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Intradural extramedullary spinal canal neoplasm

MedGen UID:
272771
•Concept ID:
C1334255
•
Neoplastic Process
Synonyms: Intradural Extramedullary Neoplasm of Spinal Canal; intradural extramedullary neoplasm of spinal canal; Intradural Extramedullary Neoplasm of the Spinal Canal; intradural extramedullary neoplasm of the spinal canal; Intradural Extramedullary Spinal Canal Neoplasm; intradural extramedullary spinal canal neoplasm; Intradural Extramedullary Spinal Canal Tumor; intradural extramedullary spinal canal tumor; Intradural Extramedullary Spinal Canal Tumors; intradural extramedullary spinal canal tumors; intradural extramedullary spinal canal tumour; intradural extramedullary spinal canal tumours; Intradural Extramedullary Spinal Neoplasms; intradural extramedullary spinal neoplasms; Intradural Extramedullary Spinal Tumors; intradural extramedullary spinal tumors; intradural extramedullary spinal tumours; Intradural Extramedullary Tumor of Spinal Canal; intradural extramedullary tumor of spinal canal; Intradural Extramedullary Tumor of the Spinal Canal; intradural extramedullary tumor of the spinal canal; intradural extramedullary tumour of spinal canal; intradural extramedullary tumour of the spinal canal; spinal canal intradural extramedullary neoplasm
 
Monarch Initiative: MONDO:0003545

Definition

A neoplasm that occurs within the spinal canal in the space between the spinal cord and the dura mater. Representative examples include meningioma, neurofibroma, and sarcoma. Signs and symptoms include local and radicular pain, weakness and spinal cord compression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntradural extramedullary spinal canal neoplasm

Professional guidelines

PubMed

Surgical Strategies in the Management of Spinal Nerve Sheath Tumors.
Nanda A, Kukreja S, Ambekar S, Bollam P, Sin AH
World Neurosurg 2015 Jun;83(6):886-99. Epub 2015 Feb 3 doi: 10.1016/j.wneu.2015.01.020. PMID: 25655687
Intramedullary and spinal canal tumors in patients with neurofibromatosis 2: MR imaging findings and correlation with genotype.
Patronas NJ, Courcoutsakis N, Bromley CM, Katzman GL, MacCollin M, Parry DM
Radiology 2001 Feb;218(2):434-42. doi: 10.1148/radiology.218.2.r01fe40434. PMID: 11161159

Recent clinical studies

Etiology

Dural reconstruction following resection of ventral and lateral spinal cord meningiomas: Fenestrated Durotomy with Oversized Graft technique.
Kiyoshi T, Yoshihiro M, Kazuya Y, Kazu K, Hirokazu S, Kenichi K, Yasuharu N
J Clin Neurosci 2023 Oct;116:120-124. Epub 2023 Sep 9 doi: 10.1016/j.jocn.2023.09.003. PMID: 37696149
Intradural Extramedullary Nonconus Nonfilum Spinal Ependymomas: Report of a Rare Variant and Newer Insights into Their Histogenesis with Proposal of a Classification Scheme and a Management Algorithm Based on a Review of Literature.
Das KK, Attri G, Singh S, Bhaisora KS, Verma P, Jaiswal S, Jaiswal A, Behari S
World Neurosurg 2020 Feb;134:323-336. Epub 2019 Nov 1 doi: 10.1016/j.wneu.2019.10.152. PMID: 31682991
Anatomic Basis for Minimally Invasive Resection of Intradural Extramedullary Lesions in Thoracic Spine.
Tumialán LM, Theodore N, Narayanan M, Marciano FF, Nakaji P
World Neurosurg 2018 Jan;109:e770-e777. Epub 2017 Nov 21 doi: 10.1016/j.wneu.2017.10.078. PMID: 29079257
A rare case of intradural and extramedullary epidermoid cyst after repetitive epidural anesthesia: case report and review of the literature.
Funao H, Isogai N, Daimon K, Mima Y, Sugiura H, Koyanagi T, Nakamura M, Matsumoto M, Ishii K
World J Surg Oncol 2017 Jul 17;15(1):131. doi: 10.1186/s12957-017-1186-4. PMID: 28716031Free PMC Article
Anatomical location dictating major surgical complications for intradural extramedullary spinal tumors: a 10-year single-institutional experience.
Mehta AI, Adogwa O, Karikari IO, Thompson P, Verla T, Null UT, Friedman AH, Cheng JS, Bagley CA, Isaacs RE
J Neurosurg Spine 2013 Dec;19(6):701-7. Epub 2013 Oct 11 doi: 10.3171/2013.9.SPINE12913. PMID: 24116680

