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Hepatitis B Virus-Related Hepatocellular Carcinoma

MedGen UID:
272708
•Concept ID:
C1333977
•
Neoplastic Process
Synonym: Hepatitis B Virus Related Hepatocellular Carcinoma

Definition

A hepatocellular carcinoma that develops following hepatitis B virus exposure and injury of the liver parenchyma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis B Virus-Related Hepatocellular Carcinoma

Professional guidelines

PubMed

Cost-effectiveness of antiviral treatment after resection in hepatitis B virus-related hepatocellular carcinoma patients with compensated cirrhosis.
Xie L, Yin J, Xia R, Zhuang G
Hepatology 2018 Oct;68(4):1476-1486. Epub 2018 May 14 doi: 10.1002/hep.29922. PMID: 29633304
Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatitis B Virus-Related Hepatocellular Carcinoma Within the Milan Criteria.
Lei Z, Li J, Wu D, Xia Y, Wang Q, Si A, Wang K, Wan X, Lau WY, Wu M, Shen F
JAMA Surg 2016 Apr;151(4):356-63. doi: 10.1001/jamasurg.2015.4257. PMID: 26579636
Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma.
Kubo S, Takemura S, Tanaka S, Shinkawa H, Nishioka T, Nozawa A, Kinoshita M, Hamano G, Ito T, Urata Y
World J Gastroenterol 2015 Jul 21;21(27):8249-55. doi: 10.3748/wjg.v21.i27.8249. PMID: 26217076Free PMC Article

Recent clinical studies

Etiology

Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Neoadjuvant intensity modulated radiotherapy for a single and small (≤5 cm) hepatitis B virus-related hepatocellular carcinoma predicted to have high risks of microvascular invasion: a randomized clinical trial.
Wei X, Jiang Y, Feng S, Lu C, Huo L, Zhou B, Meng Y, Lau WY, Zheng Y, Cheng S
Int J Surg 2023 Oct 1;109(10):3052-3060. doi: 10.1097/JS9.0000000000000574. PMID: 37352528Free PMC Article
Peripheral immune characteristics of hepatitis B virus-related hepatocellular carcinoma.
Sun R, Li J, Lin X, Yang Y, Liu B, Lan T, Xiao S, Deng A, Yin Z, Xu Y, Xiang Z, Wu B
Front Immunol 2023;14:1079495. Epub 2023 Apr 3 doi: 10.3389/fimmu.2023.1079495. PMID: 37077908Free PMC Article
Blood-Based Biomarkers in Hepatitis B Virus-Related Hepatocellular Carcinoma, Including the Viral Genome and Glycosylated Proteins.
Hayashi S, Nagaoka K, Tanaka Y
Int J Mol Sci 2021 Oct 13;22(20) doi: 10.3390/ijms222011051. PMID: 34681709Free PMC Article
Hepatitis B virus-related hepatocellular carcinoma: primary, secondary, and tertiary prevention.
Giacomin A, Cazzagon N, Sergio A, Vanin V, Farinati F
Eur J Cancer Prev 2011 Sep;20(5):381-8. doi: 10.1097/CEJ.0b013e328346399b. PMID: 21540746

Diagnosis

Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Peripheral immune characteristics of hepatitis B virus-related hepatocellular carcinoma.
Sun R, Li J, Lin X, Yang Y, Liu B, Lan T, Xiao S, Deng A, Yin Z, Xu Y, Xiang Z, Wu B
Front Immunol 2023;14:1079495. Epub 2023 Apr 3 doi: 10.3389/fimmu.2023.1079495. PMID: 37077908Free PMC Article
Blood-Based Biomarkers in Hepatitis B Virus-Related Hepatocellular Carcinoma, Including the Viral Genome and Glycosylated Proteins.
Hayashi S, Nagaoka K, Tanaka Y
Int J Mol Sci 2021 Oct 13;22(20) doi: 10.3390/ijms222011051. PMID: 34681709Free PMC Article
Pragmatic tools for the prediction and potential early diagnosis of hepatitis B virus-related hepatocellular carcinoma?
Merle P
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101722. Epub 2021 Jun 16 doi: 10.1016/j.clinre.2021.101722. PMID: 34146725
Resection of hepatitis B virus-related hepatocellular carcinoma: evolving strategies and emerging therapies to improve outcome.
Chau GY
World J Gastroenterol 2014 Sep 21;20(35):12473-84. doi: 10.3748/wjg.v20.i35.12473. PMID: 25253947Free PMC Article

