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Hypercalcemic type ovarian small cell carcinoma

MedGen UID:
275294
•Concept ID:
C1518736
•
Neoplastic Process
Synonyms: hypercalcemic type ovarian small cell carcinoma; Ovarian Small Cell Carcinoma, Hypercalcemic Type; ovarian small cell carcinoma, hypercalcemic type; SCCOHT
 
Monarch Initiative: MONDO:0004319

Definition

An undifferentiated small cell carcinoma that arises from the ovary and is associated with hypercalcemia. Electron microscopic studies show neurosecretory granules are either absent or, when present, are in small numbers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypercalcemic type ovarian small cell carcinoma

Professional guidelines

PubMed

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Rare non-epithelial ovarian neoplasms: Pathology, genetics and treatment.
Foulkes WD, Gore M, McCluggage WG
Gynecol Oncol 2016 Jul;142(1):190-198. Epub 2016 Apr 19 doi: 10.1016/j.ygyno.2016.04.005. PMID: 27079213
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Recent clinical studies

Etiology

Neuroendocrine neoplasms of the ovary: a review of 63 cases.
Flores Legarreta A, Saab R, Gonzales NR, Chisholm GB, Westin SN, Hillman RT, Frumovitz M
Int J Gynecol Cancer 2024 Apr 1;34(4):566-573. doi: 10.1136/ijgc-2023-005063. PMID: 38290783
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Ovarian sex-cord stromal tumours and small cell tumours: Pathological, genetic and management aspects.
Boussios S, Moschetta M, Zarkavelis G, Papadaki A, Kefas A, Tatsi K
Crit Rev Oncol Hematol 2017 Dec;120:43-51. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.007. PMID: 29198337
Rare non-epithelial ovarian neoplasms: Pathology, genetics and treatment.
Foulkes WD, Gore M, McCluggage WG
Gynecol Oncol 2016 Jul;142(1):190-198. Epub 2016 Apr 19 doi: 10.1016/j.ygyno.2016.04.005. PMID: 27079213

Diagnosis

Fertility preservation in rare ovarian tumors.
Chelariu-Raicu A, Cobb LP, Gershenson DM
Int J Gynecol Cancer 2021 Mar;31(3):432-441. doi: 10.1136/ijgc-2020-001775. PMID: 33649010
Pembrolizumab-Induced Thyroiditis.
Imblum BA, Baloch ZW, Fraker D, LiVolsi VA
Endocr Pathol 2019 Jun;30(2):163-167. doi: 10.1007/s12022-019-9579-2. PMID: 31111437
Gynecological neoplasms associated with paraneoplastic hypercalcemia.
Lim D, Oliva E
Semin Diagn Pathol 2019 Jul;36(4):246-259. Epub 2019 Feb 1 doi: 10.1053/j.semdp.2019.01.003. PMID: 30772079
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Clinical and Imaging Review.
Korivi BR, Javadi S, Faria S, Sagebiel T, Garg N, Patnana M, Prasad SR
Curr Probl Diagn Radiol 2018 Sep;47(5):333-339. Epub 2017 Sep 1 doi: 10.1067/j.cpradiol.2017.08.004. PMID: 28943050
Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (Malignant Rhabdoid Tumor of the Ovary): A Review with Recent Developments on Pathogenesis.
Witkowski L, Goudie C, Foulkes WD, McCluggage WG
Surg Pathol Clin 2016 Jun;9(2):215-26. Epub 2016 Apr 12 doi: 10.1016/j.path.2016.01.005. PMID: 27241105

Therapy

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Pembrolizumab-Induced Thyroiditis.
Imblum BA, Baloch ZW, Fraker D, LiVolsi VA
Endocr Pathol 2019 Jun;30(2):163-167. doi: 10.1007/s12022-019-9579-2. PMID: 31111437
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
Fukumoto T, Magno E, Zhang R
Mol Cancer Res 2018 Dec;16(12):1819-1825. Epub 2018 Jul 23 doi: 10.1158/1541-7786.MCR-18-0368. PMID: 30037854Free PMC Article
Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics.
Gamwell LF, Gambaro K, Merziotis M, Crane C, Arcand SL, Bourada V, Davis C, Squire JA, Huntsman DG, Tonin PN, Vanderhyden BC
Orphanet J Rare Dis 2013 Feb 21;8:33. doi: 10.1186/1750-1172-8-33. PMID: 23433318Free PMC Article
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Prognosis

Neuroendocrine neoplasms of the ovary: a review of 63 cases.
Flores Legarreta A, Saab R, Gonzales NR, Chisholm GB, Westin SN, Hillman RT, Frumovitz M
Int J Gynecol Cancer 2024 Apr 1;34(4):566-573. doi: 10.1136/ijgc-2023-005063. PMID: 38290783
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Clinical and Imaging Review.
Korivi BR, Javadi S, Faria S, Sagebiel T, Garg N, Patnana M, Prasad SR
Curr Probl Diagn Radiol 2018 Sep;47(5):333-339. Epub 2017 Sep 1 doi: 10.1067/j.cpradiol.2017.08.004. PMID: 28943050
Ovarian sex-cord stromal tumours and small cell tumours: Pathological, genetic and management aspects.
Boussios S, Moschetta M, Zarkavelis G, Papadaki A, Kefas A, Tatsi K
Crit Rev Oncol Hematol 2017 Dec;120:43-51. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.007. PMID: 29198337

Clinical prediction guides

Neuroendocrine neoplasms of the ovary: a review of 63 cases.
Flores Legarreta A, Saab R, Gonzales NR, Chisholm GB, Westin SN, Hillman RT, Frumovitz M
Int J Gynecol Cancer 2024 Apr 1;34(4):566-573. doi: 10.1136/ijgc-2023-005063. PMID: 38290783
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Garg K, Karnezis AN, Rabban JT
Pathology 2018 Feb;50(2):238-256. Epub 2018 Jan 17 doi: 10.1016/j.pathol.2017.10.009. PMID: 29373116
Hypercalcemic type of small cell carcinoma of the ovary.
Ilić MB, Jovanović DV, Milosavljević MZ, Stanković V, Djordjević G, Protrka Z, Nedović J, Mitrović SLj
Vojnosanit Pregl 2015 Mar;72(3):295-8. doi: 10.2298/vsp1503295i. PMID: 25958485
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

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