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inv(14)

MedGen UID:
272936
•Concept ID:
C1515660
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVinv(14)

Professional guidelines

PubMed

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421

Recent clinical studies

Etiology

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
T-Cell Prolymphocytic Leukemia With t(X;14)(q28;q11.2): A Clinicopathologic Study of 15 Cases.
Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rios A, Hu S, Wang W
Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805
Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.
Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, Lopez C, Maria Murga Penas E, Vater I, Jayne S, Dyer MJ, Schrappe M, Dührsen U, Ammerpohl O, Russell RB, Küppers R, Dürig J, Siebert R
Genes Chromosomes Cancer 2014 Apr;53(4):309-16. Epub 2014 Jan 21 doi: 10.1002/gcc.22141. PMID: 24446122
T-cell prolymphocytic leukemia: a single-institution experience.
Ravandi F, O'Brien S, Jones D, Lerner S, Faderl S, Ferrajoli A, Wierda W, Garcia-Manero G, Thomas D, Koller C, Verstovsek S, Giles F, Cortes J, Herling M, Kantarjian H, Keating M
Clin Lymphoma Myeloma 2005 Nov;6(3):234-9. doi: 10.3816/CLM.2005.n.051. PMID: 16354329
Acquired inversions in human leucocytes.
Aurias A, Dutrillaux B
Ann Genet 1986;29(3):203-6. PMID: 3491576

Diagnosis

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
Delineation of clinical course, outcomes, and prognostic factors in patients with T-cell prolymphocytic leukemia.
Rose A, Zhang L, Jain AG, Poovathukaran Babu A, Sokol L, Saeed H, Mo Q, Fan W, Zhang X
Am J Hematol 2023 Jun;98(6):913-921. Epub 2023 Apr 3 doi: 10.1002/ajh.26918. PMID: 36964941
T-Cell Prolymphocytic Leukemia With t(X;14)(q28;q11.2): A Clinicopathologic Study of 15 Cases.
Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rios A, Hu S, Wang W
Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805
Cytogenetic abnormalities in chronic lymphocytic leukemia.
Karnolsky IN
Folia Med (Plovdiv) 2000;42(3):5-10. PMID: 11347338
Acquired inversions in human leucocytes.
Aurias A, Dutrillaux B
Ann Genet 1986;29(3):203-6. PMID: 3491576

Therapy

A Novel JAK2 Fusion in T-Cell Prolymphocytic Leukemia.
Eren OC, Stuver R, Zhou T, Zaidinski M, Moskowitz AJ, Horwitz SM, Ewalt MD, Zhang Y, Lim MS
Genes Chromosomes Cancer 2024 Jun;63(6):e23252. doi: 10.1002/gcc.23252. PMID: 39133763
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, Karran EL, Brown DG, Cain K, Harder L, Gesk S, Martin-Subero JI, Atherton MG, Brüggemann M, Calasanz MJ, Davies T, Haas OA, Hagemeijer A, Kempski H, Lessard M, Lillington DM, Moore S, Nguyen-Khac F, Radford-Weiss I, Schoch C, Struski S, Talley P, Welham MJ, Worley H, Strefford JC, Harrison CJ, Siebert R, Dyer MJ
Blood 2007 Apr 15;109(8):3451-61. Epub 2006 Dec 14 doi: 10.1182/blood-2006-08-041012. PMID: 17170124
Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in pre-B acute lymphoblastic leukemia.
Chervinsky DS, Grossi M, Kakati S, Block AW, Aplan PD
Genes Chromosomes Cancer 1995 Mar;12(3):229-36. doi: 10.1002/gcc.2870120312. PMID: 7536464
Cytogenetic investigations in three cell types of a Saudi family with ataxia telangiectasia.
Waghray M, Gascon GG, al-Sedairy S, Hannan MA
Hum Genet 1991 Jul;87(3):285-9. doi: 10.1007/BF00200905. PMID: 1864602
Clinical and laboratory features of 78 cases of T-prolymphocytic leukemia.
Matutes E, Brito-Babapulle V, Swansbury J, Ellis J, Morilla R, Dearden C, Sempere A, Catovsky D
Blood 1991 Dec 15;78(12):3269-74. PMID: 1742486

Prognosis

A Novel JAK2 Fusion in T-Cell Prolymphocytic Leukemia.
Eren OC, Stuver R, Zhou T, Zaidinski M, Moskowitz AJ, Horwitz SM, Ewalt MD, Zhang Y, Lim MS
Genes Chromosomes Cancer 2024 Jun;63(6):e23252. doi: 10.1002/gcc.23252. PMID: 39133763
Delineation of clinical course, outcomes, and prognostic factors in patients with T-cell prolymphocytic leukemia.
Rose A, Zhang L, Jain AG, Poovathukaran Babu A, Sokol L, Saeed H, Mo Q, Fan W, Zhang X
Am J Hematol 2023 Jun;98(6):913-921. Epub 2023 Apr 3 doi: 10.1002/ajh.26918. PMID: 36964941
Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.
Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, Lopez C, Maria Murga Penas E, Vater I, Jayne S, Dyer MJ, Schrappe M, Dührsen U, Ammerpohl O, Russell RB, Küppers R, Dürig J, Siebert R
Genes Chromosomes Cancer 2014 Apr;53(4):309-16. Epub 2014 Jan 21 doi: 10.1002/gcc.22141. PMID: 24446122
The impact of molecular cytogenetics on chronic lymphoid leukaemia.
Brito-Babapulle V, Garcia-Marco J, Maljaie SH, Hiorns L, Coignet L, Conchon M, Catovsky D
Acta Haematol 1997;98(4):175-86. doi: 10.1159/000203621. PMID: 9401494
Role of chromosomal abnormalities in chronic lymphocytic leukemia.
Gahrton G, Juliusson G, Robèrt KH, Friberg K
Blood Rev 1987 Sep;1(3):183-92. doi: 10.1016/0268-960x(87)90034-8. PMID: 3332102

Clinical prediction guides

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia.
Hu Z, Medeiros LJ, Fang L, Sun Y, Tang Z, Tang G, Sun T, Quesada AE, Hu S, Wang SA, Pei L, Lu X
Am J Hematol 2017 May;92(5):441-447. Epub 2017 Feb 27 doi: 10.1002/ajh.24679. PMID: 28194886
Role of chromosomal abnormalities in chronic lymphocytic leukemia.
Gahrton G, Juliusson G, Robèrt KH, Friberg K
Blood Rev 1987 Sep;1(3):183-92. doi: 10.1016/0268-960x(87)90034-8. PMID: 3332102
New data on clonal anomalies of chromosome 14 in ataxia telangiectasia: tct(14;14) and inv(14).
Aurias A, Croquette MF, Nuyts JP, Griscelli C, Dutrillaux B
Hum Genet 1986 Jan;72(1):22-4. doi: 10.1007/BF00278811. PMID: 3943860
Acquired inversions in human leucocytes.
Aurias A, Dutrillaux B
Ann Genet 1986;29(3):203-6. PMID: 3491576

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