Diagnosis

Intradural extramedullary spinal choristoma: A case report.
Wu X, Cheng XL, Kang MY, Dong RP, Qu Y, Zhao JW
Medicine (Baltimore) 2023 Dec 15;102(50):e36672. doi: 10.1097/MD.0000000000036672. PMID: 38115260Free PMC Article
Giant intradural extramedullary spinal ependymoma, a rare arachnoiditis-mimicking condition: case report and literature review.
Marchesini N, Soda C, Ricci UM, Pinna G, Alessandrini F, Ghimenton C, Bernasconi R, Paolino G, Teli M
Br J Neurosurg 2023 Aug;37(4):763-768. Epub 2019 Jun 19 doi: 10.1080/02688697.2019.1630551. PMID: 31213094
Meningeal Melanocytoma- A Clinicohistological Masquerader.
Chhabra R, Misra S, Prasad P, Khati S
Neurol India 2022 Sep-Oct;70(5):2153-2155. doi: 10.4103/0028-3886.359256. PMID: 36352627
Primary Spinal Intradural Extramedullary Mesenchymal Chondrosarcoma.
Saito R, Senbokuya N, Yagi T, Yoshioka H, Kanemaru K, Kinouchi H
World Neurosurg 2021 Jan;145:376-380. Epub 2020 Oct 10 doi: 10.1016/j.wneu.2020.10.007. PMID: 33049384
Neoplastic cauda equina syndrome: a neuroimaging-based review.
Bennett SJ, Katzman GL, Roos RP, Mehta AS, Ali S
Pract Neurol 2016 Feb;16(1):35-41. Epub 2015 Oct 6 doi: 10.1136/practneurol-2015-001236. PMID: 26442520

Therapy

Intraspinal epidermoid and dermoid cysts-tumor resection with multimodal intraoperative neurophysiological monitoring and long-term outcome.
Siller S, Egensperger R, Szelenyi A, Tonn JC, Zausinger S, Schichor C
Acta Neurochir (Wien) 2020 Nov;162(11):2895-2903. Epub 2020 Jun 10 doi: 10.1007/s00701-020-04446-y. PMID: 32524245
A rare case of intradural and extramedullary epidermoid cyst after repetitive epidural anesthesia: case report and review of the literature.
Funao H, Isogai N, Daimon K, Mima Y, Sugiura H, Koyanagi T, Nakamura M, Matsumoto M, Ishii K
World J Surg Oncol 2017 Jul 17;15(1):131. doi: 10.1186/s12957-017-1186-4. PMID: 28716031Free PMC Article
Surgery for ventral intradural thoracic spinal tumors with a posterolateral transpedicular approach.
Ito K, Aoyama T, Miyaoka Y, Seguchi T, Horiuchi T, Hongo K
Acta Neurochir (Wien) 2016 Aug;158(8):1563-9. Epub 2016 Jun 11 doi: 10.1007/s00701-016-2864-7. PMID: 27290663
Anatomical location dictating major surgical complications for intradural extramedullary spinal tumors: a 10-year single-institutional experience.
Mehta AI, Adogwa O, Karikari IO, Thompson P, Verla T, Null UT, Friedman AH, Cheng JS, Bagley CA, Isaacs RE
J Neurosurg Spine 2013 Dec;19(6):701-7. Epub 2013 Oct 11 doi: 10.3171/2013.9.SPINE12913. PMID: 24116680
Modified paramedian transpedicular approach and spinal reconstruction for intradural tumors of the cervical and cervicothoracic spine: clinical experience.
Acosta FL Jr, Aryan HE, Chi J, Parsa AT, Ames CP
Spine (Phila Pa 1976) 2007 Mar 15;32(6):E203-10. doi: 10.1097/01.brs.0000257567.91176.76. PMID: 17413461

