicular Lymphoma

MedGen UID:
276863
•Concept ID:
C1519508
•
Neoplastic Process

Definition

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage II Centroblastic Follicular Lymphoma

Professional guidelines

PubMed

Current status and future perspectives in the treatment of low-grade non-Hodgkin's lymphomas.
Hiddemann W, Unterhalt M
Blood Rev 1994 Dec;8(4):225-33. doi: 10.1016/0268-960x(94)90110-4. PMID: 7888829
The natural history of low grade non-Hodgkin's lymphoma and the impact of a no initial treatment policy on survival.
O'Brien ME, Easterbrook P, Powell J, Blackledge GR, Jones L, MacLennan IC, Leonard RC
Q J Med 1991 Aug;80(292):651-60. PMID: 1754669

Recent clinical studies

Etiology

Long-term outcome and prognostic factors in early-stage nodal low-grade non-hodgkin's lymphomas treated with radiation therapy.
Eich HT, Heimann M, Stützer H, Kriz J, Reiser M, Müller RP
Strahlenther Onkol 2009 May;185(5):288-95. Epub 2009 May 15 doi: 10.1007/s00066-009-1937-4. PMID: 19440667
IDEC-C2B8 (Rituximab) anti-CD20 antibody treatment in relapsed advanced-stage follicular lymphomas: results of a phase-II study of the German Low-Grade Lymphoma Study Group.
Feuring-Buske M, Kneba M, Unterhalt M, Engert A, Gramatzki M, Hiller E, Trümper L, Brugger W, Ostermann H, Atzpodien J, Hallek M, Aulitzky E, Hiddemann W
Ann Hematol 2000 Sep;79(9):493-500. doi: 10.1007/s002770000163. PMID: 11043420
Extended field and total central lymphatic radiotherapy in the treatment of early stage lymph node centroblastic-centrocytic lymphomas: results of a prospective multicenter study. Study Group NHL-frühe Stadien.
Stuschke M, Hoederath A, Sack H, Pötter R, Müller RP, Schulz U, Karstens J, Makoski HB
Cancer 1997 Dec 15;80(12):2273-84. doi: 10.1002/(sici)1097-0142(19971215)80:12<2273::aid-cncr9>3.0.co;2-v. PMID: 9404705
Current status and future perspectives in the treatment of low-grade non-Hodgkin's lymphomas.
Hiddemann W, Unterhalt M
Blood Rev 1994 Dec;8(4):225-33. doi: 10.1016/0268-960x(94)90110-4. PMID: 7888829
Primary non-Hodgkin's lymphomas of the female breast.
Giardini R, Piccolo C, Rilke F
Cancer 1992 Feb 1;69(3):725-35. doi: 10.1002/1097-0142(19920201)69:3<725::aid-cncr2820690320>3.0.co;2-c. PMID: 1730123

Diagnosis

IDEC-C2B8 (Rituximab) anti-CD20 antibody treatment in relapsed advanced-stage follicular lymphomas: results of a phase-II study of the German Low-Grade Lymphoma Study Group.
Feuring-Buske M, Kneba M, Unterhalt M, Engert A, Gramatzki M, Hiller E, Trümper L, Brugger W, Ostermann H, Atzpodien J, Hallek M, Aulitzky E, Hiddemann W
Ann Hematol 2000 Sep;79(9):493-500. doi: 10.1007/s002770000163. PMID: 11043420
Current status and future perspectives in the treatment of low-grade non-Hodgkin's lymphomas.
Hiddemann W, Unterhalt M
Blood Rev 1994 Dec;8(4):225-33. doi: 10.1016/0268-960x(94)90110-4. PMID: 7888829
Primary non-Hodgkin's lymphomas of the female breast.
Giardini R, Piccolo C, Rilke F
Cancer 1992 Feb 1;69(3):725-35. doi: 10.1002/1097-0142(19920201)69:3<725::aid-cncr2820690320>3.0.co;2-c. PMID: 1730123
Non-Hodgkin's lymphoma in the elderly. A study of 602 patients aged 70 or older from a Danish population-based registry. The Danish LYEO-Study Group.
d'Amore F, Brincker H, Christensen BE, Thorling K, Pedersen M, Nielsen JL, Sandberg E, Pedersen NT, Sørensen E
Ann Oncol 1992 May;3(5):379-86. doi: 10.1093/oxfordjournals.annonc.a058211. PMID: 1616892
Mitotic activity in non-Hodgkin's lymphoma. Relation to the Kiel classification and to prognosis.
Akerman M, Brandt L, Johnson A, Olsson H
Br J Cancer 1987 Feb;55(2):219-23. doi: 10.1038/bjc.1987.41. PMID: 3814492Free PMC Article

