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DNA Intrastrand Crosslinking

MedGen UID:
268317
•Concept ID:
C1511675
•
Cell or Molecular Dysfunction

Definition

DNA Intrastrand Crosslinking involves the formation of a covalent bond between two bases on the same DNA strand. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Intrastrand Crosslinking

Professional guidelines

PubMed

Schedule-Dependent Treatment Increases Chemotherapy Efficacy in Malignant Pleural Mesothelioma.
Karatkevich D, Deng H, Gao Y, Flint E, Peng RW, Schmid RA, Dorn P, Marti TM
Int J Mol Sci 2022 Oct 8;23(19) doi: 10.3390/ijms231911949. PMID: 36233258Free PMC Article
Third row transition metals for the treatment of cancer.
Johnstone TC, Suntharalingam K, Lippard SJ
Philos Trans A Math Phys Eng Sci 2015 Mar 13;373(2037) doi: 10.1098/rsta.2014.0185. PMID: 25666060Free PMC Article
DNA repair pathways and their implication in cancer treatment.
Pallis AG, Karamouzis MV
Cancer Metastasis Rev 2010 Dec;29(4):677-85. doi: 10.1007/s10555-010-9258-8. PMID: 20821251

Recent clinical studies

Etiology

Acetaldehyde induces NER repairable mutagenic DNA lesions.
Sonohara Y, Takatsuka R, Masutani C, Iwai S, Kuraoka I
Carcinogenesis 2022 Feb 11;43(1):52-59. doi: 10.1093/carcin/bgab087. PMID: 34546339
Clinical Perspectives of ERCC1 in Bladder Cancer.
Koutsoukos K, Andrikopoulou A, Dedes N, Zagouri F, Bamias A, Dimopoulos MA
Int J Mol Sci 2020 Nov 22;21(22) doi: 10.3390/ijms21228829. PMID: 33266377Free PMC Article
Detection of UV-Induced Thymine Dimers.
Yadav VK, Awasthi P, Kumar A
Methods Mol Biol 2019;2031:313-322. doi: 10.1007/978-1-4939-9646-9_17. PMID: 31473968
Removal of oxidatively generated DNA damage by overlapping repair pathways.
Shafirovich V, Geacintov NE
Free Radic Biol Med 2017 Jun;107:53-61. Epub 2016 Nov 4 doi: 10.1016/j.freeradbiomed.2016.10.507. PMID: 27818219Free PMC Article
Chronic inflammation and mutagenesis.
Ferguson LR
Mutat Res 2010 Aug 7;690(1-2):3-11. Epub 2010 Mar 17 doi: 10.1016/j.mrfmmm.2010.03.007. PMID: 20223251

Diagnosis

Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging.
Rieckher M, Gallrein C, Alquezar-Artieda N, Bourached-Silva N, Vaddavalli PL, Mares D, Backhaus M, Blindauer T, Greger K, Wiesner E, Pontel LB, Schumacher B
Nucleic Acids Res 2024 Aug 12;52(14):8271-8285. doi: 10.1093/nar/gkae519. PMID: 38894680Free PMC Article
Clinical Perspectives of ERCC1 in Bladder Cancer.
Koutsoukos K, Andrikopoulou A, Dedes N, Zagouri F, Bamias A, Dimopoulos MA
Int J Mol Sci 2020 Nov 22;21(22) doi: 10.3390/ijms21228829. PMID: 33266377Free PMC Article
Neurotoxicity Associated with Platinum-Based Anti-Cancer Agents: What are the Implications of Copper Transporters?
Stojanovska V, McQuade R, Rybalka E, Nurgali K
Curr Med Chem 2017;24(15):1520-1536. doi: 10.2174/0929867324666170112095428. PMID: 28079002
Differential DNA lesion formation and repair in heterochromatin and euchromatin.
Han C, Srivastava AK, Cui T, Wang QE, Wani AA
Carcinogenesis 2016 Feb;37(2):129-38. Epub 2015 Dec 30 doi: 10.1093/carcin/bgv247. PMID: 26717995Free PMC Article
DNA polymerase eta, a key protein in translesion synthesis in human cells.
Cruet-Hennequart S, Gallagher K, Sokòl AM, Villalan S, Prendergast AM, Carty MP
Subcell Biochem 2010;50:189-209. doi: 10.1007/978-90-481-3471-7_10. PMID: 20012583

