U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast Inflammatory Myofibroblastic Tumor

MedGen UID:
267767
•Concept ID:
C1511315
•
Neoplastic Process

Definition

A multinodular intermediate fibroblastic neoplasm arising from the breast. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Inflammatory Myofibroblastic Tumor

Professional guidelines

PubMed

Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response.
Kang K, Wu Y, Han C, Wang L, Wang Z, Zhao A
Comput Biol Med 2023 May;158:106836. Epub 2023 Mar 29 doi: 10.1016/j.compbiomed.2023.106836. PMID: 37031511
Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast.
Liu S, Yuan R, Jin Y, He C, Zheng X, Zhan Y
Breast J 2022;2022:1863123. Epub 2022 Aug 12 doi: 10.1155/2022/1863123. PMID: 36304484Free PMC Article
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Tothova Z, Wagner AJ
Curr Opin Oncol 2012 Jul;24(4):409-13. doi: 10.1097/CCO.0b013e328354c155. PMID: 22664824

Diagnosis

Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast.
Liu S, Yuan R, Jin Y, He C, Zheng X, Zhan Y
Breast J 2022;2022:1863123. Epub 2022 Aug 12 doi: 10.1155/2022/1863123. PMID: 36304484Free PMC Article
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
IgG4-related disease.
Hirabayashi K, Zamboni G
Pathologica 2012 Apr;104(2):43-55. PMID: 22953500

Therapy

Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Impact of ALK Inhibitors in Patients With ALK-Rearranged Nonlung Solid Tumors.
Takeyasu Y, Okuma HS, Kojima Y, Nishikawa T, Tanioka M, Sudo K, Shimoi T, Noguchi E, Arakawa A, Mori T, Sunami K, Kubo T, Kohno T, Akihiko Y, Yamamoto N, Yonemori K
JCO Precis Oncol 2021;5 Epub 2021 May 3 doi: 10.1200/PO.20.00383. PMID: 34036223Free PMC Article
ALK-positive Histiocytosis of the Breast: A Clinicopathologic Study Highlighting Spindle Cell Histology.
Kashima J, Yoshida M, Jimbo K, Izutsu K, Ushiku T, Yonemori K, Yoshida A
Am J Surg Pathol 2021 Mar 1;45(3):347-355. doi: 10.1097/PAS.0000000000001567. PMID: 32826530
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Tothova Z, Wagner AJ
Curr Opin Oncol 2012 Jul;24(4):409-13. doi: 10.1097/CCO.0b013e328354c155. PMID: 22664824

Prognosis

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Single-cell RNA sequencing reveals the MIF-ACKR3 receptor-ligand interaction between iCAFs and tumor cells in esophageal squamous cell carcinoma.
Liang J, Lei K, Liang R, Huang J, Tan B, Lin H, Wang M
Cell Signal 2024 May;117:111093. Epub 2024 Feb 7 doi: 10.1016/j.cellsig.2024.111093. PMID: 38336189
Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response.
Kang K, Wu Y, Han C, Wang L, Wang Z, Zhao A
Comput Biol Med 2023 May;158:106836. Epub 2023 Mar 29 doi: 10.1016/j.compbiomed.2023.106836. PMID: 37031511
Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104

Clinical prediction guides

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response.
Kang K, Wu Y, Han C, Wang L, Wang Z, Zhao A
Comput Biol Med 2023 May;158:106836. Epub 2023 Mar 29 doi: 10.1016/j.compbiomed.2023.106836. PMID: 37031511
Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts.
Andreucci E, Fioretto BS, Rosa I, Matucci-Cerinic M, Biagioni A, Romano E, Calorini L, Manetti M
Cells 2023 Mar 20;12(6) doi: 10.3390/cells12060939. PMID: 36980280Free PMC Article
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...