Therapy

Tenofovir versus entecavir on recurrence and mortality of hepatitis B virus-related hepatocellular carcinoma after curative therapy.
Chang KC, Su TH, Liao SH, Tseng TC, Huang SC, Hsu SJ, Hong CM, Liu CH, Yang HC, Liu CJ, Kao JH
J Formos Med Assoc 2024 Aug;123(8):891-898. Epub 2024 Feb 29 doi: 10.1016/j.jfma.2024.02.011. PMID: 38423922
Neoadjuvant intensity modulated radiotherapy for a single and small (≤5 cm) hepatitis B virus-related hepatocellular carcinoma predicted to have high risks of microvascular invasion: a randomized clinical trial.
Wei X, Jiang Y, Feng S, Lu C, Huo L, Zhou B, Meng Y, Lau WY, Zheng Y, Cheng S
Int J Surg 2023 Oct 1;109(10):3052-3060. doi: 10.1097/JS9.0000000000000574. PMID: 37352528Free PMC Article
Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy.
Kim BK, Ahn SH
J Formos Med Assoc 2023 Dec;122(12):1238-1246. Epub 2023 Jun 15 doi: 10.1016/j.jfma.2023.05.029. PMID: 37330305
Hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy: The emerging role of non-viral risk factors.
Li W, Deng R, Liu S, Wang K, Sun J
Liver Int 2020 Oct;40(10):2316-2325. Epub 2020 Aug 3 doi: 10.1111/liv.14607. PMID: 32666675
Hepatitis B virus-related hepatocellular carcinoma: primary, secondary, and tertiary prevention.
Giacomin A, Cazzagon N, Sergio A, Vanin V, Farinati F
Eur J Cancer Prev 2011 Sep;20(5):381-8. doi: 10.1097/CEJ.0b013e328346399b. PMID: 21540746

Prognosis

Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Neoadjuvant intensity modulated radiotherapy for a single and small (≤5 cm) hepatitis B virus-related hepatocellular carcinoma predicted to have high risks of microvascular invasion: a randomized clinical trial.
Wei X, Jiang Y, Feng S, Lu C, Huo L, Zhou B, Meng Y, Lau WY, Zheng Y, Cheng S
Int J Surg 2023 Oct 1;109(10):3052-3060. doi: 10.1097/JS9.0000000000000574. PMID: 37352528Free PMC Article
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Pragmatic tools for the prediction and potential early diagnosis of hepatitis B virus-related hepatocellular carcinoma?
Merle P
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101722. Epub 2021 Jun 16 doi: 10.1016/j.clinre.2021.101722. PMID: 34146725
Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma.
Han YF, Zhao J, Ma LY, Yin JH, Chang WJ, Zhang HW, Cao GW
World J Gastroenterol 2011 Oct 14;17(38):4258-70. doi: 10.3748/wjg.v17.i38.4258. PMID: 22090781Free PMC Article

Clinical prediction guides

Hepatitis B virus-related hepatocellular carcinoma exhibits distinct intratumoral microbiota and immune microenvironment signatures.
Liu Y, Kim ES, Guo H
J Med Virol 2024 Feb;96(2):e29485. doi: 10.1002/jmv.29485. PMID: 38377167Free PMC Article
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Neoadjuvant intensity modulated radiotherapy for a single and small (≤5 cm) hepatitis B virus-related hepatocellular carcinoma predicted to have high risks of microvascular invasion: a randomized clinical trial.
Wei X, Jiang Y, Feng S, Lu C, Huo L, Zhou B, Meng Y, Lau WY, Zheng Y, Cheng S
Int J Surg 2023 Oct 1;109(10):3052-3060. doi: 10.1097/JS9.0000000000000574. PMID: 37352528Free PMC Article
Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy.
Kim BK, Ahn SH
J Formos Med Assoc 2023 Dec;122(12):1238-1246. Epub 2023 Jun 15 doi: 10.1016/j.jfma.2023.05.029. PMID: 37330305
Pragmatic tools for the prediction and potential early diagnosis of hepatitis B virus-related hepatocellular carcinoma?
Merle P
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101722. Epub 2021 Jun 16 doi: 10.1016/j.clinre.2021.101722. PMID: 34146725

Recent systematic reviews

Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Preoperative antiviral therapy and microvascular invasion in hepatitis B virus-related hepatocellular carcinoma: A meta-analysis.
Wang Z, Duan Y, Zhang J, Lv Y, Wu S, Cheng M, Bhagavathula AS, Aldhaleei WA, Clark C, Huo Z
Eur J Pharmacol 2020 Sep 15;883:173382. Epub 2020 Jul 18 doi: 10.1016/j.ejphar.2020.173382. PMID: 32693099
Effect of adjuvant interferon therapy on hepatitis B virus-related hepatocellular carcinoma: a systematic review.
Yang S, Lin Q, Lin W, Hu W, Wang G
World J Surg Oncol 2016 Jun 9;14(1):159. doi: 10.1186/s12957-016-0912-7. PMID: 27282382Free PMC Article
Efficacy of antiviral therapy with nucleotide/nucleoside analogs after curative treatment for patients with hepatitis B virus-related hepatocellular carcinoma: A systematic review and meta-analysis.
Xia BW, Zhang YC, Wang J, Ding FH, He XD
Clin Res Hepatol Gastroenterol 2015 Sep;39(4):458-68. Epub 2015 Jan 28 doi: 10.1016/j.clinre.2014.12.003. PMID: 25650304
Nucleot(s)ide analogues for hepatitis B virus-related hepatocellular carcinoma after curative treatment: a systematic review and meta-analysis.
Sun P, Dong X, Cheng X, Hu Q, Zheng Q
PLoS One 2014;9(7):e102761. Epub 2014 Jul 24 doi: 10.1371/journal.pone.0102761. PMID: 25058587Free PMC Article

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