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Endometrial hyperplasia without atypia

MedGen UID:
274011
•Concept ID:
C1516855
•
Pathologic Function
Synonyms: Endometrial Hyperplasia without Atypia; endometrial hyperplasia without atypia; Typical Endometrial Hyperplasia; typical endometrial hyperplasia
 
Monarch Initiative: MONDO:0006193

Definition

Simple or complex endometrial hyperplasia characterized by the absence of epithelial atypia. [from NCI]

Professional guidelines

PubMed

Chinese guidelines on the management of endometrial hyperplasia.
Li L, Zhu L; Group for Chinese Guidelines On The Management Of Endometrial Hyperplasia
Eur J Surg Oncol 2024 Jul;50(7):108391. Epub 2024 May 9 doi: 10.1016/j.ejso.2024.108391. PMID: 38735237
Diabetes mellitus and responsiveness of endometrial hyperplasia and early endometrial cancer to conservative treatment.
Raffone A, Travaglino A, Saccone G, Di Maio A, Mollo A, Mascolo M, De Rosa R, De Placido G, Insabato L, Zullo F
Gynecol Endocrinol 2019 Nov;35(11):932-937. Epub 2019 Jun 5 doi: 10.1080/09513590.2019.1624716. PMID: 31165649
PTEN immunohistochemistry in endometrial hyperplasia: which are the optimal criteria for the diagnosis of precancer?
Travaglino A, Raffone A, Saccone G, Mascolo M, Pignatiello S, Mollo A, De Placido G, Insabato L, Zullo F
APMIS 2019 Apr;127(4):161-169. doi: 10.1111/apm.12938. PMID: 30803040

Recent clinical studies

Etiology

D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study.
Porcaro G, Bilotta G, Capoccia E, Bezerra Espinola MS, Aragona C
Int J Mol Sci 2023 Jun 13;24(12) doi: 10.3390/ijms241210080. PMID: 37373229Free PMC Article
Dienogest versus norethisterone acetate in management of endometrial hyperplasia without atypia.
Girbash EF, Sherif HE, Radwan AM, Abdeldayem HM
Arch Gynecol Obstet 2023 Sep;308(3):947-952. Epub 2023 Apr 3 doi: 10.1007/s00404-023-07015-7. PMID: 37010614Free PMC Article
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
Diabetes mellitus and responsiveness of endometrial hyperplasia and early endometrial cancer to conservative treatment.
Raffone A, Travaglino A, Saccone G, Di Maio A, Mollo A, Mascolo M, De Rosa R, De Placido G, Insabato L, Zullo F
Gynecol Endocrinol 2019 Nov;35(11):932-937. Epub 2019 Jun 5 doi: 10.1080/09513590.2019.1624716. PMID: 31165649
Triple negative endometrial cancer.
Bulsa M, Urasińska E
Ginekol Pol 2017;88(4):212-214. doi: 10.5603/GP.a2017.0040. PMID: 28509323

Diagnosis

Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International Endometrial Tumor Analysis study (IETA3).
Heremans R, Van Den Bosch T, Valentin L, Wynants L, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Leone FPG; IETA Consortium
Ultrasound Obstet Gynecol 2022 Aug;60(2):243-255. doi: 10.1002/uog.24910. PMID: 35385178
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
Diabetes mellitus and responsiveness of endometrial hyperplasia and early endometrial cancer to conservative treatment.
Raffone A, Travaglino A, Saccone G, Di Maio A, Mollo A, Mascolo M, De Rosa R, De Placido G, Insabato L, Zullo F
Gynecol Endocrinol 2019 Nov;35(11):932-937. Epub 2019 Jun 5 doi: 10.1080/09513590.2019.1624716. PMID: 31165649
Triple negative endometrial cancer.
Bulsa M, Urasińska E
Ginekol Pol 2017;88(4):212-214. doi: 10.5603/GP.a2017.0040. PMID: 28509323
Endometrial hyperplasia: a review.
Montgomery BE, Daum GS, Dunton CJ
Obstet Gynecol Surv 2004 May;59(5):368-78. doi: 10.1097/00006254-200405000-00025. PMID: 15097798

Therapy

D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study.
Porcaro G, Bilotta G, Capoccia E, Bezerra Espinola MS, Aragona C
Int J Mol Sci 2023 Jun 13;24(12) doi: 10.3390/ijms241210080. PMID: 37373229Free PMC Article
Dienogest versus norethisterone acetate in management of endometrial hyperplasia without atypia.
Girbash EF, Sherif HE, Radwan AM, Abdeldayem HM
Arch Gynecol Obstet 2023 Sep;308(3):947-952. Epub 2023 Apr 3 doi: 10.1007/s00404-023-07015-7. PMID: 37010614Free PMC Article
Survivin Expression in Simple Endometrial Polyps and Tamoxifen-associated Endometrial Polyps.
Gokmen Karasu AF, Sonmez FC, Aydin S, Adanir I, Marasli M, Ilhan GK
Int J Gynecol Pathol 2018 Jan;37(1):27-31. doi: 10.1097/PGP.0000000000000376. PMID: 28319569
Triple negative endometrial cancer.
Bulsa M, Urasińska E
Ginekol Pol 2017;88(4):212-214. doi: 10.5603/GP.a2017.0040. PMID: 28509323
Endometrial hyperplasia: a review.
Montgomery BE, Daum GS, Dunton CJ
Obstet Gynecol Surv 2004 May;59(5):368-78. doi: 10.1097/00006254-200405000-00025. PMID: 15097798

