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Calcifying fibrous tumor

MedGen UID:
232021
•Concept ID:
C1332833
•
Neoplastic Process
Synonyms: Calcifying Fibrous Pseudotumor; calcifying fibrous pseudotumor; Calcifying Fibrous Tumor; calcifying fibrous tumor; CFT
SNOMED CT: Calcifying fibrous tumor (703613000)
 
Monarch Initiative: MONDO:0006121

Definition

A benign well-circumscribed lesion arising from the soft tissues. It is characterized by the presence of fibroblasts, lymphoplasmacytic infiltrates, collagenous stroma formation, psammoma bodies, and dystrophic calcifications. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalcifying fibrous tumor

Professional guidelines

PubMed

Surgical approaches, anaesthetic management and outcome in pediatric superior mediastinal tumors.
Ahmed G, Hegazy MM, Raafat T, Hafez H, Fadel S, Elshafiey M
J Egypt Natl Canc Inst 2017 Sep;29(3):147-153. Epub 2017 Aug 31 doi: 10.1016/j.jnci.2017.08.001. PMID: 28844590
Endoscopic diagnosis and treatment of calcifying fibrous tumors.
Shi Q, Xu MD, Chen T, Zhong YS, Zhou PH, Wu HF, Yao LQ
Turk J Gastroenterol 2014 Dec;25 Suppl 1:153-6. doi: 10.5152/tjg.2014.4044. PMID: 25910296

Recent clinical studies

Etiology

Gastric calcifying fibrous tumors: Computed tomography findings and clinical manifestations.
Wang J, Ao W, Mao G, Jia Y, Xie Z, Gu C, Yang G
Medicine (Baltimore) 2021 Feb 5;100(5):e23334. doi: 10.1097/MD.0000000000023334. PMID: 33592822Free PMC Article
Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update.
Turbiville D, Zhang X
World J Gastroenterol 2020 Oct 7;26(37):5597-5605. doi: 10.3748/wjg.v26.i37.5597. PMID: 33071524Free PMC Article
Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor-A Systemic Review.
Tsai MK, Chen HY, Chuang ML, Chen CW, Jong GP
Medicina (Kaunas) 2020 Oct 14;56(10) doi: 10.3390/medicina56100541. PMID: 33066662Free PMC Article
Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract: a case series.
Pezhouh MK, Rezaei MK, Shabihkhani M, Ghosh A, Belchis D, Montgomery EA, Voltaggio L
Hum Pathol 2017 Apr;62:199-205. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.002. PMID: 28153506
Endoscopic diagnosis and treatment of calcifying fibrous tumors.
Shi Q, Xu MD, Chen T, Zhong YS, Zhou PH, Wu HF, Yao LQ
Turk J Gastroenterol 2014 Dec;25 Suppl 1:153-6. doi: 10.5152/tjg.2014.4044. PMID: 25910296

Diagnosis

Gastric calcifying fibrous tumors: Computed tomography findings and clinical manifestations.
Wang J, Ao W, Mao G, Jia Y, Xie Z, Gu C, Yang G
Medicine (Baltimore) 2021 Feb 5;100(5):e23334. doi: 10.1097/MD.0000000000023334. PMID: 33592822Free PMC Article
Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update.
Turbiville D, Zhang X
World J Gastroenterol 2020 Oct 7;26(37):5597-5605. doi: 10.3748/wjg.v26.i37.5597. PMID: 33071524Free PMC Article
Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor-A Systemic Review.
Tsai MK, Chen HY, Chuang ML, Chen CW, Jong GP
Medicina (Kaunas) 2020 Oct 14;56(10) doi: 10.3390/medicina56100541. PMID: 33066662Free PMC Article
Calcifying Fibrous Tumor of the Neck.
Baumann KB, Orestes MI, Heaton SM, Whiting RE, Wendzel NC, Foss RD
Head Neck Pathol 2020 Jun;14(2):507-511. Epub 2019 Nov 28 doi: 10.1007/s12105-019-01100-7. PMID: 31782118Free PMC Article
Calcifying Fibrous Tumor: Review of 157 Patients Reported in International Literature.
Chorti A, Papavramidis TS, Michalopoulos A
Medicine (Baltimore) 2016 May;95(20):e3690. doi: 10.1097/MD.0000000000003690. PMID: 27196478Free PMC Article

