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Ovarian yolk sac tumor, hepatoid pattern

MedGen UID:
276676
•Concept ID:
C1518748
•
Neoplastic Process
Synonyms: hepatoid pattern ovarian yolk sac tumor; hepatoid pattern ovarian yolk sac tumour; Ovarian Yolk Sac Tumor, Hepatoid Pattern; ovarian yolk sac tumor, hepatoid pattern; ovarian yolk Sac tumor, hepatoid pattern
 
Monarch Initiative: MONDO:0003906

Definition

A yolk sac tumor that arises from the ovary and is characterized by the presence of extensive differentiation into hepatic tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian yolk sac tumor, hepatoid pattern

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Hepatocyte paraffin 1 antibody does not distinguish primary ovarian tumors with hepatoid differentiation from metastatic hepatocellular carcinoma.
Pitman MB, Triratanachat S, Young RH, Oliva E
Int J Gynecol Pathol 2004 Jan;23(1):58-64. doi: 10.1097/01.pgp.0000101141.31270.a1. PMID: 14668552
Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group.
Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP
Am J Surg Pathol 1998 Sep;22(9):1115-24. doi: 10.1097/00000478-199809000-00011. PMID: 9737245
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512

Diagnosis

Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
The yolk sac tumor: reflections on a remarkable neoplasm and two of the many intrigued by it-Gunnar Teilum and Aleksander Talerman-and the bond it formed between them.
Young RH
Int J Surg Pathol 2014 Dec;22(8):677-87. Epub 2014 Nov 12 doi: 10.1177/1066896914558265. PMID: 25395492
Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors.
McCluggage WG, Young RH
Semin Diagn Pathol 2005 Feb;22(1):3-32. doi: 10.1053/j.semdp.2005.11.002. PMID: 16512597
Cytopathologic and clinicopathologic features of ovarian hepatoid carcinoma. A case report.
Watanabe Y, Umemoto M, Ueda H, Nakai H, Hoshiai H, Noda K
Acta Cytol 2003 Jan-Feb;47(1):78-82. doi: 10.1159/000326479. PMID: 12585035
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512

Therapy

Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman.
Isonishi S, Ogura A, Kiyokawa T, Suzuki M, Kunito S, Hirama M, Tachibana T, Ochiai K, Tanaka T
Int J Clin Oncol 2009 Feb;14(1):70-3. Epub 2009 Feb 20 doi: 10.1007/s10147-008-0800-4. PMID: 19225928

Prognosis

Hepatoid malignancy of unknown origin--a diagnostic conundrum: review of literature and case report of collision with adenocarcinoma.
Gopaldas R, Kunasani R, Plymyer MR, Bloch RS
Surg Oncol 2005 Jul;14(1):11-25. Epub 2004 Dec 9 doi: 10.1016/j.suronc.2004.09.011. PMID: 15777886
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group.
Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP
Am J Surg Pathol 1998 Sep;22(9):1115-24. doi: 10.1097/00000478-199809000-00011. PMID: 9737245

Clinical prediction guides

Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Hepatoid malignancy of unknown origin--a diagnostic conundrum: review of literature and case report of collision with adenocarcinoma.
Gopaldas R, Kunasani R, Plymyer MR, Bloch RS
Surg Oncol 2005 Jul;14(1):11-25. Epub 2004 Dec 9 doi: 10.1016/j.suronc.2004.09.011. PMID: 15777886
Hepatoid carcinoma of the ovary: characteristics of its immunoreactivity. A case report.
Tsung JS, Yang PS
Eur J Gynaecol Oncol 2004;25(6):745-8. PMID: 15597858
Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group.
Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP
Am J Surg Pathol 1998 Sep;22(9):1115-24. doi: 10.1097/00000478-199809000-00011. PMID: 9737245

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