Therapy

Revisiting the Anti-Cancer Toxicity of Clinically Approved Platinating Derivatives.
Forgie BN, Prakash R, Telleria CM
Int J Mol Sci 2022 Dec 6;23(23) doi: 10.3390/ijms232315410. PMID: 36499737Free PMC Article
Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted.
Ali R, Aouida M, Alhaj Sulaiman A, Madhusudan S, Ramotar D
Int J Mol Sci 2022 Jun 29;23(13) doi: 10.3390/ijms23137241. PMID: 35806243Free PMC Article
Clinical Perspectives of ERCC1 in Bladder Cancer.
Koutsoukos K, Andrikopoulou A, Dedes N, Zagouri F, Bamias A, Dimopoulos MA
Int J Mol Sci 2020 Nov 22;21(22) doi: 10.3390/ijms21228829. PMID: 33266377Free PMC Article
Detection of UV-Induced Thymine Dimers.
Yadav VK, Awasthi P, Kumar A
Methods Mol Biol 2019;2031:313-322. doi: 10.1007/978-1-4939-9646-9_17. PMID: 31473968
Advances in therapeutic targeting of the DNA damage response in cancer.
Desai A, Yan Y, Gerson SL
DNA Repair (Amst) 2018 Jun-Jul;66-67:24-29. Epub 2018 Apr 23 doi: 10.1016/j.dnarep.2018.04.004. PMID: 29715575Free PMC Article

Prognosis

Clinical Perspectives of ERCC1 in Bladder Cancer.
Koutsoukos K, Andrikopoulou A, Dedes N, Zagouri F, Bamias A, Dimopoulos MA
Int J Mol Sci 2020 Nov 22;21(22) doi: 10.3390/ijms21228829. PMID: 33266377Free PMC Article
Pharmacogenetics of platinum-based chemotherapy in non-small cell lung cancer: predictive validity of polymorphisms of ERCC1.
Hamilton G, Rath B
Expert Opin Drug Metab Toxicol 2018 Jan;14(1):17-24. Epub 2017 Dec 18 doi: 10.1080/17425255.2018.1416095. PMID: 29226731
Expression of DNA double-strand break repair proteins predicts the response and prognosis of colorectal cancer patients undergoing oxaliplatin-based chemotherapy.
Ihara K, Yamaguchi S, Ueno N, Tani Y, Shida Y, Ogata H, Domeki Y, Okamoto K, Nakajima M, Sasaki K, Tsuchioka T, Mitomi H, Kato H
Oncol Rep 2016 Mar;35(3):1349-55. Epub 2015 Dec 16 doi: 10.3892/or.2015.4488. PMID: 26676960
DNA repair pathways and their implication in cancer treatment.
Pallis AG, Karamouzis MV
Cancer Metastasis Rev 2010 Dec;29(4):677-85. doi: 10.1007/s10555-010-9258-8. PMID: 20821251
DNA adducts from chemotherapeutic agents.
Lawley PD, Phillips DH
Mutat Res 1996 Aug 17;355(1-2):13-40. doi: 10.1016/0027-5107(96)00020-6. PMID: 8781575

Clinical prediction guides

Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer.
Luong TT, Li Z, Priedigkeit N, Parker PS, Böhm S, Rapchak K, Lee AV, Bernstein KA
PLoS Genet 2022 Sep;18(9):e1010122. Epub 2022 Sep 20 doi: 10.1371/journal.pgen.1010122. PMID: 36126066Free PMC Article
Acetaldehyde induces NER repairable mutagenic DNA lesions.
Sonohara Y, Takatsuka R, Masutani C, Iwai S, Kuraoka I
Carcinogenesis 2022 Feb 11;43(1):52-59. doi: 10.1093/carcin/bgab087. PMID: 34546339
Clinical Perspectives of ERCC1 in Bladder Cancer.
Koutsoukos K, Andrikopoulou A, Dedes N, Zagouri F, Bamias A, Dimopoulos MA
Int J Mol Sci 2020 Nov 22;21(22) doi: 10.3390/ijms21228829. PMID: 33266377Free PMC Article
DNA Distortion Caused by Uracil-Containing Intrastrand Cross-Links.
Churchill CD, Eriksson LA, Wetmore SD
J Phys Chem B 2016 Feb 25;120(7):1195-204. Epub 2016 Feb 15 doi: 10.1021/acs.jpcb.5b10381. PMID: 26830475
DNA repair pathways and their implication in cancer treatment.
Pallis AG, Karamouzis MV
Cancer Metastasis Rev 2010 Dec;29(4):677-85. doi: 10.1007/s10555-010-9258-8. PMID: 20821251

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