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Adult central nervous system mixed germ cell tumor

MedGen UID:
231038
•Concept ID:
C1332195
•
Neoplastic Process
Synonyms: Adult Central Nervous System Mixed Germ Cell Tumor; adult central nervous system mixed germ cell tumor; adult mixed germ cell tumor of central nervous system; adult mixed germ cell tumour of central nervous system; mixed germ cell tumor of central nervous system of adults; mixed germ cell tumour of central nervous system of adults
 
Monarch Initiative: MONDO:0004406

Definition

A mixed germ cell tumor of central nervous system that occurs in an adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult central nervous system mixed germ cell tumor

Professional guidelines

PubMed

Diffuse Leptomeningeal Glioneuronal Tumors: A Case Series of Five Patients with Parenchymal Forms and an Analysis of the Diagnostic Challenges, Treatment Options and Outcomes.
Demir MK, Yapıcıer O, Kılıc T, Celik S, Oven BB, Ozdamarlar U, Kundak NE, Kanan D, Dincer A, Ertem O, Yakut T, Yılmaz B, Safi S
Curr Med Imaging 2023;19(12):1415-1426. doi: 10.2174/1573405619666230213152949. PMID: 36788686
Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.
Yeo KK, Nagabushan S, Dhall G, Abdelbaki MS
Neoplasia 2023 Feb;36:100860. Epub 2022 Dec 13 doi: 10.1016/j.neo.2022.100860. PMID: 36521378Free PMC Article
Clinical management and outcome of histologically verified adult brainstem gliomas in Switzerland: a retrospective analysis of 21 patients.
Hundsberger T, Tonder M, Hottinger A, Brügge D, Roelcke U, Putora PM, Stupp R, Weller M
J Neurooncol 2014 Jun;118(2):321-328. Epub 2014 Apr 16 doi: 10.1007/s11060-014-1434-1. PMID: 24736829

Recent clinical studies

Therapy

Glioma Tumor Grading Using Radiomics on Conventional MRI: A Comparative Study of WHO 2021 and WHO 2016 Classification of Central Nervous Tumors.
Moodi F, Khodadadi Shoushtari F, Ghadimi DJ, Valizadeh G, Khormali E, Salari HM, Ohadi MAD, Nilipour Y, Jahanbakhshi A, Rad HS
J Magn Reson Imaging 2024 Sep;60(3):923-938. Epub 2023 Nov 29 doi: 10.1002/jmri.29146. PMID: 38031466
Subependymomas - Characteristics of a "Leave me Alone" Lesion.
Kammerer S, Mueller-Eschner M, Lauer A, Luger AL, Quick-Weller J, Franz K, Harter P, Berkefeld J, Wagner M
Rofo 2018 Oct;190(10):955-966. Epub 2018 Jun 18 doi: 10.1055/a-0576-1028. PMID: 29913520
Diffusely infiltrative low-grade gliomas in adults.
Lang FF, Gilbert MR
J Clin Oncol 2006 Mar 10;24(8):1236-45. doi: 10.1200/JCO.2005.05.2399. PMID: 16525178
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, Malmström PO, Collette L, Piérart M, Mirimanoff R, Karim AB; EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council
Lancet 2005 Sep 17-23;366(9490):985-90. doi: 10.1016/S0140-6736(05)67070-5. PMID: 16168780
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Prognosis

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Pediatric Glial Tumors.
Viaene AN, Santi M, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):46-58. Epub 2021 Apr 19 doi: 10.1177/10935266211009101. PMID: 33872106
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, Malmström PO, Collette L, Piérart M, Mirimanoff R, Karim AB; EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council
Lancet 2005 Sep 17-23;366(9490):985-90. doi: 10.1016/S0140-6736(05)67070-5. PMID: 16168780
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Clinical prediction guides

Extraventricular neurocytomas: a systematic review of the literature in the pediatric population.
Lampros MG, Vlachos N, Voulgaris S, Alexiou GA
Childs Nerv Syst 2021 Aug;37(8):2465-2474. Epub 2021 Jun 17 doi: 10.1007/s00381-021-05257-x. PMID: 34137942
Clinicopathologic Features of Diencephalic Neuronal and Glioneuronal Tumors.
Ho CY, Bornhorst M, Almira-Suarez MI, Donev K, Grafe M, Gordish-Dressman H, Rodriguez FJ
J Neuropathol Exp Neurol 2020 Jan 1;79(1):67-73. doi: 10.1093/jnen/nlz115. PMID: 31793986Free PMC Article
Synchronous Tumors of the Cerebellopontine Angle.
Graffeo CS, Perry A, Copeland WR 3rd, Giannini C, Neff BA, Driscoll CL, Link MJ
World Neurosurg 2017 Feb;98:632-643. Epub 2016 Nov 12 doi: 10.1016/j.wneu.2016.11.002. PMID: 27836701
Diffusion characteristics of pediatric pineal tumors.
Choudhri AF, Whitehead MT, Siddiqui A, Klimo P Jr, Boop FA
Neuroradiol J 2015 Apr;28(2):209-16. Epub 2015 May 11 doi: 10.1177/1971400915581741. PMID: 25963154Free PMC Article
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Recent systematic reviews

Cortical mapping in multilinguals undergoing awake brain surgery for brain tumors: Illustrative cases and systematic review.
Pascual JSG, Khu KJO, Starreveld YP
Neuropsychologia 2023 Jan 28;179:108450. Epub 2022 Dec 16 doi: 10.1016/j.neuropsychologia.2022.108450. PMID: 36529263
Extraventricular neurocytomas: a systematic review of the literature in the pediatric population.
Lampros MG, Vlachos N, Voulgaris S, Alexiou GA
Childs Nerv Syst 2021 Aug;37(8):2465-2474. Epub 2021 Jun 17 doi: 10.1007/s00381-021-05257-x. PMID: 34137942
Synchronous Tumors of the Cerebellopontine Angle.
Graffeo CS, Perry A, Copeland WR 3rd, Giannini C, Neff BA, Driscoll CL, Link MJ
World Neurosurg 2017 Feb;98:632-643. Epub 2016 Nov 12 doi: 10.1016/j.wneu.2016.11.002. PMID: 27836701
The role of imaging in the management of adults with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Fouke SJ, Benzinger T, Gibson D, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):457-79. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1908-9. PMID: 26530262
Predictors of seizure freedom after resection of supratentorial low-grade gliomas. A review.
Englot DJ, Berger MS, Barbaro NM, Chang EF
J Neurosurg 2011 Aug;115(2):240-4. Epub 2011 Apr 29 doi: 10.3171/2011.3.JNS1153. PMID: 21529134

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