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Ovarian Sclerosing Stromal Tumor

MedGen UID:
235083
•Concept ID:
C1368821
•
Neoplastic Process
Synonyms: Ovarian Sclerosing Stromal Neoplasm; Sclerosing Stromal Neoplasm of Ovary; Sclerosing Stromal Neoplasm of the Ovary; Sclerosing Stromal Tumor; Sclerosing Stromal Tumor of Ovary; Sclerosing Stromal Tumor of the Ovary

Definition

A benign ovarian stromal tumor characterized by the presence of cellular areas which contain fibroblasts and round cells. The cellular areas are separated by sclerotic or edematous hypocellular tissue. Symptoms include abdominal discomfort and menstrual abnormalities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Sclerosing Stromal Tumor

Professional guidelines

PubMed

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
CT and MR imaging of ovarian tumors with emphasis on differential diagnosis.
Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST
Radiographics 2002 Nov-Dec;22(6):1305-25. doi: 10.1148/rg.226025033. PMID: 12432104
Value of A103 (melan-A) immunostaining in the differential diagnosis of ovarian sex cord stromal tumours.
Stewart CJ, Nandini CL, Richmond JA
J Clin Pathol 2000 Mar;53(3):206-11. doi: 10.1136/jcp.53.3.206. PMID: 10823140Free PMC Article

Recent clinical studies

Etiology

Imaging characteristics of ovarian sclerosing stromal tumor.
Zhou Z, Chen X, Zeng Z, Zhang F, Yan J, Hou G
BMC Womens Health 2022 Sep 1;22(1):362. doi: 10.1186/s12905-022-01949-x. PMID: 36050720Free PMC Article
Sclerosing stromal tumor of the ovary associated with Meigs' syndrome: a case report.
Bildirici K, Yalçin OT, Ozalp SS, Peker B, Ozden H
Eur J Gynaecol Oncol 2004;25(4):528-9. PMID: 15285324

Diagnosis

Imaging characteristics of ovarian sclerosing stromal tumor.
Zhou Z, Chen X, Zeng Z, Zhang F, Yan J, Hou G
BMC Womens Health 2022 Sep 1;22(1):362. doi: 10.1186/s12905-022-01949-x. PMID: 36050720Free PMC Article
Ovarian Sclerosing Stromal Tumor and Müllerian Cyst in an 11-yr-old Girl: A Case Report and Review of the Literature.
Zhang X, Guo J, Yang L, Zhao Y, Zhang Y, Wang P
Int J Gynecol Pathol 2020 Mar;39(2):e5-e10. doi: 10.1097/PGP.0000000000000629. PMID: 31433378
Clinicopathological Characteristics of Ovarian Sclerosing Stromal Tumor with an Emphasis on TFE3 Overexpression.
Park CK, Kim HS
Anticancer Res 2017 Oct;37(10):5441-5447. doi: 10.21873/anticanres.11972. PMID: 28982854
Study of an ovarian sclerosing stromal tumor presenting as vaginal bleeding in a 7-month-old.
Hall OR, Pascasio JM, Morrissette JJ, Newton C, Schwartz MZ, de Chadarévian JP
Pediatr Dev Pathol 2008 Jul-Aug;11(4):300-4. Epub 2007 Aug 22 doi: 10.2350/07-05-0281.1. PMID: 17990931
Ovarian sclerosing stromal tumor presenting as Meigs' syndrome with elevated CA-125.
Jung NH, Kim T, Kim HJ, Lee KW, Lee NW, Lee ES
J Obstet Gynaecol Res 2006 Dec;32(6):619-22. doi: 10.1111/j.1447-0756.2006.00466.x. PMID: 17100828

Therapy

Clinicopathological Characteristics of Ovarian Sclerosing Stromal Tumor with an Emphasis on TFE3 Overexpression.
Park CK, Kim HS
Anticancer Res 2017 Oct;37(10):5441-5447. doi: 10.21873/anticanres.11972. PMID: 28982854

Prognosis

Imaging characteristics of ovarian sclerosing stromal tumor.
Zhou Z, Chen X, Zeng Z, Zhang F, Yan J, Hou G
BMC Womens Health 2022 Sep 1;22(1):362. doi: 10.1186/s12905-022-01949-x. PMID: 36050720Free PMC Article
Sclerosing stromal tumor of the ovary associated with Meigs' syndrome: a case report.
Bildirici K, Yalçin OT, Ozalp SS, Peker B, Ozden H
Eur J Gynaecol Oncol 2004;25(4):528-9. PMID: 15285324

Clinical prediction guides

Imaging characteristics of ovarian sclerosing stromal tumor.
Zhou Z, Chen X, Zeng Z, Zhang F, Yan J, Hou G
BMC Womens Health 2022 Sep 1;22(1):362. doi: 10.1186/s12905-022-01949-x. PMID: 36050720Free PMC Article
Sclerosing stromal tumor of the ovary associated with endometrial adenocarcinoma: a case report.
Katsube Y, Iwaoki Y, Silverberg SG, Fujiwara A
Gynecol Oncol 1988 Mar;29(3):392-8. doi: 10.1016/0090-8258(88)90242-9. PMID: 2964389

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