Prognosis

Estimating risk of endometrial malignancy and other intracavitary uterine pathology in women without abnormal uterine bleeding using IETA-1 multinomial regression model: validation study.
Heremans R, Wynants L, Valentin L, Leone FPG, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Van den Bosch T; IETA Consortium
Ultrasound Obstet Gynecol 2024 Apr;63(4):556-563. Epub 2024 Mar 4 doi: 10.1002/uog.27530. PMID: 37927006
Predictive factors of endometrial lesions in patients with abnormal uterine bleeding.
Shang M, Zhang W
Eur J Obstet Gynecol Reprod Biol 2023 Sep;288:67-72. Epub 2023 Jul 11 doi: 10.1016/j.ejogrb.2023.07.002. PMID: 37451131
Human chorionic gonadotropin expression in endometrial hyperplasia and endometrial carcinoma: could it be a new marker?
Daggez M, Dolanbay M, Akgun H, Gülseren V, Keklikcioglu SA, Ozcelik B, Serin IS
Int J Gynecol Cancer 2023 May 1;33(5):707-712. doi: 10.1136/ijgc-2023-004279. PMID: 37001896
Triple negative endometrial cancer.
Bulsa M, Urasińska E
Ginekol Pol 2017;88(4):212-214. doi: 10.5603/GP.a2017.0040. PMID: 28509323
Long-term risk of endometrial cancer following postmenopausal bleeding and reassuring endometrial biopsy.
Visser NC, Sparidaens EM, van den Brink JW, Breijer MC, Boss EA, Veersema S, Siebers AG, Bulten J, Pijnenborg JM, Bekkers RL
Acta Obstet Gynecol Scand 2016 Dec;95(12):1418-1424. Epub 2016 Oct 14 doi: 10.1111/aogs.13022. PMID: 27633936Free PMC Article

Clinical prediction guides

Estimating risk of endometrial malignancy and other intracavitary uterine pathology in women without abnormal uterine bleeding using IETA-1 multinomial regression model: validation study.
Heremans R, Wynants L, Valentin L, Leone FPG, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Van den Bosch T; IETA Consortium
Ultrasound Obstet Gynecol 2024 Apr;63(4):556-563. Epub 2024 Mar 4 doi: 10.1002/uog.27530. PMID: 37927006
Endometrial blood vessel morphometry in patients presenting with abnormal uterine bleeding.
Bhosale NM, Arakeri SU, Reddy AK, Mudanur SR
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):844-850. doi: 10.4103/ijpm.ijpm_89_21. PMID: 36308191
Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International Endometrial Tumor Analysis study (IETA3).
Heremans R, Van Den Bosch T, Valentin L, Wynants L, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Leone FPG; IETA Consortium
Ultrasound Obstet Gynecol 2022 Aug;60(2):243-255. doi: 10.1002/uog.24910. PMID: 35385178
Comparison of nonspecific inflammatory markers in endometrial cancer and hyperplasia.
Alper ECD, Coşkun ADE, Vural F
Rev Assoc Med Bras (1992) 2021 Jul;67(7):966-970. doi: 10.1590/1806-9282.20210318. PMID: 34817507
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286

Recent systematic reviews

Nuclear expression of β-catenin in endometrial hyperplasia as marker of premalignancy.
Travaglino A, Raffone A, Saccone G, Mascolo M, D'Alessandro P, Arduino B, Mollo A, Insabato L, Zullo F
APMIS 2019 Nov;127(11):699-709. Epub 2019 Sep 11 doi: 10.1111/apm.12988. PMID: 31403731
PTEN immunohistochemistry in endometrial hyperplasia: which are the optimal criteria for the diagnosis of precancer?
Travaglino A, Raffone A, Saccone G, Mascolo M, Pignatiello S, Mollo A, De Placido G, Insabato L, Zullo F
APMIS 2019 Apr;127(4):161-169. doi: 10.1111/apm.12938. PMID: 30803040
Loss of PTEN expression as diagnostic marker of endometrial precancer: A systematic review and meta-analysis.
Raffone A, Travaglino A, Saccone G, Campanino MR, Mollo A, De Placido G, Insabato L, Zullo F
Acta Obstet Gynecol Scand 2019 Mar;98(3):275-286. Epub 2019 Jan 6 doi: 10.1111/aogs.13513. PMID: 30511743

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