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Breast Carcinoma with Melanotic Features

MedGen UID:
267906
•Concept ID:
C1511303
•
Neoplastic Process

Definition

A very rare primary malignant tumor of the breast, characterized by an invasive breast carcinoma that co-exists with a melanoma component. The vast majority of melanotic tumors that affect the breast are metastatic melanomas that originate in extra-mammary sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma with Melanotic Features

Recent clinical studies

Etiology

A subgroup of melanocytic nevi on the distal lower extremity (ankle) shares features of acral nevi, dysplastic nevi, and melanoma in situ: a potential misdiagnosis of melanoma in situ.
Khalifeh I, Taraif S, Reed JA, Lazar AF, Diwan AH, Prieto VG
Am J Surg Pathol 2007 Jul;31(7):1130-6. doi: 10.1097/PAS.0b013e31802e63a2. PMID: 17592281
Association of Peutz-Jeghers-like mucocutaneous pigmentation with breast and gynecologic carcinomas in women.
Boardman LA, Pittelkow MR, Couch FJ, Schaid DJ, McDonnell SK, Burgart LJ, Ahlquist DA, Carney JA, Schwartz DI, Thibodeau SN, Hartmann LC
Medicine (Baltimore) 2000 Sep;79(5):293-8. doi: 10.1097/00005792-200009000-00002. PMID: 11039077
Myxoid fibroadenoma and allied conditions (myxomatosis) of the breast. A heritable disorder with special associations including cardiac and cutaneous myxomas.
Carney JA, Toorkey BC
Am J Surg Pathol 1991 Aug;15(8):713-21. doi: 10.1097/00000478-199108000-00001. PMID: 2069209

Diagnosis

Melanotic nonpsammomatous trigeminal schwannoma as the first manifestation of Carney complex: case report.
Carrasco CA, Rojas-Salazar D, Chiorino R, Venega JC, Wohllk N
Neurosurgery 2006 Dec;59(6):E1334-5; discussion E1335. doi: 10.1227/01.NEU.0000245608.07570.D2. PMID: 17277668
Rare syndromes.
Jabbour SA, Davidovici BB, Wolf R
Clin Dermatol 2006 Jul-Aug;24(4):299-316. doi: 10.1016/j.clindermatol.2006.04.005. PMID: 16828412
Association of Peutz-Jeghers-like mucocutaneous pigmentation with breast and gynecologic carcinomas in women.
Boardman LA, Pittelkow MR, Couch FJ, Schaid DJ, McDonnell SK, Burgart LJ, Ahlquist DA, Carney JA, Schwartz DI, Thibodeau SN, Hartmann LC
Medicine (Baltimore) 2000 Sep;79(5):293-8. doi: 10.1097/00005792-200009000-00002. PMID: 11039077
A case of amelanotic spindle-cell melanoma presenting as metastases to breast and axillary lymph node: diagnosis by FNA cytology.
Kobayashi G, Cobb C
Diagn Cytopathol 2000 Apr;22(4):246-9. doi: 10.1002/(sici)1097-0339(200004)22:4<246::aid-dc10>3.0.co;2-q. PMID: 10787147
Familial endocrine myxolentiginosis.
Panossian DH, Marais GE, Marais HJ
Clin Cardiol 1995 Nov;18(11):675-8. doi: 10.1002/clc.4960181116. PMID: 8590539

Clinical prediction guides

A case of amelanotic spindle-cell melanoma presenting as metastases to breast and axillary lymph node: diagnosis by FNA cytology.
Kobayashi G, Cobb C
Diagn Cytopathol 2000 Apr;22(4):246-9. doi: 10.1002/(sici)1097-0339(200004)22:4<246::aid-dc10>3.0.co;2-q. PMID: 10787147

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