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Lung Carcinoma Metastatic in the Brain

MedGen UID:
235265
•Concept ID:
C1334441
•
Neoplastic Process
Synonym: Lung Carcinoma Metastatic to the Brain

Definition

A carcinoma that has spread to the brain from its original site in the lung, through the hematogenous route. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Carcinoma Metastatic in the Brain

Professional guidelines

PubMed

Oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Hendriks LE, Kerr KM, Menis J, Mok TS, Nestle U, Passaro A, Peters S, Planchard D, Smit EF, Solomon BJ, Veronesi G, Reck M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Apr;34(4):339-357. Epub 2023 Jan 23 doi: 10.1016/j.annonc.2022.12.009. PMID: 36872130
Small-cell lung cancer brain metastasis: From molecular mechanisms to diagnosis and treatment.
Zhu Y, Cui Y, Zheng X, Zhao Y, Sun G
Biochim Biophys Acta Mol Basis Dis 2022 Dec 1;1868(12):166557. Epub 2022 Sep 24 doi: 10.1016/j.bbadis.2022.166557. PMID: 36162624
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393

Recent clinical studies

Etiology

Stereotactic radiosurgery for the treatment of esophageal carcinoma brain metastases.
Zheng C, Weng Y, Xu Q
J BUON 2021 Sep-Oct;26(5):2126-2130. PMID: 34761626
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial.
Planchard D, Besse B, Groen HJM, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2016 Jul;17(7):984-993. Epub 2016 Jun 6 doi: 10.1016/S1470-2045(16)30146-2. PMID: 27283860Free PMC Article
Incidence and treatment of brain metastasis in patients with esophageal carcinoma.
Feng W, Zhang P, Zheng X, Chen M, Mao WM
World J Gastroenterol 2015 May 21;21(19):5805-12. doi: 10.3748/wjg.v21.i19.5805. PMID: 26019444Free PMC Article
Metastatic renal cell carcinoma.
Flanigan RC, Campbell SC, Clark JI, Picken MM
Curr Treat Options Oncol 2003 Oct;4(5):385-90. doi: 10.1007/s11864-003-0039-2. PMID: 12941198
Brain metastases.
Ewend MG, Carey LA, Morris DE, Harvey RD, Hensing TA
Curr Treat Options Oncol 2001 Dec;2(6):537-47. doi: 10.1007/s11864-001-0075-8. PMID: 12057099

Diagnosis

Systematic identification of a synthetic lethal interaction in brain-metastatic lung adenocarcinoma.
Moon JW, Hong BJ, Kim SK, Park MS, Lee H, Lee J, Kim MY
Cancer Lett 2024 Apr 28;588:216781. Epub 2024 Mar 15 doi: 10.1016/j.canlet.2024.216781. PMID: 38494150
Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Planchard D, Popat S, Kerr K, Novello S, Smit EF, Faivre-Finn C, Mok TS, Reck M, Van Schil PE, Hellmann MD, Peters S; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv192-iv237. doi: 10.1093/annonc/mdy275. PMID: 30285222
The role of the organ microenvironment in brain metastasis.
Fidler IJ
Semin Cancer Biol 2011 Apr;21(2):107-12. Epub 2010 Dec 16 doi: 10.1016/j.semcancer.2010.12.009. PMID: 21167939
Brain metastases.
Ewend MG, Carey LA, Morris DE, Harvey RD, Hensing TA
Curr Treat Options Oncol 2001 Dec;2(6):537-47. doi: 10.1007/s11864-001-0075-8. PMID: 12057099
Leptomeningeal carcinomatosis.
Grossman SA, Krabak MJ
Cancer Treat Rev 1999 Apr;25(2):103-19. doi: 10.1053/ctrv.1999.0119. PMID: 10395835

