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Deceptive Imprinting

MedGen UID:
268014
•Concept ID:
C1511739
•
Cell or Molecular Dysfunction

Definition

Refers to a mechanism leading to a fixed state of immunity that fails to adapt to a changing pathogen and has lost the ability to discriminate antigen after the establishment of a strong primary immune response. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeceptive Imprinting

Recent clinical studies

Etiology

Heterotypic humoral and cellular immune responses following Norwalk virus infection.
Lindesmith LC, Donaldson E, Leon J, Moe CL, Frelinger JA, Johnston RE, Weber DJ, Baric RS
J Virol 2010 Feb;84(4):1800-15. Epub 2009 Dec 9 doi: 10.1128/JVI.02179-09. PMID: 20007270Free PMC Article

Therapy

Novel vaccine concept based on back-boost effect in viral infection.
Kohler H
Vaccine 2015 Jun 26;33(29):3274-5. Epub 2015 May 30 doi: 10.1016/j.vaccine.2015.05.035. PMID: 26032350
Safety and ethical consideration of AIDS vaccine.
Veljkovic V, Prljic J, Veljkovic T
Int Rev Immunol 2004 Sep-Dec;23(5-6):465-86. doi: 10.1080/08830180490432866. PMID: 15370278

Clinical prediction guides

Deceptive imprinting and immune refocusing in vaccine design.
Tobin GJ, Trujillo JD, Bushnell RV, Lin G, Chaudhuri AR, Long J, Barrera J, Pena L, Grubman MJ, Nara PL
Vaccine 2008 Nov 18;26(49):6189-99. Epub 2008 Oct 11 doi: 10.1016/j.vaccine.2008.09.080. PMID: 18852005

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