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Grade 3 Colorectal Adenocarcinoma

MedGen UID:
232251
Concept ID:
C1333856
Neoplastic Process
Synonyms: Grade III Colorectal Adenocarcinoma; High Grade Colorectal Adenocarcinoma; Poorly Differentiated Colorectal Adenocarcinoma

Definition

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Colorectal Adenocarcinoma

Professional guidelines

PubMed

Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Ott C, Gerken M, Hirsch D, Fest P, Fichtner-Feigl S, Munker S, Schnoy E, Stroszczynski C, Vogelhuber M, Herr W, Evert M, Reng M, Schlitt HJ, Klinkhammer-Schalke M, Teufel A
Digestion 2018;98(3):143-152. Epub 2018 Jun 5 doi: 10.1159/000487710. PMID: 29870979
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article

Recent clinical studies

Etiology

Wismayer R, Kiwanuka J, Wabinga H, Odida M
World J Surg Oncol 2023 Jul 22;21(1):215. doi: 10.1186/s12957-023-03094-7. PMID: 37480083Free PMC Article
Kim J, Tomita N, Suriawinata AA, Hassanpour S
Am J Pathol 2023 Mar;193(3):332-340. Epub 2022 Dec 21 doi: 10.1016/j.ajpath.2022.12.003. PMID: 36563748Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Cats A, Jansen EPM, van Grieken NCT, Sikorska K, Lind P, Nordsmark M, Meershoek-Klein Kranenbarg E, Boot H, Trip AK, Swellengrebel HAM, van Laarhoven HWM, Putter H, van Sandick JW, van Berge Henegouwen MI, Hartgrink HH, van Tinteren H, van de Velde CJH, Verheij M; CRITICS investigators
Lancet Oncol 2018 May;19(5):616-628. Epub 2018 Apr 9 doi: 10.1016/S1470-2045(18)30132-3. PMID: 29650363
de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A
J Clin Oncol 2000 Aug;18(16):2938-47. doi: 10.1200/JCO.2000.18.16.2938. PMID: 10944126

Diagnosis

Bech JM, Terkelsen T, Bartels AS, Coscia F, Doll S, Zhao S, Zhang Z, Brünner N, Lindebjerg J, Madsen GI, Fang X, Mann M, Afonso Moreira JM
Gastroenterology 2023 Jul;165(1):121-132.e5. Epub 2023 Mar 24 doi: 10.1053/j.gastro.2023.03.208. PMID: 36966943
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Cercek A, Boerner T, Tan BR, Chou JF, Gönen M, Boucher TM, Hauser HF, Do RKG, Lowery MA, Harding JJ, Varghese AM, Reidy-Lagunes D, Saltz L, Schultz N, Kingham TP, D'Angelica MI, DeMatteo RP, Drebin JA, Allen PJ, Balachandran VP, Lim KH, Sanchez-Vega F, Vachharajani N, Majella Doyle MB, Fields RC, Hawkins WG, Strasberg SM, Chapman WC, Diaz LA Jr, Kemeny NE, Jarnagin WR
JAMA Oncol 2020 Jan 1;6(1):60-67. doi: 10.1001/jamaoncol.2019.3718. PMID: 31670750Free PMC Article
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M
Metabolism 2019 Mar;92:121-135. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.001. PMID: 30445141

Therapy

Thompson HM, Omer DM, Lin S, Kim JK, Yuval JB, Verheij FS, Qin LX, Gollub MJ, Wu AJ, Lee M, Patil S, Hezel AF, Marcet JE, Cataldo PA, Polite BN, Herzig DO, Liska D, Oommen S, Friel CM, Ternent CA, Coveler AL, Hunt SR, Garcia-Aguilar J; OPRA Consortium
JAMA Netw Open 2024 Jan 2;7(1):e2350903. doi: 10.1001/jamanetworkopen.2023.50903. PMID: 38194231Free PMC Article
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A
Lancet Oncol 2019 Aug;20(8):1070-1082. Epub 2019 Jun 28 doi: 10.1016/S1470-2045(19)30272-4. PMID: 31262657Free PMC Article
Xu RH, Muro K, Morita S, Iwasa S, Han SW, Wang W, Kotaka M, Nakamura M, Ahn JB, Deng YH, Kato T, Cho SH, Ba Y, Matsuoka H, Lee KW, Zhang T, Yamada Y, Sakamoto J, Park YS, Kim TW
Lancet Oncol 2018 May;19(5):660-671. Epub 2018 Mar 16 doi: 10.1016/S1470-2045(18)30140-2. PMID: 29555258
de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A
J Clin Oncol 2000 Aug;18(16):2938-47. doi: 10.1200/JCO.2000.18.16.2938. PMID: 10944126

