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Immature Granulocytic Sarcoma

MedGen UID:
232635
•Concept ID:
C1334153
•
Neoplastic Process

Definition

A granulocytic sarcoma composed of myeloblasts and promyelocytes (WHO 2001). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmature Granulocytic Sarcoma

Professional guidelines

PubMed

Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal.
Valent P, Sotlar K, Sperr WR, Escribano L, Yavuz S, Reiter A, George TI, Kluin-Nelemans HC, Hermine O, Butterfield JH, Hägglund H, Ustun C, Hornick JL, Triggiani M, Radia D, Akin C, Hartmann K, Gotlib J, Schwartz LB, Verstovsek S, Orfao A, Metcalfe DD, Arock M, Horny HP
Ann Oncol 2014 Sep;25(9):1691-1700. Epub 2014 Mar 27 doi: 10.1093/annonc/mdu047. PMID: 24675021Free PMC Article
Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis.
Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T, Diebold J
Int J Surg Pathol 2003 Oct;11(4):271-82. doi: 10.1177/106689690301100404. PMID: 14615822

Recent clinical studies

Etiology

Malignant testicular tumors in children: A single institution's 12-year experience.
Chiu CC, Jaing TH, Lai JY, Chen SH, Chang TY, Hsueh C, Wen YC, Tsay PK
Medicine (Baltimore) 2022 Jul 22;101(29):e29735. doi: 10.1097/MD.0000000000029735. PMID: 35866814Free PMC Article
Clinicopathological and molecular characteristics of extramedullary acute myeloid leukaemia.
Ullman DI, Dorn D, Jones JA, Fasciano D, Ping Z, Kanakis C, Koenig RG, Salzman D, Peker D
Histopathology 2019 Aug;75(2):185-192. Epub 2019 Jun 20 doi: 10.1111/his.13864. PMID: 30916362
Unravelling chloroma: review of imaging findings.
Singh A, Kumar P, Chandrashekhara SH, Kumar A
Br J Radiol 2017 Jul;90(1075):20160710. Epub 2017 May 23 doi: 10.1259/bjr.20160710. PMID: 28445074Free PMC Article
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal.
Valent P, Sotlar K, Sperr WR, Escribano L, Yavuz S, Reiter A, George TI, Kluin-Nelemans HC, Hermine O, Butterfield JH, Hägglund H, Ustun C, Hornick JL, Triggiani M, Radia D, Akin C, Hartmann K, Gotlib J, Schwartz LB, Verstovsek S, Orfao A, Metcalfe DD, Arock M, Horny HP
Ann Oncol 2014 Sep;25(9):1691-1700. Epub 2014 Mar 27 doi: 10.1093/annonc/mdu047. PMID: 24675021Free PMC Article

Diagnosis

Gene Mutations and Targeted Therapies of Myeloid Sarcoma.
Fu L, Zhang Z, Chen Z, Fu J, Hong P, Feng W
Curr Treat Options Oncol 2023 Apr;24(4):338-352. Epub 2023 Mar 6 doi: 10.1007/s11864-023-01063-6. PMID: 36877373
Bladder granulocytic sarcoma in a child: case report and literature review.
Tuna R, Karaman S, Oktar T, Anak S, Doğan Ö, Ünüvar A, Tuğcu D, Bayramoğlu Z, Kılıç SÇ, Çelik Aİ, Karakaş Z
Turk J Pediatr 2022;64(1):152-159. doi: 10.24953/turkjped.2020.275. PMID: 35286044
A clinical report of intracranial granulocytic sarcoma and a literature review.
Cheng H, Di G, Gao W, Chenhui Z, Jiang X
Int J Neurosci 2022 Sep;132(9):945-949. Epub 2021 Mar 8 doi: 10.1080/00207454.2020.1858824. PMID: 33272089
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Post-bone-marrow-transplant leukemia cutis.
Pulgar F, Vélez D, Valdeolivas N, García J, Cabrera A, Pericet L, Trasobares L, Medina S, García M
Dermatol Online J 2013 Feb 15;19(2):6. PMID: 23473276

