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Trench fever

MedGen UID:
21637
•Concept ID:
C0040830
•
Disease or Syndrome
Synonyms: Bartonella quintana Infection; Bartonella quintana Infections; Fever, Trench; Infection, Bartonella quintana; Trench Fever
SNOMED CT: Trench fever (82214002); Quintan fever (82214002); Wolhynian fever (82214002); Fever due to Rochalimaea quintana (82214002); Fever due to Bartonella quintana (82214002); Five day fever (82214002); Febris quintata (82214002)
 
Monarch Initiative: MONDO:0005991
Orphanet: ORPHA64694

Definition

A rare bacterial infectious disease caused by the louse-borne bacterium <i>Bartonella quintana</i> and characterized by a variable clinical picture with acute or insidious onset of a (potentially relapsing) febrile illness, headache, leg pain (most typically the shinbone), endocarditis, and thrombocytopenia. There may also be only non-specific symptoms that mimic other infections. The disease nowadays most commonly affects socially disadvantaged persons in urban areas. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrench fever
Follow this link to review classifications for Trench fever in Orphanet.

Professional guidelines

PubMed

Management and Treatment of Human Lice.
Sangaré AK, Doumbo OK, Raoult D
Biomed Res Int 2016;2016:8962685. Epub 2016 Jul 27 doi: 10.1155/2016/8962685. PMID: 27529073Free PMC Article
Bartonella infection: treatment and drug resistance.
Biswas S, Rolain JM
Future Microbiol 2010 Nov;5(11):1719-31. doi: 10.2217/fmb.10.133. PMID: 21133691
Bartonella quintana characteristics and clinical management.
Foucault C, Brouqui P, Raoult D
Emerg Infect Dis 2006 Feb;12(2):217-23. doi: 10.3201/eid1202.050874. PMID: 16494745Free PMC Article

Recent clinical studies

Etiology

Lice and lice-borne diseases in humans in Africa: A narrative review.
Ouarti B, Mbogning Fonkou DM, Houhamdi L, Mediannikov O, Parola P
Acta Trop 2023 Jan;237:106709. Epub 2022 Oct 2 doi: 10.1016/j.actatropica.2022.106709. PMID: 36198330
Bartonella quintana Infection in People Experiencing Homelessness in the Denver Metropolitan Area.
Shepard Z, Vargas Barahona L, Montalbano G, Rowan SE, Franco-Paredes C, Madinger N
J Infect Dis 2022 Oct 7;226(Suppl 3):S315-S321. doi: 10.1093/infdis/jiac238. PMID: 35749315
Bartonella quintana endocarditis in a child from Northern Manitoba, Canada.
Boodman C, MacDougall W, Hawkes M, Tyrrell G, Fanella S
PLoS Negl Trop Dis 2022 May;16(5):e0010399. Epub 2022 May 26 doi: 10.1371/journal.pntd.0010399. PMID: 35617170Free PMC Article
Ectoparasites: Pediculosis and tungiasis.
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
A Personal View of How Paleomicrobiology Aids Our Understanding of the Role of Lice in Plague Pandemics.
Raoult D
Microbiol Spectr 2016 Aug;4(4) doi: 10.1128/microbiolspec.PoH-0001-2014. PMID: 27726806

Diagnosis

Lice and lice-borne diseases in humans in Africa: A narrative review.
Ouarti B, Mbogning Fonkou DM, Houhamdi L, Mediannikov O, Parola P
Acta Trop 2023 Jan;237:106709. Epub 2022 Oct 2 doi: 10.1016/j.actatropica.2022.106709. PMID: 36198330
Bartonella quintana Infection in People Experiencing Homelessness in the Denver Metropolitan Area.
Shepard Z, Vargas Barahona L, Montalbano G, Rowan SE, Franco-Paredes C, Madinger N
J Infect Dis 2022 Oct 7;226(Suppl 3):S315-S321. doi: 10.1093/infdis/jiac238. PMID: 35749315
Ectoparasites: Pediculosis and tungiasis.
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Bartonella-associated infections.
Spach DH, Koehler JE
Infect Dis Clin North Am 1998 Mar;12(1):137-55. doi: 10.1016/s0891-5520(05)70414-1. PMID: 9494835
Current knowledge of Bartonella species.
Maurin M, Birtles R, Raoult D
Eur J Clin Microbiol Infect Dis 1997 Jul;16(7):487-506. doi: 10.1007/BF01708232. PMID: 9272384

