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Sporotrichosis

MedGen UID:
21298
Concept ID:
C0038034
Disease or Syndrome
Synonym: Rose gardener's disease
SNOMED CT: Sporotrichosis (42094007); Infection by Sporothrix schenkii (42094007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005968
Orphanet: ORPHA826

Definition

Sporotrichosis is an infection caused by the dimorphic fungus <i>Sporothrix schenckii</i>, generally occurring by traumatic inoculation of fungus from contaminated soil, plants, and organic matter, that has a highly variable disease spectrum but that usually presents as a subcutaneous mycosis with a single sporotrichotic chancre that may ulcerate and can then progress to lymphocutaneous (most common form; sporotrichotic chancre at inoculation site and a string of similar nodules along the proximal lymphatics), fixed cutaneous (localized asymptomatic, erythematous, papules at the inoculation site), or multifocal or disseminated cutaneous (rare form, with 3 or more lesions involving 2 different anatomical sites) forms. Pulmonary sporotrichosis occurs following inhalation of fungus and manifests as chronic pneumonitis while extracutaneous or systemic sporotrichosis (with osteoarticular, pulmonary, and central nervous system/meningeal disease) has also been reported, usually occurring in the setting of immunosuppression. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSporotrichosis
Follow this link to review classifications for Sporotrichosis in Orphanet.

Professional guidelines

PubMed

Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group
Am J Respir Crit Care Med 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. PMID: 21193785
Restrepo A
J Am Acad Dermatol 1994 Sep;31(3 Pt 2):S91-102. doi: 10.1016/s0190-9622(08)81277-7. PMID: 8077517

Recent clinical studies

Etiology

Uemura EVG, Rossato L
Mycoses 2023 Oct;66(10):845-853. Epub 2023 Jun 28 doi: 10.1111/myc.13627. PMID: 37376902
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Yeoh DK, Butters C, Curtis N
Pediatr Infect Dis J 2019 Jun;38(6S Suppl 1):S52-S59. doi: 10.1097/INF.0000000000002324. PMID: 31205246
Aung AK, Spelman DW, Thompson PJ
Semin Respir Crit Care Med 2015 Oct;36(5):756-66. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562901. PMID: 26398541
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group
Am J Respir Crit Care Med 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. PMID: 21193785

Diagnosis

Schwalb A, Carcamo PM, Seas C
Am J Trop Med Hyg 2022 Jan 24;106(3):758-759. doi: 10.4269/ajtmh.21-1212. PMID: 35073510Free PMC Article
Vásquez-del-Mercado E, Arenas R, Padilla-Desgarenes C
Clin Dermatol 2012 Jul-Aug;30(4):437-43. doi: 10.1016/j.clindermatol.2011.09.017. PMID: 22682194
Barros MB, de Almeida Paes R, Schubach AO
Clin Microbiol Rev 2011 Oct;24(4):633-54. doi: 10.1128/CMR.00007-11. PMID: 21976602Free PMC Article
Ramos-e-Silva M, Vasconcelos C, Carneiro S, Cestari T
Clin Dermatol 2007 Mar-Apr;25(2):181-7. doi: 10.1016/j.clindermatol.2006.05.006. PMID: 17350497
Morris-Jones R
Clin Exp Dermatol 2002 Sep;27(6):427-31. doi: 10.1046/j.1365-2230.2002.01087.x. PMID: 12372075

Therapy

Schwalb A, Carcamo PM, Seas C
Am J Trop Med Hyg 2022 Jan 24;106(3):758-759. doi: 10.4269/ajtmh.21-1212. PMID: 35073510Free PMC Article
Vásquez-del-Mercado E, Arenas R, Padilla-Desgarenes C
Clin Dermatol 2012 Jul-Aug;30(4):437-43. doi: 10.1016/j.clindermatol.2011.09.017. PMID: 22682194
Morris-Jones R
Clin Exp Dermatol 2002 Sep;27(6):427-31. doi: 10.1046/j.1365-2230.2002.01087.x. PMID: 12372075
Piérard GE, Arrese JE, Piérard-Franchimont C
Expert Opin Pharmacother 2000 Jan;1(2):287-304. doi: 10.1517/14656566.1.2.287. PMID: 11249550
Davis BA
Dermatol Clin 1996 Jan;14(1):69-76. doi: 10.1016/s0733-8635(05)70326-0. PMID: 8821159

Prognosis

Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Queiroz-Telles F, Fahal AH, Falci DR, Caceres DH, Chiller T, Pasqualotto AC
Lancet Infect Dis 2017 Nov;17(11):e367-e377. Epub 2017 Jul 31 doi: 10.1016/S1473-3099(17)30306-7. PMID: 28774696
Morris-Jones R
Clin Exp Dermatol 2002 Sep;27(6):427-31. doi: 10.1046/j.1365-2230.2002.01087.x. PMID: 12372075
Davis BA
Dermatol Clin 1996 Jan;14(1):69-76. doi: 10.1016/s0733-8635(05)70326-0. PMID: 8821159

Clinical prediction guides

Sendrasoa FA, Ratovonjanahary VT, Ranaivo IM, Rasamoelina T, Rakotoarisaona MF, Andrianarison M, Ramarozatovo LS, Rabenja FR
PLoS Negl Trop Dis 2023 Jul;17(7):e0011478. Epub 2023 Jul 26 doi: 10.1371/journal.pntd.0011478. PMID: 37494410Free PMC Article
Ikeda MAK, Ferreira KS
Curr Top Microbiol Immunol 2021;432:35-44. doi: 10.1007/978-3-030-83391-6_4. PMID: 34972876
Temelkova I, Tchernev G
Wien Med Wochenschr 2020 May;170(7-8):196-198. Epub 2020 Jan 28 doi: 10.1007/s10354-019-00730-4. PMID: 31993874
Ramos-e-Silva M, Lima CM, Schechtman RC, Trope BM, Carneiro S
Clin Dermatol 2012 Nov-Dec;30(6):616-27. doi: 10.1016/j.clindermatol.2012.01.008. PMID: 23068149
Bayles MA
Chemotherapy 1992;38 Suppl 1:27-34. doi: 10.1159/000239050. PMID: 1319312

Recent systematic reviews

de Oliveira VF, Petrucci JF, Taborda M, Brener PZ, Kremer PGBB, Randi BA, Magri ASGK, Magri MMC, Levin AS, Silva GD
Mycoses 2024 Feb;67(2):e13697. doi: 10.1111/myc.13697. PMID: 38374494
Uemura EVG, Rossato L
Mycoses 2023 Oct;66(10):845-853. Epub 2023 Jun 28 doi: 10.1111/myc.13627. PMID: 37376902
Toriello C, Brunner-Mendoza C, Ruiz-Baca E, Duarte-Escalante E, Pérez-Mejía A, Del Rocío Reyes-Montes M
Braz J Microbiol 2021 Mar;52(1):49-62. Epub 2020 Oct 30 doi: 10.1007/s42770-020-00387-x. PMID: 33125684Free PMC Article
Ramírez Soto MC, Malaga G
Int J Dermatol 2017 Oct;56(10):1037-1045. Epub 2017 Jul 3 doi: 10.1111/ijd.13665. PMID: 28670680
Moreira JA, Freitas DF, Lamas CC
Infection 2015 Jun;43(3):267-76. Epub 2015 Feb 21 doi: 10.1007/s15010-015-0746-1. PMID: 25701221

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