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Infant gynecomastia

MedGen UID:
258541
Concept ID:
C1449721
Disease or Syndrome
Synonyms: Gynecomastia, Infant; Gynecomastia, Newborn; Infant Gynecomastia; Newborn Gynecomastia
SNOMED CT: Breast engorgement of new born (34831003); Neonatal gynecomastia (34831003); Breast engorgement in newborn (34831003)
 
Monarch Initiative: MONDO:0001323

Definition

Transient bilateral swelling of breast tissue in a neonate that results from the waning influence of maternal estrogen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant gynecomastia

Professional guidelines

PubMed

Khan NAJ, Tirona M
Med Oncol 2021 Mar 15;38(4):39. doi: 10.1007/s12032-021-01486-x. PMID: 33721121
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Rahnema CD, Lipshultz LI, Crosnoe LE, Kovac JR, Kim ED
Fertil Steril 2014 May;101(5):1271-9. Epub 2014 Mar 14 doi: 10.1016/j.fertnstert.2014.02.002. PMID: 24636400

Recent clinical studies

Etiology

McCoskey M, Vernon N
Prim Care 2024 Sep;51(3):455-466. Epub 2024 May 23 doi: 10.1016/j.pop.2024.04.003. PMID: 39067971
Ayyavoo A
Indian J Pediatr 2023 Oct;90(10):1013-1017. Epub 2023 Aug 18 doi: 10.1007/s12098-023-04810-7. PMID: 37592101
Horwitz H, Andersen JT, Dalhoff KP
J Intern Med 2019 Mar;285(3):333-340. Epub 2018 Nov 20 doi: 10.1111/joim.12850. PMID: 30460728
Nguyen PL, Alibhai SM, Basaria S, D'Amico AV, Kantoff PW, Keating NL, Penson DF, Rosario DJ, Tombal B, Smith MR
Eur Urol 2015 May;67(5):825-36. Epub 2014 Aug 2 doi: 10.1016/j.eururo.2014.07.010. PMID: 25097095
Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J
N Engl J Med 1999 Sep 2;341(10):709-17. doi: 10.1056/NEJM199909023411001. PMID: 10471456

Diagnosis

Ayyavoo A
Indian J Pediatr 2023 Oct;90(10):1013-1017. Epub 2023 Aug 18 doi: 10.1007/s12098-023-04810-7. PMID: 37592101
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Guss CE, Divasta AD
Pediatr Endocrinol Rev 2017 Jun;14(4):371-377. doi: 10.17458/per.vol14.2017.GD.Gynecomastia. PMID: 28613047
Sansone A, Romanelli F, Sansone M, Lenzi A, Di Luigi L
Endocrine 2017 Jan;55(1):37-44. Epub 2016 May 4 doi: 10.1007/s12020-016-0975-9. PMID: 27145756
Dickson G
Am Fam Physician 2012 Apr 1;85(7):716-22. PMID: 22534349

Therapy

Ayyavoo A
Indian J Pediatr 2023 Oct;90(10):1013-1017. Epub 2023 Aug 18 doi: 10.1007/s12098-023-04810-7. PMID: 37592101
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Sansone A, Romanelli F, Sansone M, Lenzi A, Di Luigi L
Endocrine 2017 Jan;55(1):37-44. Epub 2016 May 4 doi: 10.1007/s12020-016-0975-9. PMID: 27145756
Wibowo E, Pollock PA, Hollis N, Wassersug RJ
Andrology 2016 Sep;4(5):776-88. Epub 2016 May 6 doi: 10.1111/andr.12197. PMID: 27152880
Deepinder F, Braunstein GD
Expert Opin Drug Saf 2012 Sep;11(5):779-95. Epub 2012 Aug 6 doi: 10.1517/14740338.2012.712109. PMID: 22862307

Prognosis

Sá R, Ferraz L, Barros A, Sousa M
Genes (Basel) 2023 Mar 4;14(3) doi: 10.3390/genes14030647. PMID: 36980920Free PMC Article
Khan NAJ, Tirona M
Med Oncol 2021 Mar 15;38(4):39. doi: 10.1007/s12032-021-01486-x. PMID: 33721121
Horwitz H, Andersen JT, Dalhoff KP
J Intern Med 2019 Mar;285(3):333-340. Epub 2018 Nov 20 doi: 10.1111/joim.12850. PMID: 30460728
Deepinder F, Braunstein GD
Expert Opin Drug Saf 2012 Sep;11(5):779-95. Epub 2012 Aug 6 doi: 10.1517/14740338.2012.712109. PMID: 22862307
Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J
N Engl J Med 1999 Sep 2;341(10):709-17. doi: 10.1056/NEJM199909023411001. PMID: 10471456

Clinical prediction guides

Sá R, Ferraz L, Barros A, Sousa M
Genes (Basel) 2023 Mar 4;14(3) doi: 10.3390/genes14030647. PMID: 36980920Free PMC Article
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Khan NAJ, Tirona M
Med Oncol 2021 Mar 15;38(4):39. doi: 10.1007/s12032-021-01486-x. PMID: 33721121
Sansone A, Romanelli F, Sansone M, Lenzi A, Di Luigi L
Endocrine 2017 Jan;55(1):37-44. Epub 2016 May 4 doi: 10.1007/s12020-016-0975-9. PMID: 27145756
Nguyen PL, Alibhai SM, Basaria S, D'Amico AV, Kantoff PW, Keating NL, Penson DF, Rosario DJ, Tombal B, Smith MR
Eur Urol 2015 May;67(5):825-36. Epub 2014 Aug 2 doi: 10.1016/j.eururo.2014.07.010. PMID: 25097095

Recent systematic reviews

Singh AK, Singh A, Singh R, Misra A
Diabetes Metab Syndr 2022 Oct;16(10):102638. Epub 2022 Oct 4 doi: 10.1016/j.dsx.2022.102638. PMID: 36223666
Trinchieri A, Perletti G, Magri V, Stamatiou K, Trinchieri M, Montanari E
Arch Ital Urol Androl 2021 Dec 21;93(4):489-496. doi: 10.4081/aiua.2021.4.489. PMID: 34933535
Patanè FG, Liberto A, Maria Maglitto AN, Malandrino P, Esposito M, Amico F, Cocimano G, Rosi GL, Condorelli D, Nunno ND, Montana A
Medicina (Kaunas) 2020 Nov 11;56(11) doi: 10.3390/medicina56110606. PMID: 33187340Free PMC Article
Christou MA, Christou PA, Markozannes G, Tsatsoulis A, Mastorakos G, Tigas S
Sports Med 2017 Sep;47(9):1869-1883. doi: 10.1007/s40279-017-0709-z. PMID: 28258581
Fagerlund A, Lewin R, Rufolo G, Elander A, Santanelli di Pompeo F, Selvaggi G
J Plast Surg Hand Surg 2015;49(6):311-8. Epub 2015 Jun 7 doi: 10.3109/2000656X.2015.1053398. PMID: 26051284

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