Therapy

Ectoparasites: Pediculosis and tungiasis.
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Bartonella infection: treatment and drug resistance.
Biswas S, Rolain JM
Future Microbiol 2010 Nov;5(11):1719-31. doi: 10.2217/fmb.10.133. PMID: 21133691
Presumed oculoglandular syndrome from Bartonella quintana.
Borboli S, Afshari NA, Watkins L, Foster CS
Ocul Immunol Inflamm 2007 Jan-Feb;15(1):41-3. doi: 10.1080/09273940601077157. PMID: 17365807
Bartonella-associated infections.
Spach DH, Koehler JE
Infect Dis Clin North Am 1998 Mar;12(1):137-55. doi: 10.1016/s0891-5520(05)70414-1. PMID: 9494835
Current knowledge of Bartonella species.
Maurin M, Birtles R, Raoult D
Eur J Clin Microbiol Infect Dis 1997 Jul;16(7):487-506. doi: 10.1007/BF01708232. PMID: 9272384

Prognosis

Bartonella quintana Endocarditis in a Homeless Man with Cat Exposure in San Diego, California.
Promer K, Cowell AN, Reed SL, Castellanos LR, Aronoff-Spencer E
Vector Borne Zoonotic Dis 2020 Jun;20(6):468-470. Epub 2020 Jan 9 doi: 10.1089/vbz.2019.2556. PMID: 31916921Free PMC Article
A Case of Bartonella Quintana Culture-Negative Endocarditis.
Patel S, Richert ME, White R, Lambing T, Saleeb P
Am J Case Rep 2019 Apr 26;20:602-606. doi: 10.12659/AJCR.915215. PMID: 31026253Free PMC Article
An unusual autopsy case of lethal hypothermia exacerbated by body lice-induced severe anemia.
Nara A, Nagai H, Yamaguchi R, Makino Y, Chiba F, Yoshida K, Yajima D, Iwase H
Int J Legal Med 2016 May;130(3):765-9. Epub 2015 Sep 18 doi: 10.1007/s00414-015-1266-3. PMID: 26384507
Presumed oculoglandular syndrome from Bartonella quintana.
Borboli S, Afshari NA, Watkins L, Foster CS
Ocul Immunol Inflamm 2007 Jan-Feb;15(1):41-3. doi: 10.1080/09273940601077157. PMID: 17365807
Bacillary angiomatosis and other Bartonella species infections.
Wong R, Tappero J, Cockerell CJ
Semin Cutan Med Surg 1997 Sep;16(3):188-99. doi: 10.1016/s1085-5629(97)80042-9. PMID: 9300630

Clinical prediction guides

Blood culture-negative endocarditis caused by Bartonella quintana in Iran.
Azimzadeh M, Alikhani MY, Sazmand A, Saberi K, Farahani Z, Kamali M, Haddadzadeh M, Safarpoor G, Nourian A, Mohammadi Y, Beikpour F, Salehi M, Greco G, Chomel B
Sci Rep 2024 Oct 30;14(1):26063. doi: 10.1038/s41598-024-77757-0. PMID: 39478136Free PMC Article
Human dental pulp stem cells: A sanctuary for relapsing Bartonella quintana.
Oumarou Hama H, Hamada A, Aboudharam G, Ghigo É, Drancourt M
Microb Pathog 2021 Apr;153:104797. Epub 2021 Feb 18 doi: 10.1016/j.micpath.2021.104797. PMID: 33609646
Skin diseases associated with Bartonella infection: facts and controversies.
Piérard-Franchimont C, Quatresooz P, Piérard GE
Clin Dermatol 2010 Sep-Oct;28(5):483-8. doi: 10.1016/j.clindermatol.2010.03.003. PMID: 20797506
An immunocompromised murine model of chronic Bartonella infection.
Chiaraviglio L, Duong S, Brown DA, Birtles RJ, Kirby JE
Am J Pathol 2010 Jun;176(6):2753-63. Epub 2010 Apr 15 doi: 10.2353/ajpath.2010.090862. PMID: 20395436Free PMC Article
The Janus face of Bartonella quintana recognition by Toll-like receptors (TLRs): a review.
Matera G, Liberto MC, Joosten LA, Vinci M, Quirino A, Pulicari MC, Kullberg BJ, Van der Meer JW, Netea MG, Focà A
Eur Cytokine Netw 2008 Sep;19(3):113-8. Epub 2008 Sep 8 doi: 10.1684/ecn.2008.0128. PMID: 18775802

Recent systematic reviews

Bartonella quintana detection among arthropods and their hosts: a systematic review and meta-analysis.
Boodman C, Gupta N, van Griensven J, Van Bortel W
Parasit Vectors 2024 Aug 2;17(1):328. doi: 10.1186/s13071-024-06413-3. PMID: 39095833Free PMC Article
Bartonella quintana Endocarditis: A Systematic Review of Individual Cases.
Boodman C, Gupta N, Nelson CA, van Griensven J
Clin Infect Dis 2024 Mar 20;78(3):554-561. doi: 10.1093/cid/ciad706. PMID: 37976173

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