Therapy

Clinicopathologic Study of Calcifying Fibrous Tumor Emphasizing Different Anatomical Distribution and Favorable Prognosis.
Zhou J, Zhou L, Wu S, Li R, Yang X, Xu H, Zheng S, Wang A, Wang C
Biomed Res Int 2019;2019:5026860. Epub 2019 Jul 2 doi: 10.1155/2019/5026860. PMID: 31355265Free PMC Article
Surgical approaches, anaesthetic management and outcome in pediatric superior mediastinal tumors.
Ahmed G, Hegazy MM, Raafat T, Hafez H, Fadel S, Elshafiey M
J Egypt Natl Canc Inst 2017 Sep;29(3):147-153. Epub 2017 Aug 31 doi: 10.1016/j.jnci.2017.08.001. PMID: 28844590

Prognosis

Calcifying fibrous tumor: a rare case in the foot.
Bharadwaj UU, Akkaya Z, Horvai AE, Link TM, Gassert FG
Skeletal Radiol 2023 Aug;52(8):1619-1623. Epub 2023 Jan 25 doi: 10.1007/s00256-023-04282-y. PMID: 36695882
Clinicopathologic Study of Calcifying Fibrous Tumor Emphasizing Different Anatomical Distribution and Favorable Prognosis.
Zhou J, Zhou L, Wu S, Li R, Yang X, Xu H, Zheng S, Wang A, Wang C
Biomed Res Int 2019;2019:5026860. Epub 2019 Jul 2 doi: 10.1155/2019/5026860. PMID: 31355265Free PMC Article
Whole-exome sequencing identifies unique mutations and copy number losses in calcifying fibrous tumor of the pleura: report of 3 cases and review of the literature.
Mehrad M, LaFramboise WA, Lyons MA, Trejo Bittar HE, Yousem SA
Hum Pathol 2018 Aug;78:36-43. Epub 2018 Apr 22 doi: 10.1016/j.humpath.2018.04.005. PMID: 29689243
Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract: a case series.
Pezhouh MK, Rezaei MK, Shabihkhani M, Ghosh A, Belchis D, Montgomery EA, Voltaggio L
Hum Pathol 2017 Apr;62:199-205. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.002. PMID: 28153506
Familial peritoneal multifocal calcifying fibrous tumor.
Chen KT
Am J Clin Pathol 2003 Jun;119(6):811-5. doi: 10.1309/MXC6-TWEL-UUH4-20W0. PMID: 12817428

Clinical prediction guides

Gastric calcifying fibrous tumors: Computed tomography findings and clinical manifestations.
Wang J, Ao W, Mao G, Jia Y, Xie Z, Gu C, Yang G
Medicine (Baltimore) 2021 Feb 5;100(5):e23334. doi: 10.1097/MD.0000000000023334. PMID: 33592822Free PMC Article
A case of long-term unchanged calcifying fibrous tumor.
Miyamoto N, Yoshida M, Tsuboi M, Ootsuka K, Bando Y, Kakimoto T, Kawakita N, Takizawa H, Kondo K, Tangoku A
Gen Thorac Cardiovasc Surg 2020 Dec;68(12):1587-1590. Epub 2020 Jun 8 doi: 10.1007/s11748-020-01396-1. PMID: 32514881
Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract: a case series.
Pezhouh MK, Rezaei MK, Shabihkhani M, Ghosh A, Belchis D, Montgomery EA, Voltaggio L
Hum Pathol 2017 Apr;62:199-205. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.002. PMID: 28153506
Endoscopic diagnosis and treatment of calcifying fibrous tumors.
Shi Q, Xu MD, Chen T, Zhong YS, Zhou PH, Wu HF, Yao LQ
Turk J Gastroenterol 2014 Dec;25 Suppl 1:153-6. doi: 10.5152/tjg.2014.4044. PMID: 25910296
Unusual calcifying fibrous tumor in the fallopian tube: review and discussion of the differential diagnosis.
Xiao P, Peng JJ, Li Y, Tian XY, Li B, Li Z
Int J Gynecol Pathol 2014 Jan;33(1):40-4. doi: 10.1097/PGP.0b013e31827c637c. PMID: 24300534

Recent systematic reviews

Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor-A Systemic Review.
Tsai MK, Chen HY, Chuang ML, Chen CW, Jong GP
Medicina (Kaunas) 2020 Oct 14;56(10) doi: 10.3390/medicina56100541. PMID: 33066662Free PMC Article
Calcifying Fibrous Tumor: Review of 157 Patients Reported in International Literature.
Chorti A, Papavramidis TS, Michalopoulos A
Medicine (Baltimore) 2016 May;95(20):e3690. doi: 10.1097/MD.0000000000003690. PMID: 27196478Free PMC Article

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