Therapy

Gene Mutations and Targeted Therapies of Myeloid Sarcoma.
Fu L, Zhang Z, Chen Z, Fu J, Hong P, Feng W
Curr Treat Options Oncol 2023 Apr;24(4):338-352. Epub 2023 Mar 6 doi: 10.1007/s11864-023-01063-6. PMID: 36877373
Clinical characteristics and management of primary granulocytic sarcoma of the oral cavity: A case report and literature review.
Hu YG, Deng XH, Lei W, Li XL
Medicine (Baltimore) 2020 Oct 23;99(43):e22820. doi: 10.1097/MD.0000000000022820. PMID: 33120806Free PMC Article
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Chemotherapy Options for Poor Responders to Neoadjuvant Chemotherapy for Orbital Granulocytic Sarcoma.
Gossai N, Cafferty R, Weigel B
Curr Treat Options Oncol 2016 Jul;17(7):38. doi: 10.1007/s11864-016-0411-7. PMID: 27300546
Granulocytic sarcoma mimicking HSV encephalitis.
Shah RS, Shin RK, Castellani RJ
Neurologist 2010 Sep;16(5):319-21. doi: 10.1097/NRL.0b013e3181b0be8d. PMID: 20827123

Prognosis

Knowing the myeloid-derived suppressor cells: Another enemy of sarcomas patients.
García-Domínguez DJ, Sánchez-Margalet V, de la Cruz-Merino L, Hontecillas-Prieto L
Int Rev Cell Mol Biol 2023;375:93-116. Epub 2023 Jan 11 doi: 10.1016/bs.ircmb.2022.11.003. PMID: 36967155
Central nervous system granulocytic sarcoma: Report of 2 cases and review of the literature.
Vilariño A, Carrasco Moro R, Sosa FP, Ley Urzaiz L, Vicente MLÁ
Neurocirugia (Astur : Engl Ed) 2020 Jan-Feb;31(1):47-51. Epub 2019 May 31 doi: 10.1016/j.neucir.2019.04.006. PMID: 31160224
Clinical characteristics and prognosis of nonleukemic myeloid sarcoma.
He J, Zhu L, Ye X, Li L, Zhu J, Zhang J, Xie W, Shi J, Zheng W, Wei G, Sun J, Cai Z, He H
Am J Med Sci 2014 Jun;347(6):434-8. doi: 10.1097/MAJ.0b013e31829ca859. PMID: 23928547
Post-bone-marrow-transplant leukemia cutis.
Pulgar F, Vélez D, Valdeolivas N, García J, Cabrera A, Pericet L, Trasobares L, Medina S, García M
Dermatol Online J 2013 Feb 15;19(2):6. PMID: 23473276
Granulocytic sarcoma of the small intestine.
Kohl SK, Aoun P
Arch Pathol Lab Med 2006 Oct;130(10):1570-4. doi: 10.5858/2006-130-1570-GSOTSI. PMID: 17090205

Clinical prediction guides

ERG Immunoreactivity in Blastic Hematolymphoid Neoplasms: Diagnostic Pitfall in the Workup of Undifferentiated Malignant Neoplasms.
Koo M, Natkunam Y
Appl Immunohistochem Mol Morphol 2022 Jan 1;30(1):42-48. doi: 10.1097/PAI.0000000000000958. PMID: 34261976
Diagnosis and surgical treatment of primary isolated aggressive lumbar myeloid sarcoma: a rare case report and review of the literatures.
Bai CR, Li X, Wang JS, Li JJ, Liu N, Fei Q, Li D, Yang Y
BMC Musculoskelet Disord 2021 Feb 24;22(1):220. doi: 10.1186/s12891-021-04066-2. PMID: 33627110Free PMC Article
Male with myelofibrosis and ulceronecrotic lesions.
Santos FDSD, Grupioni PV, Towersey L, Bernardes Filho F
Rev Assoc Med Bras (1992) 2018 Dec;64(12):1073-1074. doi: 10.1590/1806-9282.64.12.1073. PMID: 30569980
Oral myeloid sarcoma: two case reports.
Yap M, Hewson I, McLean C, Ciciulla J
Aust Dent J 2014 Dec;59(4):511-5. Epub 2014 Sep 16 doi: 10.1111/adj.12220. PMID: 25159834
Clinical characteristics and prognosis of nonleukemic myeloid sarcoma.
He J, Zhu L, Ye X, Li L, Zhu J, Zhang J, Xie W, Shi J, Zheng W, Wei G, Sun J, Cai Z, He H
Am J Med Sci 2014 Jun;347(6):434-8. doi: 10.1097/MAJ.0b013e31829ca859. PMID: 23928547

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