U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Deep dermatophytosis

MedGen UID:
235599
•Concept ID:
C1395264
•
Disease or Syndrome
Synonyms: deep seated dermatophytosis; Granuloma trichophyticum
SNOMED CT: Deep seated dermatophytosis (266152000); Granuloma trichophyticum (266152000); Dermatophytic mycetoma (266152000); Dermatophytosis profunda (266152000); Dermatophytic granuloma (266152000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0032515
Monarch Initiative: MONDO:0021660
Orphanet: ORPHA397587

Definition

A type of invasive dermatophyte infection of the deep dermis characterized by extensive dermal infiltration by fungal elements. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeep dermatophytosis

Conditions with this feature

Predisposition to invasive fungal disease due to CARD9 deficiency
MedGen UID:
347128
•Concept ID:
C1859353
•
Disease or Syndrome
A rare genetic primary immunodeficiency with characteristics of increased susceptibility to fungal infections that typically manifest as recurrent, chronic mucocutaneous candidiasis, systemic candidiasis with meningoencephalitis and deep dermatophytosis. Dermatophytes invade skin, hair, nails, lymph nodes and brain, resulting in erythematosquamous lesions, nodular subcutaneous or ulcerative infiltrations, severe onychomycosis and lymphadenopathy.
See: Condition Record
Predisposition to invasive fungal disease due to CARD9 deficiency

Professional guidelines

PubMed

Prior selection of itraconazole in the treatment of recalcitrant Trichophyton indotineae infection: Real-world results from retrospective analysis.
Song G, Kong X, Li X, Liu W, Liang G
Mycoses 2024 Jan;67(1):e13663. Epub 2023 Oct 26 doi: 10.1111/myc.13663. PMID: 37882456
Management of a Trichophyton tonsurans outbreak in a day-care center.
Gray RM, Champagne C, Waghorn D, Ong E, Grabczynska SA, Morris J
Pediatr Dermatol 2015 Jan-Feb;32(1):91-6. Epub 2014 Sep 25 doi: 10.1111/pde.12421. PMID: 25257708
Onychomycosis: modern diagnostic and treatment approaches.
Tchernev G, Penev PK, Nenoff P, Zisova LG, Cardoso JC, Taneva T, Ginter-Hanselmayer G, Ananiev J, Gulubova M, Hristova R, Nocheva D, Guarneri C, Martino G, Kanazawa N
Wien Med Wochenschr 2013 Jan;163(1-2):1-12. Epub 2012 Sep 30 doi: 10.1007/s10354-012-0139-3. PMID: 23053563

Recent clinical studies

Etiology

Severe dermatophytosis in solid organ transplant recipients: A French retrospective series and literature review.
Rouzaud C, Chosidow O, Brocard A, Fraitag S, Scemla A, Anglicheau D, Bouaziz JD, Dupin N, Bougnoux ME, Hay R, Lortholary O, Lanternier F; French Mycoses Study Group
Transpl Infect Dis 2018 Feb;20(1) Epub 2018 Jan 25 doi: 10.1111/tid.12799. PMID: 29094463
A Unique Clinicopathological Manifestation of Fungal Infection: A Case Series of Deep Dermatophytosis in Immunosuppressed Patients.
Kershenovich R, Sherman S, Reiter O, Huss SR, Didkovsky E, Mimouni D, Hodak E, Segal R
Am J Clin Dermatol 2017 Oct;18(5):697-704. doi: 10.1007/s40257-017-0276-y. PMID: 28389891
New clinical phenotypes of fungal infections in special hosts.
Pilmis B, Puel A, Lortholary O, Lanternier F
Clin Microbiol Infect 2016 Aug;22(8):681-7. Epub 2016 May 26 doi: 10.1016/j.cmi.2016.05.016. PMID: 27237547
Kerion of the vulva caused by Trichophyton mentagrophytes.
Bougrine A, Villeneuve-Tang C, Bouffard D, Rouleau D, Chartier S
J Cutan Med Surg 2014 May-Jun;18(3):206-9. doi: 10.2310/7750.2013.13101. PMID: 24800711
Primary immunodeficiencies underlying fungal infections.
Lanternier F, Cypowyj S, Picard C, Bustamante J, Lortholary O, Casanova JL, Puel A
Curr Opin Pediatr 2013 Dec;25(6):736-47. doi: 10.1097/MOP.0000000000000031. PMID: 24240293Free PMC Article

Diagnosis

Deep dermatophytosis caused by Trichophyton rubrum in an elderly patient with CARD9 deficiency: A case report and literature review.
Ansai O, Hayashi R, Nakamura A, Sasaki J, Hasegawa A, Deguchi T, Yuki A, Oike N, Ariizumi T, Abe M, Miyazaki Y, Takenouchi T, Kawashima H, Abe R
J Dermatol 2024 Feb;51(2):294-300. Epub 2023 Oct 7 doi: 10.1111/1346-8138.16995. PMID: 37804063
Bedside Diagnosis for Disseminated Deep Dermatophytosis: a Case Series Study.
Xia XJ, Shen H, Zhi HL, Zhong Y, Sang B, Lv WW, Li QP, Liu ZH
Mycopathologia 2022 Jun;187(2-3):189-197. Epub 2022 Apr 20 doi: 10.1007/s11046-022-00633-w. PMID: 35445313
Trichophyton onychomycosis and deep dermatophytosis in a post-heart transplant patient.
Sriram N, Rutherford A, La Hoz R, Thomas C
Transpl Infect Dis 2022 Jun;24(3):e13830. Epub 2022 Apr 6 doi: 10.1111/tid.13830. PMID: 35325503
Deep dermatophytosis caused by Trichophyton rubrum.
Huang C, Peng Y, Zhang Y, Li R, Wan Z, Wang X
Lancet Infect Dis 2019 Dec;19(12):1380. doi: 10.1016/S1473-3099(19)30551-1. PMID: 31782403
New clinical phenotypes of fungal infections in special hosts.
Pilmis B, Puel A, Lortholary O, Lanternier F
Clin Microbiol Infect 2016 Aug;22(8):681-7. Epub 2016 May 26 doi: 10.1016/j.cmi.2016.05.016. PMID: 27237547

