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Breast Neuroendocrine Tumor G1

MedGen UID:
232330
•Concept ID:
C1332839
•
Neoplastic Process

Definition

A well-differentiated, low grade neuroendocrine neoplasm arising from the breast. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Neuroendocrine Tumor G1

Professional guidelines

PubMed

The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Alterations in Ki67 Labeling Following Treatment of Poorly Differentiated Neuroendocrine Carcinomas: A Potential Diagnostic Pitfall.
Vyas M, Tang LH, Rekhtman N, Klimstra DS
Am J Surg Pathol 2021 Jan;45(1):25-34. doi: 10.1097/PAS.0000000000001602. PMID: 33177340Free PMC Article
Radio hyperthermia for re-treatment of superficial tumours.
Gabriele P, Ferrara T, Baiotto B, Garibaldi E, Marini PG, Penduzzu G, Giovannini V, Bardati F, Guiot C
Int J Hyperthermia 2009 May;25(3):189-98. doi: 10.1080/02656730802669593. PMID: 19212860

Recent clinical studies

Etiology

A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies.
Lin CC, Garralda E, Schöffski P, Hong DS, Siu LL, Martin M, Maur M, Hui R, Soo RA, Chiu J, Zhang T, Ma B, Kyi C, Tan DS, Cassier PA, Sarantopoulos J, Weickhardt A, Carvajal RD, Spratlin J, Esaki T, Rolland F, Akerley W, Deschler-Baier B, Rispoli L, Samant TS, Chowdhury NR, Gusenleitner D, Kwak EL, Askoxylakis V, De Braud F
Oncoimmunology 2024;13(1):2290787. Epub 2023 Dec 20 doi: 10.1080/2162402X.2023.2290787. PMID: 38170160Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article
Detection of NRG1 Gene Fusions in Solid Tumors.
Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV
Clin Cancer Res 2019 Aug 15;25(16):4966-4972. Epub 2019 Apr 15 doi: 10.1158/1078-0432.CCR-19-0160. PMID: 30988082Free PMC Article

Diagnosis

The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?-A Case Report and Review of the Literature.
Chiorean DM, Mitranovici MI, Mureșan MC, Buicu CF, Moraru R, Moraru L, Cotoi TC, Cotoi OS, Apostol A, Turdean SG, Mărginean C, Petre I, Oală IE, Simon-Szabo Z, Ivan V, Roșca AN, Toru HS
Medicina (Kaunas) 2023 Mar 28;59(4) doi: 10.3390/medicina59040672. PMID: 37109630Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors.
Thiis-Evensen E, Kjellman M, Knigge U, Gronbaek H, Schalin-Jäntti C, Welin S, Sorbye H, Del Pilar Schneider M, Belusa R; Nordic NET Biomarker Group
J Neuroendocrinol 2022 Jul;34(7):e13176. Epub 2022 Jul 13 doi: 10.1111/jne.13176. PMID: 35829662Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article

Therapy

A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies.
Lin CC, Garralda E, Schöffski P, Hong DS, Siu LL, Martin M, Maur M, Hui R, Soo RA, Chiu J, Zhang T, Ma B, Kyi C, Tan DS, Cassier PA, Sarantopoulos J, Weickhardt A, Carvajal RD, Spratlin J, Esaki T, Rolland F, Akerley W, Deschler-Baier B, Rispoli L, Samant TS, Chowdhury NR, Gusenleitner D, Kwak EL, Askoxylakis V, De Braud F
Oncoimmunology 2024;13(1):2290787. Epub 2023 Dec 20 doi: 10.1080/2162402X.2023.2290787. PMID: 38170160Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Mechanistic Target of Rapamycin (mTOR) Inhibitors.
Wang D, Eisen HJ
Handb Exp Pharmacol 2022;272:53-72. doi: 10.1007/164_2021_553. PMID: 35091825
Neuroendocrine breast cancer.
Graça S, Esteves J, Costa S, Vale S, Maciel J
BMJ Case Rep 2012 Aug 13;2012 doi: 10.1136/bcr.12.2011.5343. PMID: 22891013Free PMC Article

Prognosis

Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors.
Thiis-Evensen E, Kjellman M, Knigge U, Gronbaek H, Schalin-Jäntti C, Welin S, Sorbye H, Del Pilar Schneider M, Belusa R; Nordic NET Biomarker Group
J Neuroendocrinol 2022 Jul;34(7):e13176. Epub 2022 Jul 13 doi: 10.1111/jne.13176. PMID: 35829662Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article
Neuroendocrine breast cancer.
Graça S, Esteves J, Costa S, Vale S, Maciel J
BMJ Case Rep 2012 Aug 13;2012 doi: 10.1136/bcr.12.2011.5343. PMID: 22891013Free PMC Article
Vitamin D and systemic cancer: is this relevant to malignant melanoma?
Osborne JE, Hutchinson PE
Br J Dermatol 2002 Aug;147(2):197-213. doi: 10.1046/j.1365-2133.2002.04960.x. PMID: 12174089

Clinical prediction guides

Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Changes in survival in de novo metastatic cancer in an era of new medicines.
Luyendijk M, Visser O, Blommestein HM, de Hingh IHJT, Hoebers FJP, Jager A, Sonke GS, de Vries EGE, Uyl-de Groot CA, Siesling S
J Natl Cancer Inst 2023 Jun 8;115(6):628-635. doi: 10.1093/jnci/djad020. PMID: 36978244Free PMC Article
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors.
Thiis-Evensen E, Kjellman M, Knigge U, Gronbaek H, Schalin-Jäntti C, Welin S, Sorbye H, Del Pilar Schneider M, Belusa R; Nordic NET Biomarker Group
J Neuroendocrinol 2022 Jul;34(7):e13176. Epub 2022 Jul 13 doi: 10.1111/jne.13176. PMID: 35829662Free PMC Article
PTEN signaling pathways in melanoma.
Wu H, Goel V, Haluska FG
Oncogene 2003 May 19;22(20):3113-22. doi: 10.1038/sj.onc.1206451. PMID: 12789288

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