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Laryngeal Precancerous Condition

MedGen UID:
233609
•Concept ID:
C1334376
•
Disease or Syndrome
Synonym: Laryngeal Premalignant Condition

Definition

A premalignant pathologic process that affects the epithelial cells of the laryngeal mucosa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Precancerous Condition

Professional guidelines

PubMed

Surgical Management of Oral Cancer.
Shanti RM, O'Malley BW Jr
Dent Clin North Am 2018 Jan;62(1):77-86. Epub 2017 Oct 16 doi: 10.1016/j.cden.2017.08.005. PMID: 29126495
Vocal fold leukoplakia: incidence, management, and prevention.
Parker NP
Curr Opin Otolaryngol Head Neck Surg 2017 Dec;25(6):464-468. doi: 10.1097/MOO.0000000000000406. PMID: 28857841
Diagnosis and initial management of gastroesophageal complications.
Kamal A, Vaezi MF
Best Pract Res Clin Gastroenterol 2010 Dec;24(6):799-820. doi: 10.1016/j.bpg.2010.09.008. PMID: 21126695

Recent clinical studies

Etiology

Dysplastic Lesions of the Larynx.
Olson C, Alexander R, Stinnett S
Otolaryngol Clin North Am 2023 Apr;56(2):233-246. doi: 10.1016/j.otc.2023.01.001. PMID: 37030937
Surgical Management of Oral Cancer.
Shanti RM, O'Malley BW Jr
Dent Clin North Am 2018 Jan;62(1):77-86. Epub 2017 Oct 16 doi: 10.1016/j.cden.2017.08.005. PMID: 29126495
Human papillomavirus-associated diseases.
Grce M, Mravak-Stipetić M
Clin Dermatol 2014 Mar-Apr;32(2):253-8. Epub 2013 Oct 30 doi: 10.1016/j.clindermatol.2013.10.006. PMID: 24559561
Laryngeal papilloma--precancerous condition?
Klozar J, Taudy M, Betka J, Kana R
Acta Otolaryngol Suppl 1997;527:100-2. PMID: 9197493
Pachyonychia congenita.
Feinstein A, Friedman J, Schewach-Millet M
J Am Acad Dermatol 1988 Oct;19(4):705-11. doi: 10.1016/s0190-9622(88)70226-1. PMID: 3053803

Diagnosis

Dysplastic Lesions of the Larynx.
Olson C, Alexander R, Stinnett S
Otolaryngol Clin North Am 2023 Apr;56(2):233-246. doi: 10.1016/j.otc.2023.01.001. PMID: 37030937
The White Lesion, Hyperkeratosis, and Dysplasia.
Ali SA, Smith JD, Hogikyan ND
Otolaryngol Clin North Am 2019 Aug;52(4):703-712. Epub 2019 May 8 doi: 10.1016/j.otc.2019.03.014. PMID: 31078307
Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric Cancer.
Zhang P, Yang M, Zhang Y, Xiao S, Lai X, Tan A, Du S, Li S
Cell Rep 2019 May 7;27(6):1934-1947.e5. doi: 10.1016/j.celrep.2019.04.052. PMID: 31067475
Gastroesophageal reflux disease.
Kahrilas PJ
JAMA 1996 Sep 25;276(12):983-8. PMID: 8805734
The human papillomaviruses.
Orth G, Jablonska S, Breitburd F, Favre M, Croissant O
Bull Cancer 1978;65(2):151-64. PMID: 212142

Therapy

Gastroesophageal reflux and carcinoma of larynx or pharynx: a meta-analysis.
Zhang D, Zhou J, Chen B, Zhou L, Tao L
Acta Otolaryngol 2014 Oct;134(10):982-9. Epub 2014 Aug 18 doi: 10.3109/00016489.2014.927592. PMID: 25131391
Laryngeal dysplasia: aetiology and molecular biology.
Sadri M, McMahon J, Parker A
J Laryngol Otol 2006 Mar;120(3):170-7. Epub 2005 Dec 14 doi: 10.1017/S0022215105005360. PMID: 16372991
Gastroesophageal reflux disease.
Kahrilas PJ
JAMA 1996 Sep 25;276(12):983-8. PMID: 8805734
Retinoids in cancer prevention and therapy.
Bollag W, Holdener EE
Ann Oncol 1992 Jul;3(7):513-26. doi: 10.1093/oxfordjournals.annonc.a058252. PMID: 1498071
Papillomaviruses and interferon.
Androphy EJ
Ciba Found Symp 1986;120:221-34. doi: 10.1002/9780470513309.ch15. PMID: 2424679