Prognosis

Meningeal Melanocytoma- A Clinicohistological Masquerader.
Chhabra R, Misra S, Prasad P, Khati S
Neurol India 2022 Sep-Oct;70(5):2153-2155. doi: 10.4103/0028-3886.359256. PMID: 36352627
Lumbar Spinal Epidural Capillary Hemangioma: A Case Report and Literature Review.
Wu S, Sharma KK, Ho CL
Am J Case Rep 2022 Jul 14;23:e936181. doi: 10.12659/AJCR.936181. PMID: 35831983Free PMC Article
Primary Spinal Intradural Extramedullary Mesenchymal Chondrosarcoma.
Saito R, Senbokuya N, Yagi T, Yoshioka H, Kanemaru K, Kinouchi H
World Neurosurg 2021 Jan;145:376-380. Epub 2020 Oct 10 doi: 10.1016/j.wneu.2020.10.007. PMID: 33049384
A rare case of intradural and extramedullary epidermoid cyst after repetitive epidural anesthesia: case report and review of the literature.
Funao H, Isogai N, Daimon K, Mima Y, Sugiura H, Koyanagi T, Nakamura M, Matsumoto M, Ishii K
World J Surg Oncol 2017 Jul 17;15(1):131. doi: 10.1186/s12957-017-1186-4. PMID: 28716031Free PMC Article
Intraspinal Ewing's sarcoma/primitive neuroectodermal tumors.
Yan Y, Xu T, Chen J, Hu G, Lu Y
J Clin Neurosci 2011 May;18(5):601-6. doi: 10.1016/j.jocn.2010.09.012. PMID: 21414790

Clinical prediction guides

Intraspinal epidermoid and dermoid cysts-tumor resection with multimodal intraoperative neurophysiological monitoring and long-term outcome.
Siller S, Egensperger R, Szelenyi A, Tonn JC, Zausinger S, Schichor C
Acta Neurochir (Wien) 2020 Nov;162(11):2895-2903. Epub 2020 Jun 10 doi: 10.1007/s00701-020-04446-y. PMID: 32524245
Cervical Hemilaminoplasty with Miniplates in Long Segment Intradural Extramedullary Ependymoma: Case Report and Technical Note.
Oral S, Tumturk A, Kucuk A, Menku A
Turk Neurosurg 2018;28(1):158-163. doi: 10.5137/1019-5149.JTN.14780-15.2. PMID: 27593777
Two cases of spinal cord extramedullary tumor with positional vertiginous sensation.
Kitahara T, Kondoh K, Kizawa K, Horii A, Kubo T
Acta Otolaryngol Suppl 2009 Jun;(562):50-2. doi: 10.1080/00016480902915673. PMID: 19848240
Spinal tumours in neurofibromatosis type 1: an MRI study of frequency, multiplicity and variety.
Thakkar SD, Feigen U, Mautner VF
Neuroradiology 1999 Sep;41(9):625-9. doi: 10.1007/s002340050814. PMID: 10525761
Spinal tumors in patients with neurofibromatosis type 2: MR imaging study of frequency, multiplicity, and variety.
Mautner VF, Tatagiba M, Lindenau M, Fünsterer C, Pulst SM, Baser ME, Kluwe L, Zanella FE
AJR Am J Roentgenol 1995 Oct;165(4):951-5. doi: 10.2214/ajr.165.4.7676998. PMID: 7676998

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