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Skin Keratotic Basal Cell Carcinoma

MedGen UID:
220985
•Concept ID:
C1304299
•
Neoplastic Process
Synonyms: Basal cell carcinoma - keratotic; Keratotic Basal Cell Carcinoma; Keratotic basal cell carcinoma; Pilar Basal Cell Carcinoma
SNOMED CT: Keratotic basal cell carcinoma (399547009); Basal cell carcinoma - keratotic (402528005)

Definition

A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma. It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands. Dystrophic calcification is frequently present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Keratotic Basal Cell Carcinoma

Professional guidelines

PubMed

Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Topical therapy in the treatment of actinic keratosis and basal cell carcinoma.
Newman MD, Weinberg JM
Cutis 2007 Apr;79(4 Suppl):18-28. PMID: 17508492
Diagnosis and treatment of basal cell and squamous cell carcinomas.
Stulberg DL, Crandell B, Fawcett RS
Am Fam Physician 2004 Oct 15;70(8):1481-8. PMID: 15526735

Recent clinical studies

Etiology

Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer.
Green AC, Way M, Oster M, Plasmeijer EI, Jiyad Z, O'Rourke P, Miura K, Campbell S, Isbel N, Chambers DC, Hopkins P, Ferguson LE, Davis MB, Whiteman DC, Soyer HP, Marquart L
Arch Dermatol Res 2022 Mar;314(2):203-206. Epub 2020 Sep 5 doi: 10.1007/s00403-020-02136-4. PMID: 32889576Free PMC Article
Basal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose region.
Kornevs E, Apse IA, Safronovs TJ, Krastina A, Paparde A, Lauskis G, Salms G
Stomatologija 2020;22(1):9-16. PMID: 32706341
A Clinical Study of Basal Cell Carcinoma.
Kasumagic-Halilovic E, Hasic M, Ovcina-Kurtovic N
Med Arch 2019 Dec;73(6):394-398. doi: 10.5455/medarh.2019.73.394-398. PMID: 32082007Free PMC Article
Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Improving detection of non-melanoma skin cancer Non-melanoma skin cancer.
Natafji N, Tidman MJ
Practitioner 2015 Jul-Aug;259(1784):23-7, 3. PMID: 26514057

Diagnosis

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Expression and Significance of AQP3 in Cutaneous Lesions.
Niu D, Bai Y, Yao Q, Hou W, Zhou L, Huang X, Zhao C
Anal Cell Pathol (Amst) 2021;2021:7866471. Epub 2021 Oct 26 doi: 10.1155/2021/7866471. PMID: 34745849Free PMC Article
A Clinical Study of Basal Cell Carcinoma.
Kasumagic-Halilovic E, Hasic M, Ovcina-Kurtovic N
Med Arch 2019 Dec;73(6):394-398. doi: 10.5455/medarh.2019.73.394-398. PMID: 32082007Free PMC Article
Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Benign lichenoid keratosis.
Goette DK
Arch Dermatol 1980 Jul;116(7):780-2. PMID: 7396541

Therapy

Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Cutaneous adverse effects of targeted therapies: Part II: Inhibitors of intracellular molecular signaling pathways.
Macdonald JB, Macdonald B, Golitz LE, LoRusso P, Sekulic A
J Am Acad Dermatol 2015 Feb;72(2):221-36; quiz 237-8. doi: 10.1016/j.jaad.2014.07.033. PMID: 25592339
Osteopontin expression in normal skin and non-melanoma skin tumors.
Chang PL, Harkins L, Hsieh YH, Hicks P, Sappayatosok K, Yodsanga S, Swasdison S, Chambers AF, Elmets CA, Ho KJ
J Histochem Cytochem 2008 Jan;56(1):57-66. Epub 2007 Oct 15 doi: 10.1369/jhc.7A7325.2007. PMID: 17938278Free PMC Article
Topical therapy in the treatment of actinic keratosis and basal cell carcinoma.
Newman MD, Weinberg JM
Cutis 2007 Apr;79(4 Suppl):18-28. PMID: 17508492
Sunlight, keratotic skin lesions and skin cancer in renal transplant recipients.
Bavinck JN, De Boer A, Vermeer BJ, Hartevelt MM, van der Woude FJ, Claas FH, Wolterbeek R, Vandenbroucke JP
Br J Dermatol 1993 Sep;129(3):242-9. doi: 10.1111/j.1365-2133.1993.tb11841.x. PMID: 8286220

Prognosis

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer.
Green AC, Way M, Oster M, Plasmeijer EI, Jiyad Z, O'Rourke P, Miura K, Campbell S, Isbel N, Chambers DC, Hopkins P, Ferguson LE, Davis MB, Whiteman DC, Soyer HP, Marquart L
Arch Dermatol Res 2022 Mar;314(2):203-206. Epub 2020 Sep 5 doi: 10.1007/s00403-020-02136-4. PMID: 32889576Free PMC Article
Basal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose region.
Kornevs E, Apse IA, Safronovs TJ, Krastina A, Paparde A, Lauskis G, Salms G
Stomatologija 2020;22(1):9-16. PMID: 32706341
Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Sunlight, keratotic skin lesions and skin cancer in renal transplant recipients.
Bavinck JN, De Boer A, Vermeer BJ, Hartevelt MM, van der Woude FJ, Claas FH, Wolterbeek R, Vandenbroucke JP
Br J Dermatol 1993 Sep;129(3):242-9. doi: 10.1111/j.1365-2133.1993.tb11841.x. PMID: 8286220

Clinical prediction guides

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Basal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose region.
Kornevs E, Apse IA, Safronovs TJ, Krastina A, Paparde A, Lauskis G, Salms G
Stomatologija 2020;22(1):9-16. PMID: 32706341
Cutaneous adverse effects of targeted therapies: Part II: Inhibitors of intracellular molecular signaling pathways.
Macdonald JB, Macdonald B, Golitz LE, LoRusso P, Sekulic A
J Am Acad Dermatol 2015 Feb;72(2):221-36; quiz 237-8. doi: 10.1016/j.jaad.2014.07.033. PMID: 25592339
Cornification (keratinization) in Basal cell carcinoma: a histopathological and immunohistochemical study of 16 cases.
Misago N, Satoh T, Narisawa Y
J Dermatol 2004 Aug;31(8):637-50. doi: 10.1111/j.1346-8138.2004.tb00570.x. PMID: 15492437
Pilomatrix carcinoma: a clinicopathologic study of six cases and review of the literature.
Hardisson D, Linares MD, Cuevas-Santos J, Contreras F
Am J Dermatopathol 2001 Oct;23(5):394-401. doi: 10.1097/00000372-200110000-00002. PMID: 11801770

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