Therapy

IDEC-C2B8 (Rituximab) anti-CD20 antibody treatment in relapsed advanced-stage follicular lymphomas: results of a phase-II study of the German Low-Grade Lymphoma Study Group.
Feuring-Buske M, Kneba M, Unterhalt M, Engert A, Gramatzki M, Hiller E, Trümper L, Brugger W, Ostermann H, Atzpodien J, Hallek M, Aulitzky E, Hiddemann W
Ann Hematol 2000 Sep;79(9):493-500. doi: 10.1007/s002770000163. PMID: 11043420
Extended field and total central lymphatic radiotherapy in the treatment of early stage lymph node centroblastic-centrocytic lymphomas: results of a prospective multicenter study. Study Group NHL-frühe Stadien.
Stuschke M, Hoederath A, Sack H, Pötter R, Müller RP, Schulz U, Karstens J, Makoski HB
Cancer 1997 Dec 15;80(12):2273-84. doi: 10.1002/(sici)1097-0142(19971215)80:12<2273::aid-cncr9>3.0.co;2-v. PMID: 9404705
Current status and future perspectives in the treatment of low-grade non-Hodgkin's lymphomas.
Hiddemann W, Unterhalt M
Blood Rev 1994 Dec;8(4):225-33. doi: 10.1016/0268-960x(94)90110-4. PMID: 7888829
The natural history of low grade non-Hodgkin's lymphoma and the impact of a no initial treatment policy on survival.
O'Brien ME, Easterbrook P, Powell J, Blackledge GR, Jones L, MacLennan IC, Leonard RC
Q J Med 1991 Aug;80(292):651-60. PMID: 1754669

Prognosis

Extranodal diffuse large B cell lymphoma of cutaneous follicle centre lymphoma type: a study of 24 patients with non-cutaneous primary limited stage extranodal diffuse large B cell lymphoma in support of a new concept.
Aigner F, Korol D, Schmitt AM, Kurrer MO
Histopathology 2012 Apr;60(5):774-84. Epub 2012 Feb 3 doi: 10.1111/j.1365-2559.2011.04122.x. PMID: 22304695
Extended field and total central lymphatic radiotherapy in the treatment of early stage lymph node centroblastic-centrocytic lymphomas: results of a prospective multicenter study. Study Group NHL-frühe Stadien.
Stuschke M, Hoederath A, Sack H, Pötter R, Müller RP, Schulz U, Karstens J, Makoski HB
Cancer 1997 Dec 15;80(12):2273-84. doi: 10.1002/(sici)1097-0142(19971215)80:12<2273::aid-cncr9>3.0.co;2-v. PMID: 9404705
Current status and future perspectives in the treatment of low-grade non-Hodgkin's lymphomas.
Hiddemann W, Unterhalt M
Blood Rev 1994 Dec;8(4):225-33. doi: 10.1016/0268-960x(94)90110-4. PMID: 7888829
Primary non-Hodgkin's lymphomas of the female breast.
Giardini R, Piccolo C, Rilke F
Cancer 1992 Feb 1;69(3):725-35. doi: 10.1002/1097-0142(19920201)69:3<725::aid-cncr2820690320>3.0.co;2-c. PMID: 1730123
Mitotic activity in non-Hodgkin's lymphoma. Relation to the Kiel classification and to prognosis.
Akerman M, Brandt L, Johnson A, Olsson H
Br J Cancer 1987 Feb;55(2):219-23. doi: 10.1038/bjc.1987.41. PMID: 3814492Free PMC Article

Clinical prediction guides

Long-term outcome and prognostic factors in early-stage nodal low-grade non-hodgkin's lymphomas treated with radiation therapy.
Eich HT, Heimann M, Stützer H, Kriz J, Reiser M, Müller RP
Strahlenther Onkol 2009 May;185(5):288-95. Epub 2009 May 15 doi: 10.1007/s00066-009-1937-4. PMID: 19440667
IDEC-C2B8 (Rituximab) anti-CD20 antibody treatment in relapsed advanced-stage follicular lymphomas: results of a phase-II study of the German Low-Grade Lymphoma Study Group.
Feuring-Buske M, Kneba M, Unterhalt M, Engert A, Gramatzki M, Hiller E, Trümper L, Brugger W, Ostermann H, Atzpodien J, Hallek M, Aulitzky E, Hiddemann W
Ann Hematol 2000 Sep;79(9):493-500. doi: 10.1007/s002770000163. PMID: 11043420
Current status and future perspectives in the treatment of low-grade non-Hodgkin's lymphomas.
Hiddemann W, Unterhalt M
Blood Rev 1994 Dec;8(4):225-33. doi: 10.1016/0268-960x(94)90110-4. PMID: 7888829

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