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Skin clear cell basal cell carcinoma

MedGen UID:
275752
•Concept ID:
C1516599
•
Neoplastic Process
Synonyms: Clear Cell Basal Cell Carcinoma; clear cell basal cell carcinoma; Skin Clear Cell Basal Cell Carcinoma; skin clear cell basal cell carcinoma
 
Monarch Initiative: MONDO:0002950

Definition

A morphologic variant of basal cell carcinoma characterized by the presence of clear cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin clear cell basal cell carcinoma

Professional guidelines

PubMed

Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Current Basal and Squamous Cell Skin Cancer Management.
Mendez BM, Thornton JF
Plast Reconstr Surg 2018 Sep;142(3):373e-387e. doi: 10.1097/PRS.0000000000004696. PMID: 30148788
Diagnosis and treatment of Basal cell and squamous cell carcinoma.
Firnhaber JM
Am Fam Physician 2012 Jul 15;86(2):161-8. PMID: 22962928

Recent clinical studies

Etiology

PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in Skin Cancer.
Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Scalp basal cell carcinoma: A different entity?
Castanheira A, Soares P, Boaventura P
Dermatol Ther 2019 Mar;32(2):e12828. Epub 2019 Jan 30 doi: 10.1111/dth.12828. PMID: 30659714
Molecular basis of basal cell carcinoma.
Montagna E, Lopes OS
An Bras Dermatol 2017 Jul-Aug;92(4):517-520. doi: 10.1590/abd1806-4841.20176544. PMID: 28954101Free PMC Article

Diagnosis

PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in Skin Cancer.
Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Non-melanoma skin cancer.
Madan V, Lear JT, Szeimies RM
Lancet 2010 Feb 20;375(9715):673-85. doi: 10.1016/S0140-6736(09)61196-X. PMID: 20171403
Desmoplastic trichoepithelioma.
Mamelak AJ, Goldberg LH, Katz TM, Graves JJ, Arnon O, Kimyai-Asadi A
J Am Acad Dermatol 2010 Jan;62(1):102-106. doi: 10.1016/j.jaad.2009.06.066. PMID: 20082889

Therapy

Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges.
Karim M, Boikess RS, Schwartz RA, Cohen PJ
Arch Dermatol Res 2023 Aug;315(6):1465-1472. Epub 2022 Dec 2 doi: 10.1007/s00403-022-02494-1. PMID: 36459193
Scalp basal cell carcinoma: A different entity?
Castanheira A, Soares P, Boaventura P
Dermatol Ther 2019 Mar;32(2):e12828. Epub 2019 Jan 30 doi: 10.1111/dth.12828. PMID: 30659714
Sun protection for preventing basal cell and squamous cell skin cancers.
Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2016 Jul 25;7(7):CD011161. doi: 10.1002/14651858.CD011161.pub2. PMID: 27455163Free PMC Article
Emerging drugs and combination strategies for basal cell carcinoma.
Dreier J, Dummer R, Felderer L, Nägeli M, Gobbi S, Kunstfeld R
Expert Opin Emerg Drugs 2014 Sep;19(3):353-65. Epub 2014 Apr 29 doi: 10.1517/14728214.2014.914171. PMID: 24773312
Non-melanoma skin cancer.
Madan V, Lear JT, Szeimies RM
Lancet 2010 Feb 20;375(9715):673-85. doi: 10.1016/S0140-6736(09)61196-X. PMID: 20171403

Prognosis

PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in Skin Cancer.
Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Basal cell carcinoma: an emerging epidemic in women in Iceland.
Adalsteinsson JA, Ratner D, Olafsdóttir E, Grant-Kels J, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L
Br J Dermatol 2020 Nov;183(5):847-856. Epub 2020 Mar 13 doi: 10.1111/bjd.18937. PMID: 32030719
Epithelial-Mesenchymal Transition in Skin Cancers: A Review.
Hodorogea A, Calinescu A, Antohe M, Balaban M, Nedelcu RI, Turcu G, Ion DA, Badarau IA, Popescu CM, Popescu R, Popp C, Cioplea M, Nichita L, Hulea I, Brinzea A
Anal Cell Pathol (Amst) 2019;2019:3851576. Epub 2019 Dec 16 doi: 10.1155/2019/3851576. PMID: 31934531Free PMC Article
Molecular basis of basal cell carcinoma.
Montagna E, Lopes OS
An Bras Dermatol 2017 Jul-Aug;92(4):517-520. doi: 10.1590/abd1806-4841.20176544. PMID: 28954101Free PMC Article
Non-melanoma skin cancer.
Madan V, Lear JT, Szeimies RM
Lancet 2010 Feb 20;375(9715):673-85. doi: 10.1016/S0140-6736(09)61196-X. PMID: 20171403

Clinical prediction guides

Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges.
Karim M, Boikess RS, Schwartz RA, Cohen PJ
Arch Dermatol Res 2023 Aug;315(6):1465-1472. Epub 2022 Dec 2 doi: 10.1007/s00403-022-02494-1. PMID: 36459193
PRE-SURGICAL DIAGNOSTIC PARALLELS IN BASAL CELL CARCINOMA OF THE SKIN.
Zaychenko Y, Kucher A, Mota I, Kiladze N
Georgian Med News 2022 Jan;(322):90-94. PMID: 35134767
Basal cell carcinoma: an emerging epidemic in women in Iceland.
Adalsteinsson JA, Ratner D, Olafsdóttir E, Grant-Kels J, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L
Br J Dermatol 2020 Nov;183(5):847-856. Epub 2020 Mar 13 doi: 10.1111/bjd.18937. PMID: 32030719
Ultrasonographic features of superficial and nodular basal cell carcinoma.
Khlebnikova AN, Molochkov VA, Selezneva EV, Belova LA, Bezugly A, Molochkov AV
Med Ultrason 2018 Dec 8;20(4):475-479. doi: 10.11152/mu-1633. PMID: 30534655
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Recent systematic reviews

Surgery Alone (Without Adjuvant Radiation) Adequately Treats Histologic Perineural Basal Cell Carcinomas: A Systematic Review With Meta-Analysis.
Ash MM, Lacy FA, Patel J, Varma R
Dermatol Surg 2023 Jan 1;49(1):1-7. doi: 10.1097/DSS.0000000000003640. PMID: 36533788
Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults.
Ferrante di Ruffano L, Dinnes J, Chuchu N, Bayliss SE, Takwoingi Y, Davenport C, Matin RN, O'Sullivan C, Roskell D, Deeks JJ, Williams HC; Cochrane Skin Cancer Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD013187. doi: 10.1002/14651858.CD013187. PMID: 30521689Free PMC Article
Sun protection for preventing basal cell and squamous cell skin cancers.
Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2016 Jul 25;7(7):CD011161. doi: 10.1002/14651858.CD011161.pub2. PMID: 27455163Free PMC Article
Telomere length and the risk of cutaneous melanoma and non-melanoma skin cancer: a review of the literature and meta-analysis.
Caini S, Raimondi S, Johansson H, De Giorgi V, Zanna I, Palli D, Gandini S
J Dermatol Sci 2015 Dec;80(3):168-74. Epub 2015 Aug 22 doi: 10.1016/j.jdermsci.2015.08.003. PMID: 26341697
A systematic review of photodynamic therapy in the treatment of pre-cancerous skin conditions, Barrett's oesophagus and cancers of the biliary tract, brain, head and neck, lung, oesophagus and skin.
Fayter D, Corbett M, Heirs M, Fox D, Eastwood A
Health Technol Assess 2010 Jul;14(37):1-288. doi: 10.3310/hta14370. PMID: 20663420

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