Prognosis

Wu P, Deng W, Yan L, Wang C, Lou Y, Wang C
Int J Colorectal Dis 2023 Feb 11;38(1):35. doi: 10.1007/s00384-023-04343-7. PMID: 36773067
Gutierrez C, Ogino S, Meyerhardt JA, Iorgulescu JB
JCO Precis Oncol 2023 Jan;7:e2200179. doi: 10.1200/PO.22.00179. PMID: 36716414Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Fuchs CS, Marshall J, Mitchell E, Wierzbicki R, Ganju V, Jeffery M, Schulz J, Richards D, Soufi-Mahjoubi R, Wang B, Barrueco J
J Clin Oncol 2007 Oct 20;25(30):4779-86. doi: 10.1200/JCO.2007.11.3357. PMID: 17947725

Clinical prediction guides

Wu P, Deng W, Yan L, Wang C, Lou Y, Wang C
Int J Colorectal Dis 2023 Feb 11;38(1):35. doi: 10.1007/s00384-023-04343-7. PMID: 36773067
Saeed A, Park R, Dai J, Al-Rajabi R, Kasi A, Baranda J, Williamson S, Saeed A, Ripp J, Collins Z, Mulvaney K, Shugrue M, Firth-Braun J, Godwin AK, Madan R, Phadnis M, Sun W
Cell Rep Med 2023 Feb 21;4(2):100916. Epub 2023 Jan 25 doi: 10.1016/j.xcrm.2023.100916. PMID: 36702123Free PMC Article
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Cats A, Jansen EPM, van Grieken NCT, Sikorska K, Lind P, Nordsmark M, Meershoek-Klein Kranenbarg E, Boot H, Trip AK, Swellengrebel HAM, van Laarhoven HWM, Putter H, van Sandick JW, van Berge Henegouwen MI, Hartgrink HH, van Tinteren H, van de Velde CJH, Verheij M; CRITICS investigators
Lancet Oncol 2018 May;19(5):616-628. Epub 2018 Apr 9 doi: 10.1016/S1470-2045(18)30132-3. PMID: 29650363
Xu RH, Muro K, Morita S, Iwasa S, Han SW, Wang W, Kotaka M, Nakamura M, Ahn JB, Deng YH, Kato T, Cho SH, Ba Y, Matsuoka H, Lee KW, Zhang T, Yamada Y, Sakamoto J, Park YS, Kim TW
Lancet Oncol 2018 May;19(5):660-671. Epub 2018 Mar 16 doi: 10.1016/S1470-2045(18)30140-2. PMID: 29555258

Recent systematic reviews

Gupta N, Verma N, Patel B
J Gastrointest Cancer 2024 Dec;55(4):1485-1497. Epub 2024 Aug 20 doi: 10.1007/s12029-024-01103-w. PMID: 39160369
Lauricella S, Fabris S, Sylla P
Surg Endosc 2023 Jan;37(1):48-61. Epub 2022 Aug 3 doi: 10.1007/s00464-022-09462-w. PMID: 35920906
van Dorp M, Bousema JE, Torensma B, Dickhoff C, van den Broek FJC, Schreurs WH, Gonzalez M, Kazemier G, Heineman DJ
Eur J Surg Oncol 2022 Jan;48(1):253-260. Epub 2021 Oct 11 doi: 10.1016/j.ejso.2021.09.020. PMID: 34656390
Aalami AH, Abdeahad H, Mesgari M, Sahebkar A
Eur J Clin Invest 2021 Feb;51(2):e13448. Epub 2020 Dec 5 doi: 10.1111/eci.13448. PMID: 33244751
Faggiano A, Malandrino P, Modica R, Agrimi D, Aversano M, Bassi V, Giordano EA, Guarnotta V, Logoluso FA, Messina E, Nicastro V, Nuzzo V, Sciaraffia M, Colao A
Oncologist 2016 Jul;21(7):875-86. Epub 2016 Apr 6 doi: 10.1634/theoncologist.2015-0420. PMID: 27053503Free PMC Article

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