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AIDS-Related Anal Carcinoma

MedGen UID:
231324
•Concept ID:
C1332038
•
Neoplastic Process
Synonym: AIDS-Related Anal Cancer

Definition

A carcinoma arising from the anus and occurring in HIV-positive patients. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Sexually transmitted human papillomavirus is detected in the majority of the cases. [from NCI]

Professional guidelines

PubMed

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399

Recent clinical studies

Etiology

Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping.
Dube Mandishora RS, Rounge TB, Fitzpatrick M, Christiansen IK, Ambur OH, Lagström S, Stray-Pedersen B, Tommasino M, Palefsky J, Chirenje ZM
PLoS One 2021;16(4):e0250426. Epub 2021 Apr 26 doi: 10.1371/journal.pone.0250426. PMID: 33901223Free PMC Article
The role of viral co-infection in HIV-associated non-AIDS-related cancers.
Riedel DJ, Tang LS, Rositch AF
Curr HIV/AIDS Rep 2015 Sep;12(3):362-72. doi: 10.1007/s11904-015-0276-6. PMID: 26152660Free PMC Article
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Opportunistic infections.
Vazquez E
Posit Aware 1996 Sep-Oct;7(5):12-3. PMID: 11363782
Epidemiology of AIDS-related malignancies.
Rabkin CS
Curr Opin Oncol 1994 Sep;6(5):492-6. doi: 10.1097/00001622-199409000-00008. PMID: 7827152

Diagnosis

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
Opportunistic infections.
Vazquez E
Posit Aware 1996 Sep-Oct;7(5):12-3. PMID: 11363782

Therapy

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
AIDS-related tumors: integrating antiviral and anticancer therapy.
Tirelli U, Bernardi D, Spina M, Vaccher E
Crit Rev Oncol Hematol 2002 Mar;41(3):299-315. doi: 10.1016/s1040-8428(01)00165-2. PMID: 11880206
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Cancer and HIV infection.
Cottrill CP, Bottomley DM, Phillips RH
Clin Oncol (R Coll Radiol) 1997;9(6):365-80. doi: 10.1016/s0936-6555(97)80129-x. PMID: 9448965

Prognosis

Follow-Up to High-Resolution Anoscopy After Abnormal Anal Cytology in People Living with HIV.
Wells J, Flowers L, Mehta CC, Chandler R, Knott R, McDonnell Holstad M, Watkins Bruner D
AIDS Patient Care STDS 2022 Jul;36(7):263-271. Epub 2022 Jun 21 doi: 10.1089/apc.2022.0057. PMID: 35727648Free PMC Article
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
AIDS-related cancers in the era of highly active antiretroviral therapy.
Biggar RJ
Oncology (Williston Park) 2001 Apr;15(4):439-48; discussion 448-9. PMID: 11346932

Clinical prediction guides

Non-AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era.
Zucchetto A, Virdone S, Taborelli M, Grande E, Camoni L, Pappagallo M, Regine V, Grippo F, Polesel J, Dal Maso L, Suligoi B, Frova L, Serraino D
J Acquir Immune Defic Syndr 2016 Oct 1;73(2):190-6. doi: 10.1097/QAI.0000000000001033. PMID: 27116048
Survival after cancer in Italian persons with AIDS, 1986-2005: a population-based estimation.
Dal Maso L, Suligoi B, Franceschi S, Braga C, Buzzoni C, Polesel J, Zucchetto A, Piselli P, Falcini F, Caldarella A, Zanetti R, Vercelli M, Guzzinati S, Russo A, Tagliabue G, Iachetta F, Ferretti S, Limina RM, Mangone L, Michiara M, Stracci F, Pirino DR, Piffer S, Giacomin A, Vitarelli S, Mazzoleni G, Iannelli A, Contrino ML, Fusco M, Tumino R, Fanetti AC, De Paoli P, Decarli A, Serraino D; Cancer and AIDS Registries Linkage Study
J Acquir Immune Defic Syndr 2014 Aug 1;66(4):428-35. doi: 10.1097/QAI.0000000000000184. PMID: 24798769
The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA
Int J STD AIDS 2007 Feb;18(2):77-80. doi: 10.1258/095646207779949772. PMID: 17331275
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Acquired immunodeficiency syndrome-associated cancers in Sub-Saharan Africa.
Thomas JO
Semin Oncol 2001 Apr;28(2):198-206. doi: 10.1016/s0093-7754(01)90092-2. PMID: 11301383

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