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Pancreatic mucinous-cystic neoplasm

MedGen UID:
274120
•Concept ID:
C1518872
•
Neoplastic Process
Synonyms: mucinous cystic neoplasm; Pancreatic Mucinous Cystic Neoplasm; Pancreatic mucinous cystic neoplasm; Pancreatic Mucinous-Cystic Neoplasm; pancreatic mucinous-cystic neoplasm
 
Monarch Initiative: MONDO:0044879

Definition

A non-invasive or invasive cystic epithelial neoplasm that affects almost exclusively females. It is characterized by the presence of columnar mucin-producing epithelial cells and ovarian-type stroma formation. [from NCI]

Professional guidelines

PubMed

Validation of Sendai and Fukuoka consensus guidelines in predicting malignancy in patients with preoperatively diagnosed mucinous pancreatic cystic neoplasms.
Zhou W, Xu Y, Rong Y, Wu W, Kuang T, Xin B, Zhu H, Lou W, Wang D
J Surg Oncol 2018 Mar;117(3):409-416. Epub 2017 Oct 16 doi: 10.1002/jso.24882. PMID: 29044541
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

Recent clinical studies

Therapy

An indeterminate mucin-producing cystic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant cells: a case report of a rare association of pancreatic tumors.
Chiarelli M, Guttadauro A, Gerosa M, Marando A, Gabrielli F, De Simone M, Cioffi U
BMC Gastroenterol 2015 Nov 18;15:161. doi: 10.1186/s12876-015-0391-2. PMID: 26581412Free PMC Article
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

Prognosis

RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm.
Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y
Virchows Arch 2022 Jun;480(6):1189-1199. Epub 2022 Jan 23 doi: 10.1007/s00428-022-03277-9. PMID: 35066614
A nomogram for predicting pancreatic mucinous cystic neoplasm and serous cystic neoplasm.
Shao C, Feng X, Yu J, Meng Y, Liu F, Zhang H, Fang X, Li J, Wang L, Jiang H, Lu J, Bian Y
Abdom Radiol (NY) 2021 Aug;46(8):3963-3973. Epub 2021 Mar 22 doi: 10.1007/s00261-021-03038-3. PMID: 33748881
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Pancreatic mucinous cystic neoplasm in a transgender patient.
Foster D, Shaikh MF, Gleeson E, Babcock BD, Lin J, Ownbey RT, Hysell ME, Ringold D, Bowne WB
World J Surg Oncol 2015 Jun 24;13:205. doi: 10.1186/s12957-015-0620-8. PMID: 26104783Free PMC Article
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

Clinical prediction guides

Intralobular distribution of ovarian-like stroma in pancreatic mucinous cystic neoplasms: a discussion on its tumorigenesis.
Fukumura Y, Kinowaki Y, Matsuda Y, Takase M, Tonosaki M, Minagawa M, Saiura A, Tanabe M, Okano K, Suzuki Y, Kato K, Yao T
Sci Rep 2022 Feb 28;12(1):3326. doi: 10.1038/s41598-022-07416-9. PMID: 35228647Free PMC Article
RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm.
Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y
Virchows Arch 2022 Jun;480(6):1189-1199. Epub 2022 Jan 23 doi: 10.1007/s00428-022-03277-9. PMID: 35066614
A nomogram for predicting pancreatic mucinous cystic neoplasm and serous cystic neoplasm.
Shao C, Feng X, Yu J, Meng Y, Liu F, Zhang H, Fang X, Li J, Wang L, Jiang H, Lu J, Bian Y
Abdom Radiol (NY) 2021 Aug;46(8):3963-3973. Epub 2021 Mar 22 doi: 10.1007/s00261-021-03038-3. PMID: 33748881
Pancreatic mucinous cystic neoplasm size using CT volumetry, spherical and ellipsoid formulas: validation study.
Chalian H, Seyal AR, Rezai P, Töre HG, Miller FH, Bentrem DJ, Yaghmai V
JOP 2014 Jan 10;15(1):25-32. doi: 10.6092/1590-8577/1893. PMID: 24413780
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

Recent systematic reviews

Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Management of mucinous cystic neoplasms of the pancreas.
Testini M, Gurrado A, Lissidini G, Venezia P, Greco L, Piccinni G
World J Gastroenterol 2010 Dec 7;16(45):5682-92. doi: 10.3748/wjg.v16.i45.5682. PMID: 21128317Free PMC Article

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