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Oncogene Deregulation

MedGen UID:
276628
•Concept ID:
C1518576
•
Cell or Molecular Dysfunction
Synonym: Gene Deregulation

Professional guidelines

PubMed

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer.
Yu L, Wei J, Liu P
Semin Cancer Biol 2022 Oct;85:69-94. Epub 2021 Jun 25 doi: 10.1016/j.semcancer.2021.06.019. PMID: 34175443
MYC as a target for cancer treatment.
Duffy MJ, O'Grady S, Tang M, Crown J
Cancer Treat Rev 2021 Mar;94:102154. Epub 2021 Jan 19 doi: 10.1016/j.ctrv.2021.102154. PMID: 33524794
Double hit and double expressors in lymphoma: Definition and treatment.
Riedell PA, Smith SM
Cancer 2018 Dec 15;124(24):4622-4632. Epub 2018 Sep 25 doi: 10.1002/cncr.31646. PMID: 30252929

Recent clinical studies

Etiology

The genomic basis of childhood T-lineage acute lymphoblastic leukaemia.
Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, Montefiori LE, Wood BL, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt KM, Devidas M, Winter SS, Dunsmore KP, Inaba H, Carroll WL, Ramirez NC, Phillips AH, Kriwacki RW, Yang JJ, Vincent TL, Zhao Y, Ghate PS, Wang J, Reilly C, Zhou X, Sanders MA, Takita J, Kato M, Takasugi N, Chang BH, Press RD, Loh M, Rampersaud E, Raetz E, Hunger SP, Tan K, Chang TC, Wu G, Pounds SB, Mullighan CG, Teachey DT
Nature 2024 Aug;632(8027):1082-1091. Epub 2024 Aug 14 doi: 10.1038/s41586-024-07807-0. PMID: 39143224
The performance of the HPV16 real-time PCR integration assay.
Ruutu MP, Kulmala SM, Peitsaro P, Syrjänen SM
Clin Biochem 2008 Apr;41(6):423-8. Epub 2008 Jan 3 doi: 10.1016/j.clinbiochem.2007.12.014. PMID: 18206116
Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?
Pett M, Coleman N
J Pathol 2007 Aug;212(4):356-67. doi: 10.1002/path.2192. PMID: 17573670
Myeloma aetiology and epidemiology.
Morgan GJ, Davies FE, Linet M
Biomed Pharmacother 2002 Jul;56(5):223-34. doi: 10.1016/s0753-3322(02)00194-4. PMID: 12199621

Diagnosis

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma.
Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD
Nat Commun 2018 Oct 1;9(1):4001. doi: 10.1038/s41467-018-06354-3. PMID: 30275490Free PMC Article
An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link.
Kelly GL, Long HM, Stylianou J, Thomas WA, Leese A, Bell AI, Bornkamm GW, Mautner J, Rickinson AB, Rowe M
PLoS Pathog 2009 Mar;5(3):e1000341. Epub 2009 Mar 13 doi: 10.1371/journal.ppat.1000341. PMID: 19283066Free PMC Article
The performance of the HPV16 real-time PCR integration assay.
Ruutu MP, Kulmala SM, Peitsaro P, Syrjänen SM
Clin Biochem 2008 Apr;41(6):423-8. Epub 2008 Jan 3 doi: 10.1016/j.clinbiochem.2007.12.014. PMID: 18206116

Therapy

Extrachromosomal DNA amplifications in cancer.
Yi E, Chamorro González R, Henssen AG, Verhaak RGW
Nat Rev Genet 2022 Dec;23(12):760-771. Epub 2022 Aug 11 doi: 10.1038/s41576-022-00521-5. PMID: 35953594Free PMC Article

Prognosis

The genomic basis of childhood T-lineage acute lymphoblastic leukaemia.
Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, Montefiori LE, Wood BL, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt KM, Devidas M, Winter SS, Dunsmore KP, Inaba H, Carroll WL, Ramirez NC, Phillips AH, Kriwacki RW, Yang JJ, Vincent TL, Zhao Y, Ghate PS, Wang J, Reilly C, Zhou X, Sanders MA, Takita J, Kato M, Takasugi N, Chang BH, Press RD, Loh M, Rampersaud E, Raetz E, Hunger SP, Tan K, Chang TC, Wu G, Pounds SB, Mullighan CG, Teachey DT
Nature 2024 Aug;632(8027):1082-1091. Epub 2024 Aug 14 doi: 10.1038/s41586-024-07807-0. PMID: 39143224
High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation.
Rico D, Kent D, Karataraki N, Mikulasova A, Berlinguer-Palmini R, Walker BA, Javierre BM, Russell LJ, Brackley CA
Genome Res 2022 Jul 27;32(7):1355-1366. doi: 10.1101/gr.276028.121. PMID: 35863900Free PMC Article
Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma.
Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD
Nat Commun 2018 Oct 1;9(1):4001. doi: 10.1038/s41467-018-06354-3. PMID: 30275490Free PMC Article
Gα12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma.
Yang YM, Lee WH, Lee CG, An J, Kim ES, Kim SH, Lee SK, Lee CH, Dhanasekaran DN, Moon A, Hwang S, Lee SJ, Park JW, Kim KM, Kim SG
Oncogene 2015 May 28;34(22):2910-21. Epub 2014 Jul 28 doi: 10.1038/onc.2014.218. PMID: 25065598

Clinical prediction guides

The genomic basis of childhood T-lineage acute lymphoblastic leukaemia.
Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, Montefiori LE, Wood BL, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt KM, Devidas M, Winter SS, Dunsmore KP, Inaba H, Carroll WL, Ramirez NC, Phillips AH, Kriwacki RW, Yang JJ, Vincent TL, Zhao Y, Ghate PS, Wang J, Reilly C, Zhou X, Sanders MA, Takita J, Kato M, Takasugi N, Chang BH, Press RD, Loh M, Rampersaud E, Raetz E, Hunger SP, Tan K, Chang TC, Wu G, Pounds SB, Mullighan CG, Teachey DT
Nature 2024 Aug;632(8027):1082-1091. Epub 2024 Aug 14 doi: 10.1038/s41586-024-07807-0. PMID: 39143224
Extrachromosomal DNA amplifications in cancer.
Yi E, Chamorro González R, Henssen AG, Verhaak RGW
Nat Rev Genet 2022 Dec;23(12):760-771. Epub 2022 Aug 11 doi: 10.1038/s41576-022-00521-5. PMID: 35953594Free PMC Article
High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation.
Rico D, Kent D, Karataraki N, Mikulasova A, Berlinguer-Palmini R, Walker BA, Javierre BM, Russell LJ, Brackley CA
Genome Res 2022 Jul 27;32(7):1355-1366. doi: 10.1101/gr.276028.121. PMID: 35863900Free PMC Article
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.
Ottema S, Mulet-Lazaro R, Erpelinck-Verschueren C, van Herk S, Havermans M, Arricibita Varea A, Vermeulen M, Beverloo HB, Gröschel S, Haferlach T, Haferlach C, J Wouters B, Bindels E, Smeenk L, Delwel R
Nat Commun 2021 Sep 28;12(1):5679. doi: 10.1038/s41467-021-25862-3. PMID: 34584081Free PMC Article
Gα12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma.
Yang YM, Lee WH, Lee CG, An J, Kim ES, Kim SH, Lee SK, Lee CH, Dhanasekaran DN, Moon A, Hwang S, Lee SJ, Park JW, Kim KM, Kim SG
Oncogene 2015 May 28;34(22):2910-21. Epub 2014 Jul 28 doi: 10.1038/onc.2014.218. PMID: 25065598

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