Therapy

Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation.
Tan J, Yu Q, Gao Z, Yang H, Chen Q, Yang L
Front Immunol 2022;13:1015000. Epub 2022 Sep 28 doi: 10.3389/fimmu.2022.1015000. PMID: 36248888Free PMC Article
Trichophyton onychomycosis and deep dermatophytosis in a post-heart transplant patient.
Sriram N, Rutherford A, La Hoz R, Thomas C
Transpl Infect Dis 2022 Jun;24(3):e13830. Epub 2022 Apr 6 doi: 10.1111/tid.13830. PMID: 35325503
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients.
Silva L, Sousa J, Toscano C, Viana I
An Bras Dermatol 2022 Mar-Apr;97(2):223-227. Epub 2022 Jan 20 doi: 10.1016/j.abd.2021.05.014. PMID: 35065846Free PMC Article
Severe dermatophytosis in solid organ transplant recipients: A French retrospective series and literature review.
Rouzaud C, Chosidow O, Brocard A, Fraitag S, Scemla A, Anglicheau D, Bouaziz JD, Dupin N, Bougnoux ME, Hay R, Lortholary O, Lanternier F; French Mycoses Study Group
Transpl Infect Dis 2018 Feb;20(1) Epub 2018 Jan 25 doi: 10.1111/tid.12799. PMID: 29094463
Deep dermatophytosis caused by Trichophyton rubrum.
Warycha MA, Leger M, Tzu J, Kamino H, Stein J
Dermatol Online J 2011 Oct 15;17(10):21. PMID: 22031647

Prognosis

Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia.
Song Y, Wang X, Li Q, Zhang R, de Hoog S, Li R
Emerg Microbes Infect 2023 Dec;12(1):2208685. doi: 10.1080/22221751.2023.2208685. PMID: 37128909Free PMC Article
Successful Allogenic Stem Cell Transplantation in Patients with Inherited CARD9 Deficiency.
Queiroz-Telles F, Mercier T, Maertens J, Sola CBS, Bonfim C, Lortholary O, Constantino-Silva RMN, Schrijvers R, Hagen F, Meis JF, Herkert PF, Breda GL, França JB, Filho NAR, Lanternier F, Casanova JL, Puel A, Grumach AS
J Clin Immunol 2019 Jul;39(5):462-469. Epub 2019 Jun 20 doi: 10.1007/s10875-019-00662-z. PMID: 31222666
A Unique Clinicopathological Manifestation of Fungal Infection: A Case Series of Deep Dermatophytosis in Immunosuppressed Patients.
Kershenovich R, Sherman S, Reiter O, Huss SR, Didkovsky E, Mimouni D, Hodak E, Segal R
Am J Clin Dermatol 2017 Oct;18(5):697-704. doi: 10.1007/s40257-017-0276-y. PMID: 28389891
Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9.
Jachiet M, Lanternier F, Rybojad M, Bagot M, Ibrahim L, Casanova JL, Puel A, Bouaziz JD
JAMA Dermatol 2015 Feb;151(2):192-4. doi: 10.1001/jamadermatol.2014.2154. PMID: 25372963
Extensive deep dermatophytosis cause by Trichophyton rubrum in a patient with liver cirrhosis and chronic renal failure.
Wu LC, Sun PL, Chang YT
Mycopathologia 2013 Dec;176(5-6):457-62. Epub 2013 Aug 28 doi: 10.1007/s11046-013-9696-2. PMID: 23982285

Clinical prediction guides

Successful Allogenic Stem Cell Transplantation in Patients with Inherited CARD9 Deficiency.
Queiroz-Telles F, Mercier T, Maertens J, Sola CBS, Bonfim C, Lortholary O, Constantino-Silva RMN, Schrijvers R, Hagen F, Meis JF, Herkert PF, Breda GL, França JB, Filho NAR, Lanternier F, Casanova JL, Puel A, Grumach AS
J Clin Immunol 2019 Jul;39(5):462-469. Epub 2019 Jun 20 doi: 10.1007/s10875-019-00662-z. PMID: 31222666
Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis.
Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S
Innate Immun 2016 Jul;22(5):316-24. Epub 2016 Apr 26 doi: 10.1177/1753425916645392. PMID: 27189427
Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9.
Jachiet M, Lanternier F, Rybojad M, Bagot M, Ibrahim L, Casanova JL, Puel A, Bouaziz JD
JAMA Dermatol 2015 Feb;151(2):192-4. doi: 10.1001/jamadermatol.2014.2154. PMID: 25372963
Markers for host-induced gene expression in Trichophyton dermatophytosis.
Kaufman G, Berdicevsky I, Woodfolk JA, Horwitz BA
Infect Immun 2005 Oct;73(10):6584-90. doi: 10.1128/IAI.73.10.6584-6590.2005. PMID: 16177334Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...