Therapy

Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs.
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Planchard D, Popat S, Kerr K, Novello S, Smit EF, Faivre-Finn C, Mok TS, Reck M, Van Schil PE, Hellmann MD, Peters S; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv192-iv237. doi: 10.1093/annonc/mdy275. PMID: 30285222
Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study.
Gadgeel S, Peters S, Mok T, Shaw AT, Kim DW, Ou SI, Pérol M, Wrona A, Novello S, Rosell R, Zeaiter A, Liu T, Nüesch E, Balas B, Camidge DR
Ann Oncol 2018 Nov 1;29(11):2214-2222. doi: 10.1093/annonc/mdy405. PMID: 30215676Free PMC Article
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial.
Planchard D, Besse B, Groen HJM, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2016 Jul;17(7):984-993. Epub 2016 Jun 6 doi: 10.1016/S1470-2045(16)30146-2. PMID: 27283860Free PMC Article
Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.
Aupérin A, Arriagada R, Pignon JP, Le Péchoux C, Gregor A, Stephens RJ, Kristjansen PE, Johnson BE, Ueoka H, Wagner H, Aisner J
N Engl J Med 1999 Aug 12;341(7):476-84. doi: 10.1056/NEJM199908123410703. PMID: 10441603

Prognosis

Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study.
Liu Y, Sun M, Xiong Y, Gu X, Zhang K, Liu L
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221132035. doi: 10.1177/15330338221132035. PMID: 36217877Free PMC Article
Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Planchard D, Popat S, Kerr K, Novello S, Smit EF, Faivre-Finn C, Mok TS, Reck M, Van Schil PE, Hellmann MD, Peters S; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv192-iv237. doi: 10.1093/annonc/mdy275. PMID: 30285222
Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial.
Planchard D, Besse B, Groen HJM, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2016 Jul;17(7):984-993. Epub 2016 Jun 6 doi: 10.1016/S1470-2045(16)30146-2. PMID: 27283860Free PMC Article
Incidence and treatment of brain metastasis in patients with esophageal carcinoma.
Feng W, Zhang P, Zheng X, Chen M, Mao WM
World J Gastroenterol 2015 May 21;21(19):5805-12. doi: 10.3748/wjg.v21.i19.5805. PMID: 26019444Free PMC Article

Clinical prediction guides

Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma.
Chaudhary S, Siddiqui JA, Appadurai MI, Maurya SK, Murakonda SP, Blowers E, Swanson BJ, Nasser MW, Batra SK, Lakshmanan I, Ganti AK
Exp Mol Med 2024 Jun;56(6):1450-1460. Epub 2024 Jun 3 doi: 10.1038/s12276-024-01255-6. PMID: 38825648Free PMC Article
Metastasis and recurrence patterns in the molecular subtypes of urothelial bladder cancer.
Sjödahl G, Eriksson P, Holmsten K, Abrahamsson J, Höglund M, Bernardo C, Ullén A, Liedberg F
Int J Cancer 2024 Jan 1;154(1):180-190. Epub 2023 Sep 6 doi: 10.1002/ijc.34715. PMID: 37671617
Specific organ metastases and prognosis in lung adenocarcinoma.
Zhao Z, Gao Y, Tan F, Xue Q, Gao S, He J
Thorac Cancer 2023 Mar;14(8):736-745. Epub 2023 Jan 24 doi: 10.1111/1759-7714.14801. PMID: 36694094Free PMC Article
Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA).
Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP
JAMA Oncol 2017 Jun 1;3(6):827-831. doi: 10.1001/jamaoncol.2016.3834. PMID: 27892978Free PMC Article
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial.
Planchard D, Besse B, Groen HJM, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2016 Jul;17(7):984-993. Epub 2016 Jun 6 doi: 10.1016/S1470-2045(16)30146-2. PMID: 27283860Free PMC Article

Recent systematic reviews

Genomic Alterations and the Incidence of Brain Metastases in Advanced and Metastatic NSCLC: A Systematic Review and Meta-Analysis.
Gillespie CS, Mustafa MA, Richardson GE, Alam AM, Lee KS, Hughes DM, Escriu C, Zakaria R
J Thorac Oncol 2023 Dec;18(12):1703-1713. Epub 2023 Jun 29 doi: 10.1016/j.jtho.2023.06.017. PMID: 37392903
Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
State of the Art in Combination Immuno/Radiotherapy for Brain Metastases: Systematic Review and Meta-Analysis.
Najafi M, Jahanbakhshi A, Gomar M, Iotti C, Giaccherini L, Rezaie O, Cavallieri F, Deantonio L, Bardoscia L, Botti A, Sardaro A, Cozzi S, Ciammella P
Curr Oncol 2022 Apr 22;29(5):2995-3012. doi: 10.3390/curroncol29050244. PMID: 35621634Free PMC Article
Targeted therapy for advanced anaplastic lymphoma kinase (<I>ALK</I>)-rearranged non-small cell lung cancer.
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393

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