Prognosis

Recent insights into the biology of Barrett's esophagus.
Badgery H, Chong L, Iich E, Huang Q, Georgy SR, Wang DH, Read M
Ann N Y Acad Sci 2020 Dec;1481(1):198-209. Epub 2020 Jul 17 doi: 10.1111/nyas.14432. PMID: 32681541
Histology of Barrett's Metaplasia: Do Goblet Cells Matter?
Odze R
Dig Dis Sci 2018 Aug;63(8):2042-2051. doi: 10.1007/s10620-018-5151-z. PMID: 29998421
Vocal fold leukoplakia: incidence, management, and prevention.
Parker NP
Curr Opin Otolaryngol Head Neck Surg 2017 Dec;25(6):464-468. doi: 10.1097/MOO.0000000000000406. PMID: 28857841
Laryngeal papilloma--precancerous condition?
Klozar J, Taudy M, Betka J, Kana R
Acta Otolaryngol Suppl 1997;527:100-2. PMID: 9197493
Gastroesophageal reflux disease.
Kahrilas PJ
JAMA 1996 Sep 25;276(12):983-8. PMID: 8805734

Clinical prediction guides

Laryngopharyngeal Reflux in Hypertrophic Laryngeal Diseases.
Han H, Lyu Q, Zhao J
Ear Nose Throat J 2022 May;101(4):NP158-NP163. Epub 2020 Aug 31 doi: 10.1177/0145561320953232. PMID: 32865459
Recent insights into the biology of Barrett's esophagus.
Badgery H, Chong L, Iich E, Huang Q, Georgy SR, Wang DH, Read M
Ann N Y Acad Sci 2020 Dec;1481(1):198-209. Epub 2020 Jul 17 doi: 10.1111/nyas.14432. PMID: 32681541
Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.
Mannelli G, Cecconi L, Gallo O
Crit Rev Oncol Hematol 2016 Oct;106:64-90. Epub 2016 Aug 3 doi: 10.1016/j.critrevonc.2016.07.004. PMID: 27637353
Gastroesophageal reflux disease.
Kahrilas PJ
JAMA 1996 Sep 25;276(12):983-8. PMID: 8805734
The human papillomaviruses.
Orth G, Jablonska S, Breitburd F, Favre M, Croissant O
Bull Cancer 1978;65(2):151-64. PMID: 212142

Recent systematic reviews

Diagnostic value of autofluorescence laryngoscope in early laryngeal carcinoma and precancerous lesions: A systematic review and meta-analysis.
Ge MW, Ni HT, Huang JW, Fan ZH, Shen WQ, Chen HL
Photodiagnosis Photodyn Ther 2021 Sep;35:102460. Epub 2021 Jul 27 doi: 10.1016/j.pdpdt.2021.102460. PMID: 34329763
Utility of narrowband imaging in the diagnosis of laryngeal leukoplakia: Systematic review and meta-analysis.
Ahmadzada S, Vasan K, Sritharan N, Singh N, Smith M, Hull I, Riffat F
Head Neck 2020 Nov;42(11):3427-3437. Epub 2020 Sep 23 doi: 10.1002/hed.26428. PMID: 32965766
Can the Ni classification of vessels predict neoplasia? A systematic review and meta-analysis.
Mehlum CS, Rosenberg T, Dyrvig AK, Groentved AM, Kjaergaard T, Godballe C
Laryngoscope 2018 Jan;128(1):168-176. Epub 2017 Jun 10 doi: 10.1002/lary.26721. PMID: 28600823
Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.
Mannelli G, Cecconi L, Gallo O
Crit Rev Oncol Hematol 2016 Oct;106:64-90. Epub 2016 Aug 3 doi: 10.1016/j.critrevonc.2016.07.004. PMID: 27637353
Gastroesophageal reflux and carcinoma of larynx or pharynx: a meta-analysis.
Zhang D, Zhou J, Chen B, Zhou L, Tao L
Acta Otolaryngol 2014 Oct;134(10):982-9. Epub 2014 Aug 18 doi: 10.3109/00016489.2014.927592. PMID: 25131391

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